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Source: Atherosclerosis
Condition: Heart Attack
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Total 556 results found since Jan 2013.
Association between complete revascularization of the coronary artery and clinical outcomes in peripheral artery disease: a sub-analysis of the I-PAD Nagano registry
This study was based on a prospective, multicenter, observational registry in Japan. We enrolled 366 patients with PAD undergoing endovascular treatment. The primary endpoint was MACE, defined as a composite of all-cause death, non-fatal myocardial infarction, and non-fatal stroke. After excluding ineligible patients, 96 and 68 patients received complete revascularization of the coronary artery (CR group) and incomplete revascularization of the coronary artery (ICR group), respectively. Freedom from MACE in the CR group was significantly higher than in the ICR group at 5 years (66.7% vs 46.0%, p < 0.01). Multivariate an...
Source: Atherosclerosis - April 13, 2023 Category: Cardiology Authors: Tamon Kato Yasushi Ueki Masatoshi Minamisawa Takashi Miura Yushi Oyama Naoto Hashizume Daisuke Yokota Minami Taki Keisuke Senda Yoshiteru Okina Tadamasa Wakabayashi Koki Fujimori Kenichi Karube Takahiro Sakai Hidetomo Nomi Hisanori Yui Yusuke Kanzaki Keis Source Type: research
Inflammation Beats Cholesterol: A Comment on the Unequivocal Driver of Cardiovascular Disease Risk
J Clin Med. 2023 Mar 27;12(7):2519. doi: 10.3390/jcm12072519.ABSTRACTDespite advancements in the current standard of care, cardiovascular diseases continue to hold the top spot as the leading cause of mortality worldwide. The development of atherosclerosis is the most common culprit behind ailments such as myocardial infarction, stroke, and peripheral vascular disease. Consequently, it imposes a significant burden on life expectancy, quality of life, morbidity, and societal costs. Both increased cholesterol levels and the activation of the inflammatory cascade are known as cardiovascular risk facts. Their relative weight i...
Source: Atherosclerosis - April 13, 2023 Category: Cardiology Authors: Mauro Vaccarezza Francesco Maria Galassi Source Type: research
A review on the role of SNHG8 in human disorders
Pathol Res Pract. 2023 Apr 7;245:154458. doi: 10.1016/j.prp.2023.154458. Online ahead of print.ABSTRACTSmall nucleolar RNA host gene 8 (SNHG8) is a long non-coding RNA that has physiological roles in epithelial and muscle satellite cells. This lncRNA has been reported to be over-expressed in a variety of cancer cell lines. Its silencing has attenuated tumor growth in animal models of cancers. SNHG8 can be served as a molecular sponge for some miRNAs to regulate their target genes. miR-634/ZBTB20, miR-335-5p/PYGO2, miR588/ATG7, miR-152/c-MET, miR-1270/BACH1, miR-491/PDGFRA, miR-512-5p/TRIM28, miR-149-5p/PPM1F, miR-542-3p/CC...
Source: Atherosclerosis - April 12, 2023 Category: Cardiology Authors: Soudeh Ghafouri-Fard Atefeh Harsij Bashdar Mahmud Hussen Mohammad Taheri Seyed Abdulmajid Ayatollahi Source Type: research
The Potential Cardiometabolic Effects of Long-Chain Omega-3 Polyunsaturated Fatty Acids: Recent Updates and Controversies
Adv Nutr. 2023 Apr 7:S2161-8313(23)00283-1. doi: 10.1016/j.advnut.2023.03.014. Online ahead of print.ABSTRACTVarious health-related effects of long-chain (LC) omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been suggested. LC omega-3 PUFAs reduce triglyceride levels and have anti-inflammatory, immunomodulatory, antiplatelet, and vascular protective effects. Controversially, they might help in restoring glucose homeostasis via the gut microbiota. However, previous studies have not shown the clear benefits of LC omega-3 PUFAs for cardiovascular diseases. REDUCE-IT...
