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Source: Atherosclerosis
Condition: Heart Attack
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Total 556 results found since Jan 2013.
Rational Design of a Double-Locked Photoacoustic Probe for Precise In Vivo Imaging of Cathepsin B in Atherosclerotic Plaques
J Am Chem Soc. 2023 Aug 2. doi: 10.1021/jacs.3c04981. Online ahead of print.ABSTRACTAtherosclerotic plaque rupture is a significant cause of acute cardiovascular events such as heart attack and stroke, triggered by the decomposition of fiber caps induced by cysteine cathepsin. However, the accurate measurement of cathepsin B (CTB) activity in plaques is challenging due to the low specificity and insufficient penetration depth of available atherosclerosis-associated cathepsin fluorescent probes, hampering reliable assessment of plaque vulnerability. To address these limitations, we added both lipophilic alkyl chain and hydr...
Source: Atherosclerosis - August 2, 2023 Category: Cardiology Authors: Yuan Ma Jinhui Shang Liuhui Liu Menghuan Li Xinyu Xu Hui Cao Li Xu Wei Sun Guosheng Song Xiao-Bing Zhang Source Type: research
Anti-inflammatory therapies were associated with reduced risk of myocardial infarction in patients with established cardiovascular disease or high cardiovascular risks: A systematic review and meta-analysis of randomized controlled trials
CONCLUSIONS: Anti-inflammatory therapies, especially those targeting the central IL-6 signaling pathway, may serve as promising treating strategies to ameliorate the risk of MI. IL-1 inhibitor and colchicine were associated with decreased risks of heart failure and stroke, respectively. MI risk reduction by anti-inflammatory therapies seemed to be more prominent in older patients with long follow-up duration.PMID:37527612 | DOI:10.1016/j.atherosclerosis.2023.06.972
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: Zonglin Li Chu Lin Xiaoling Cai Suiyuan Hu Fang Lv Wenjia Yang Xingyun Zhu Linong Ji Source Type: research
Profile of Nagasaki Islands Study (NaIS): A Population-Based Prospective Cohort Study on Multi-disease
In conclusion, the NaIS has been undertaken to reveal the influence of aging and risk factors of noncommunicable diseases and disabilities, with an aim to contribute towards better healthcare in the future.PMID:37517991 | DOI:10.2188/jea.JE20230079
Source: Atherosclerosis - July 30, 2023 Category: Cardiology Authors: Jun Miyata Hirotomo Yamanashi Shin-Ya Kawashiri Sakiko Soutome Kazuhiko Arima Mami Tamai Fumiaki Nonaka Yukiko Honda Masayasu Kitamura Koji Yoshida Yuji Shimizu Naomi Hayashida Shigeru Kawakami Noboru Takamura Takashi Sawase Atsutoshi Yoshimura Yasuhiro N Source Type: research
Peripheral artery disease: Update on etiology, pathophysiology, diagnosis and treatment
Med Clin (Barc). 2023 Jul 28:S0025-7753(23)00361-5. doi: 10.1016/j.medcli.2023.06.005. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) is a condition related to atherosclerosis affecting >200 million people worldwide, and it increases cardiovascular morbidity (mainly from myocardial infarction and stroke) and mortality. Indeed, PAD patients are classified as patients at very high cardiovascular risk. The most common manifestation of PAD is intermittent claudication, which is associated with reduced mobility and leg pain. Nevertheless, asymptomatic PAD is the most frequent form of PAD worldwide; therefore, ...
Source: Atherosclerosis - July 30, 2023 Category: Cardiology Authors: Dar ío Mandaglio-Collados Francisco Mar ín Jos é Miguel Rivera-Caravaca Source Type: research
Do Non-Functional Adrenal Adenomas Affect Metabolic Profile and Carotid Intima-Media Thickness? A Single Centre Study from Poland
Conclusions: Patients diagnosed with NFAIs, despite normal cortisol inhibition in the 1 mg dexamethasone test, still presented a number of metabolic abnormalities. The assessment of IMT may proove valuable in indicate the presence of early vascular remodelling in asymptomatic patients. The underlying mechanisms of these findings are still unknown, hence further studies are required.PMID:37510727 | PMC:PMC10380859 | DOI:10.3390/jcm12144612
Source: Atherosclerosis - July 29, 2023 Category: Cardiology Authors: Magdalena Szychli ńska Magdalena Rzeczkowska Katarzyna Gontarz-Nowak Wojciech Matuszewski El żbieta Bandurska-Stankiewicz Source Type: research
Sestrin2 as a Potential Target in Hypertension
Diagnostics (Basel). 2023 Jul 14;13(14):2374. doi: 10.3390/diagnostics13142374.ABSTRACTHypertension is a highly complex, intricate condition affecting millions of individuals across the globe. Nearly half of adults in the United States are diagnosed with hypertension, with incident rates projected to rise over the next decade. Hypertension is a precursor to many cardiovascular diseases including atherosclerosis, stroke, myocardial infarction, heart failure, and peripheral artery disease. This review describes the major processes contributing to the development of hypertension and how Sestrin2 (Sesn2), an antioxidative prot...