Source: Atherosclerosis - April 9, 2023 Category: Cardiology Authors: Jae Hyun Bae Hyunjung Lim Soo Lim Source Type: research
Air Pollution and Arrhythmias
Can J Cardiol. 2023 Apr 4:S0828-282X(23)00293-3. doi: 10.1016/j.cjca.2023.03.023. Online ahead of print.ABSTRACTAir pollution is commonly defined as the contamination of the air we breathe by any chemical, physical or biological agent that is potentially threatening to human and ecosystem health. The common pollutants known to be disease-causing are particulate matter, ground-level ozone, sulphur dioxide, nitrogen dioxide and carbon monoxide. Although the association between increasing concentrations of these pollutants and cardiovascular disease is now accepted, the association of air pollution and arrhythmias is less wel...
Source: Atherosclerosis - April 6, 2023 Category: Cardiology Authors: Matthew Bennett Isabelle Nault Michael Koehle Stephen Wilton Source Type: research
The predictive value of interarm systolic blood pressure differences in patients with vascular disease: Sub-analysis of the COMPASS trial
CONCLUSIONS: Unlike primary prevention populations, measuring IAD for risk stratification purposes does not appear to be useful in patients with established vascular disease.PMID:37023507 | DOI:10.1016/j.atherosclerosis.2023.03.008
Source: Atherosclerosis - April 6, 2023 Category: Cardiology Authors: Mohammad Qadura Muzammil H Syed Sonia Anand Jackie Bosch Stuart Connolly Victor Aboyans Eva Muehlhofer Salim Yusuf John Eikelboom Source Type: research
Comparison of Prasugrel and Clopidogrel in Thrombotic Stroke Patients with Risk Factors for Ischemic Stroke Recurrence: An Integrated Analysis of PRASTRO-I, PRASTRO-II, and PRASTRO-III
CONCLUSIONS: This integrated analysis supports the findings of PRASTRO-III. Prasugrel is a promising treatment that results in a numerical reduction in the composite incidence of ischemic stroke, MI, and death from other vascular causes in patients with ischemic stroke who are at a high risk of stroke recurrence. No major safety issues were observed for prasugrel.PMID:37011599 | DOI:10.1159/000529149
Source: Atherosclerosis - April 3, 2023 Category: Cardiology Authors: Takanari Kitazono Masahiro Kamouchi Yuji Matsumaru Toshiaki Shirai Atsushi Takita Takeshi Kuroda Kazumi Kimura Source Type: research
Prediction of Coronary Artery Disease Severity by Using CHA2DS2-VASC-HSF Score in Patients with ST-Elevation Myocardial Infarction
In this study mean age of study population was 51.8±9.8, male patients were predominant (79.0%). Among the studied patients, highest percentage had history of smoking followed by hypertension, diabetes mellitus and family history of CAD in Group I patients. It was found that DM and family history of CAD and history of stroke/TIA were significantly higher in Group I than Group II. An increasing trend of SYNTAX score was observed according to the CHA₂DS₂-VASc-HSF score. SYNTAX score was significantly higher in CHA2DS2-VASc-HSF score ≥4 than CHA₂DS₂-VASc-HSF score <4 (26.3±6.3 vs. 12.1±7.7, p<0.001). Patien...
Source: Atherosclerosis - April 1, 2023 Category: Cardiology Authors: M A Rahim M J Uddin J Jahan T A Chowdhury A Momen M M Islam M A Rahman P Bala A Mamun F Chowdhury A R Majumder Source Type: research
Association of non-HDL-C-to-HDL-C ratio with coronary lesions and its prognostic performance in first-onset NSTEMI
Conclusion: NON-HDL-C:HDL-C is associated with coronary lesions and prognosis in non-ST-segment elevation acute myocardial infarction.PMID:36994674 | DOI:10.2217/bmm-2022-0548
Source: Atherosclerosis - March 30, 2023 Category: Cardiology Authors: Qi Mao Jianhua Zhao Xiaohui Zhao Source Type: research
Association of Major Adverse Cardiac Events and Beta-Blockers in Patients with and without Atherosclerotic Cardiovascular Disease: Long-Term Follow-Up Results of the T-SPARCLE and T-PPARCLE Registry in Taiwan
In conclusion, in ASCVD patients, reduced MACE was associated with beta-blocker usage, and the effect was maintained during a six-year follow-up. Prescribing beta-blockers as secondary prevention is reasonable in the Taiwanese population.PMID:36983164 | DOI:10.3390/jcm12062162
Source: Atherosclerosis - March 29, 2023 Category: Cardiology Authors: Patrick Yan-Tyng Liu Fang-Ju Lin Chih-Fan Yeh Yu-Chung Hsiao Chin-Feng Hsuan Wei-Tien Chang Hsien-Li Kao Jiann-Shing Jeng Yen-Wen Wu I-Chang Hsieh Ching-Chang Fang Kuo-Yang Wang Kuan-Cheng Chang Tsung-Hsien Lin Wayne Huey-Herng Sheu Yi-Heng Li Wei-Hsian Y Source Type: research
Podoplanin: A potential therapeutic target for thrombotic diseases
Front Neurol. 2023 Mar 9;14:1118843. doi: 10.3389/fneur.2023.1118843. eCollection 2023.ABSTRACTAs a specific lymphatic marker and a key ligand of C-type lectin-like receptor 2 (CLEC-2), podoplanin (Pdpn) is involved in various physiological and pathological processes such as growth and development, respiration, blood coagulation, lymphangiogenesis, angiogenesis, and inflammation. Thrombotic diseases constitute a major cause of disability and mortality in adults, in which thrombosis and inflammation play a crucial role. Recently, increasing evidence demonstrates the distribution and function of this glycoprotein in thrombot...
Source: Atherosclerosis - March 27, 2023 Category: Cardiology Authors: Yaqian Huang Manli Lu Yi Wang Chunyuan Zhang Yongjun Cao Xia Zhang Source Type: research
Role of sirtuins in attenuating plaque vulnerability in atherosclerosis
Mol Cell Biochem. 2023 Mar 23. doi: 10.1007/s11010-023-04714-2. Online ahead of print.ABSTRACTAtherosclerosis is characterized by the development of intimal plaque, thrombosis, and stenosis of the vessel lumen causing decreased blood flow and hypoxia precipitating angina. Chronic inflammation in the stable plaque renders it unstable and rupture of unstable plaques results in the formation of emboli leading to hypoxia/ischemia to the organs by occluding the terminal branches and precipitate myocardial infarction and stroke. Such delibitating events could be controlled by the strategies that prevent plaque development or pla...
Source: Atherosclerosis - March 23, 2023 Category: Cardiology Authors: Prathosh Velpuri Vikrant Rai Devendra K Agrawal Source Type: research
Carotid Endarterectomy Versus Stenting for the Treatment of Patients With Carotid Artery Stenosis: An Updated Systematic Review and Meta-Analysis
Cureus. 2023 Feb 16;15(2):e35070. doi: 10.7759/cureus.35070. eCollection 2023 Feb.ABSTRACTCarotid endarterectomy (CEA) is a surgical procedure that treats the narrowed carotid arteries, which may be narrowed by atherosclerosis. Stenting is the insertion of a wire mesh scaffold into the narrowed portion of the carotid artery to keep it open by preventing blood from clotting. Using the study done over 10 years back as a point of reference, this study will seek an update on an assessment comparing CEA and stenting in studies carried out between 2015 and to date. The PICOS (population, intervention, control, outcome, and study...
Source: Atherosclerosis - March 21, 2023 Category: Cardiology Authors: Advait M Vasavada Priyansha Singh Arshia Firdaus Dakshin Meenashi Sundaram Malvik Patel Ganeev Singh Logesh Palanisamy Sana Afreen Ansari Sumaina Thummala Harsh Pandya Source Type: research