Source: Atherosclerosis - July 29, 2023 Category: Cardiology Authors: Steven Didik Hao Wang Adewale Segun James Lily Slotabec Ji Li Source Type: research
Use of neuromuscular blockade for neck dissection and association with iatrogenic nerve injury
CONCLUSIONS: In this study, use of neuromuscular blockade intraoperatively during neck dissection was not associated with increased rates of iatrogenic cranial nerve injury. While this investigation provides early support for safe use of neuromuscular blockade during neck dissection, future investigation with greater power remains necessary.PMID:37507689 | DOI:10.1186/s12871-023-02217-7
Source: Atherosclerosis - July 28, 2023 Category: Cardiology Authors: Joshua D Smith Graciela Mentz Aleda M Leis Yuan Yuan Chaz L Stucken Steven B Chinn Keith A Casper Kelly M Malloy Andrew G Shuman Scott A McLean Andrew J Rosko Mark E P Prince Kevin K Tremper Matthew E Spector Samuel A Schechtman Source Type: research
Assessing statins use in a real-world primary care digital strategy: a cross-sectional analysis of a population-wide digital health approach
Lancet Reg Health Am. 2023 Jun 22;23:100534. doi: 10.1016/j.lana.2023.100534. eCollection 2023 Jul.ABSTRACTBACKGROUND: The digitization of the primary care system provides an opportunity to evaluate the current use of statins in secondary prevention populations (myocardial infarction or stroke).METHODS: We conducted a cross-sectional study (ClinicalTrials.gov, NCT05285085), analysing anonymised data routinely collected by community health workers (CHW) in Brazil between May 2016 and September 2021 to assess the proportion of self-reported statins use and associated factors.FINDINGS: From the 2,133,900 individuals on the da...
Source: Atherosclerosis - July 27, 2023 Category: Cardiology Authors: M Julia Machline-Carrion Alysson Nathan Girotto Josu é Nieri Pedro Marton Pereira Frederico Monfardini Francisco Forestiero Priscila Raupp Fabiana Roveda Karla Santo Ot ávio Berwanger Raul D Santos Source Type: research
Active and allosteric site binding MM-QM studies of Methylidene tetracyclo derivative in PCSK9 protein intended to make a safe antilipidemic agent
This study aims to evaluate the interaction between Methylidene tetracyclo derivative and PCSK9 protein through conceptual studies and compare the same with the interaction of the standard atorvastatin. Also, a comparative study was performed to analyze the interaction of molecules inside the active and allosteric sites of PCSK9. The RCSB downloaded pdb file 7S5H and the above said ligands were optimized to the level of local minima energy and configured inside the active and allosteric sites. The stability of non-bonded interactions of the complexes were analyzed using Desmond MD simulation studies. The results of docking...
Source: Atherosclerosis - July 26, 2023 Category: Cardiology Authors: N Irfan Prakash Vaithyanathan Harishchander Anandaram S Mohammed Zaidh S Priya Varshini A Puratchikody Source Type: research
Position of the Polish Cardiac Society on therapeutic targets for LDL cholesterol concentrations in secondary prevention of myocardial infarctions
Kardiol Pol. 2023 Jul 25. doi: 10.33963/KP.a2023.0162. Online ahead of print.ABSTRACTCardiovascular diseases account for 43% of deaths in Poland. The COVID-19 pandemic increased the number of cardiovascular deaths by as much as 16.7%. Lipid metabolism disorders are observed in about 20 million Poles. Lipid disorders are usually asymptomatic, they cause a significant increase in the risk of cardiovascular diseases. Up to 20% of patients who experience an acute coronary syndrome (ACS) may experience a recurrence of a cardiovascular event within a year, and up to 40% of these patients may be re-hospitalized. Within 5 years af...
Source: Atherosclerosis - July 25, 2023 Category: Cardiology Authors: Przemys ław Mitkowski Adam Witkowski Janina St ępińska Maciej Banach Piotr Jankowski Mariusz G ąsior Krystian Wita Stanis ław Bartuś Pawe ł Burchardt Micha ł M Farkowski Marek Gierlotka Robert Gil Przemys ław Leszek Maciej Sterli ński Piotr Szym Source Type: research
AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD
CONCLUSIONS: Through 10-year follow-up, AI-QCT plaque staging showed important prognostic value for MACE and showed additional discriminatory value over clinical risk factors, CACS, and manual guideline-recommended CCTA assessment.PMID:37480907 | DOI:10.1016/j.jcmg.2023.05.020
Source: Atherosclerosis - July 22, 2023 Category: Cardiology Authors: Nick S Nurmohamed Michiel J Bom Ruurt A Jukema Robin J de Groot Roel S Driessen Pepijn A van Diemen Ruben W de Winter Emilie L Gaillard Ralf W Sprengers Erik S G Stroes James K Min James P Earls Rhanderson Cardoso Ron Blankstein Ibrahim Danad Andrew D Cho Source Type: research
The Role of Platelets in Non-Alcoholic Fatty Liver Disease: From Pathophysiology to Therapeutics
Prostaglandins Other Lipid Mediat. 2023 Jul 19:106766. doi: 10.1016/j.prostaglandins.2023.106766. Online ahead of print.ABSTRACTPlatelets are one of the key mediators in thrombosis as well as in the progression of many diseases. An increase in platelet activation and a decrease in platelet count is associated with a plethora of liver diseases. In non-alcoholic fatty liver disease (NAFLD), platelets are highly activated and participate in the disease progression by enhancing the pro-thrombotic and pro-inflammatory state. Some altered platelet parameters such as mean platelet volume, plateletcrits, and platelet distribution ...
Source: Atherosclerosis - July 21, 2023 Category: Cardiology Authors: Malladi Navya Md Jahangir Alam Subir K Maulik Sanjay K Banerjee Source Type: research
