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CT-Negative Subarachnoid Hemorrhage in the First Six Hours
There are no reported cases of negative CT head in the first six hours after a thunderclap headache in a patient found to have an aneurysmal subarachnoid hemorrhage (SAH).
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2020 Category: Neurology Authors: Tia Chakraborty, Ali Daneshmand, Giuseppe Lanzino, Sara Hocker Tags: Case Report Source Type: research

Cerebral Venous Sinus Thromboses in Patients with SARS-CoV-2 Infection: Three Cases and a Review of the Literature
: Early studies suggest that acute cerebrovascular events may be common in patients with coronavirus disease 2019 (COVID-19) and may be associated with a high mortality rate. Most cerebrovascular events described have been ischemic strokes, but both intracerebral hemorrhage and rarely cerebral venous sinus thrombosis (CVST) have also been reported. The diagnosis of CVST can be elusive, with wide-ranging and nonspecific presenting symptoms that can include headache or altered sensorium alone.
Source: Journal of Stroke and Cerebrovascular Diseases - October 19, 2020 Category: Neurology Authors: Felix Nwajei, Pria Anand, Mohamad Abdalkader, Vanesa C. Andreu Arasa, Hugo J. Aparicio, Siavash Behbahani, Gioacchino Curiale, Ali Daneshmand, Hormuzdiyar Dasenbrock, Thomas Mayo, Asim Mian, Thanh Nguyen, Charlene Ong, J. Rafael Romero, Osamu Sakai, Court Source Type: research

Hydrocephalous as a Complication of Perimesencephalic Nonaneurysmal Subarachnoid Hemorrhage
JLSM, male, 71 years old, admitted into a private hospital in the city of Joinville, Brazil, complaining of persistent and severe headache. The patient reported onset of the condition three days before, after sexual activity, associated with nausea, vomiting and dizziness. He has a medical history of epilepsy, under regular use of Phenobarbital. The physical examination evidenced slight nuchal rigidity. Cranial computed tomography (CT) showed subarachnoid hemorrhage (SAH) in cisterns around the brainstem (Fig.
Source: Journal of Stroke and Cerebrovascular Diseases - October 20, 2020 Category: Neurology Authors: Guilherme Zini Reis, Fernanda Subtil de Moraes Machado, Wladimir Kummer de Paula, Fl ávio Diniz Ribas, Felipe Ibiapina dos Reis Tags: Case Report Source Type: research

COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin
A 31-year-old sexually active, non-smoker female with a past medical history of spina-bifida and idiopathic thoracolumbar scoliosis status post hardware spinal fusion surgery five years ago presented with a one-day history of severe holocranial headaches associated with nausea and visual changes. A thorough neurological examination was intact. She complained of mild cough as well. She had a positive nasopharyngeal swab for SARS-CoV-2 on RT-PCR assay. A comprehensive drug screen including amphetamines, cocaine, nicotine, alcohol, and ecstasy as well as a pregnancy test were negative; coagulation profile was within normal limits.
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2021 Category: Neurology Authors: Tarab Mansoor, Ali A. Alsarah, Hossein Mousavi, Javed Elyias, Tarun Girotra, Omar Hussein Tags: Case Report Source Type: research

Focal cerebral arteriopathy in a young adult following SARS-CoV2 reinfection
Ten days after SARS-Cov2 reinfection with mild gastrointestinal symptoms and headache that occurred 2 months after an initial infection, a previously healthy 37-year-old woman developed fluctuating facial and upper limb paresthesia and weakness. Diffusion-weighted magnetic resonance imaging revealed ischemic lesions in the right parietal region of different stages within the same vascular territory. A cerebral angiography demonstrated an isolated focal arteriopathy with no other arterial involvement.
Source: Journal of Stroke and Cerebrovascular Diseases - June 12, 2021 Category: Neurology Authors: Carla Zanferrari, Simona Fanucchi, Maria Teresa Sollazzo, Michela Ranieri, Daniel Volterra, Luca Valvassori Source Type: research

Recurrent Transient Neurological Deficit Due to Intracerebral Steal Phenomenon in Association with a Developmental Venous Anomaly
We report a symptomatic developmental venous anomaly (DVA) not causing parenchymal abnormality to provide a pathophysiologic clue in patients with recurrent transient neurologic deficit. A 32-year-old male presented with recurrent transient motor aphasia and headache in the left fronto-temporal region for three years. The symptoms usually lasted for one hour. Brain computed tomography (CT) angiography and magnetic resonance imaging using gradient recalled echo showed a prominent penetrating vein at the left frontal periventricular region.
Source: Journal of Stroke and Cerebrovascular Diseases - August 24, 2021 Category: Neurology Authors: Jean Hee Kim, Hyeyoung Jung, Woojun Kim, Jae Young An Tags: Case Report Source Type: research

Fulminant reversible cerebral vasoconstriction syndrome in breakthrough COVID 19 infection
We report a case of fulminant reversible cerebrovascular constriction syndrome (RCVS) in a patient with breakthrough COVID 19 infection who was fully vaccinated. A 64 year old lady, fully vaccinated 2 months back, presented with headache, drowsiness, partial seizures, visual impairment and quadriplegia. Her nasopharyngeal swab was tested positive for SARS COV2 on real time PCR assay.
Source: Journal of Stroke and Cerebrovascular Diseases - November 25, 2021 Category: Neurology Authors: Somdattaa Ray, Vikram V Kamath, Arjun Raju P, Rajesh K.N, Shalini N Source Type: research

PRES and RCVS: Two Distinct Entities or a Spectrum of the Same Disease?
Posterior reversible encephalopathy syndrome (PRES) is a disorder characterized by vasogenic edema predominantly in the parieto-occipital regions associated with acute onset of neurological symptoms including encephalopathy, seizures, headache, and visual disturbances. It has been classically associated with uncontrolled hypertension, renal failure, exposure to cytotoxic agents, or pre-eclampsia.1,2 Despite its name, PRES it is not universally posterior nor fully reversible. Up to 10-20% of patients can have persistent neurological sequelae,1 therefore prompt recognition and elimination of triggering factors is of paramount importance.
Source: Journal of Stroke and Cerebrovascular Diseases - April 5, 2022 Category: Neurology Authors: Valerie Jeanneret, Dinesh V. Jillella, Srikant Rangaraju, Olivia Groover, Ryan Peterson, Sitara Koneru, Fadi Nahab, Carlos S. Kase Tags: Short Communication Source Type: research

R558C NOTCH3 Mutation in a CADASIL Patient with Intracerebral Hemorrhage: A Case Report with Literature Review
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic cerebral small-vessel disease, which is characterized by migraine, recurrent ischemic strokes, psychiatric disorder, progressive cognitive decline, and occasionally intracerebral hemorrhage (ICH). ICH events have been reported in a high proportion of East Asian CADASIL patients with R544C mutation in exon 11 of NOTCH3; however, whether any other specific NOTCH3 mutation determines the ICH phenotype has yet to be explored.
Source: Journal of Stroke and Cerebrovascular Diseases - May 3, 2022 Category: Neurology Authors: Liuting Hu, Gang Liu, Yuhua Fan Tags: Case Report Source Type: research

“Recycling” A Failed Superficial Temporal Artery Indirect Bypass into a Double Barrel Direct Bypass in Moyamoya Disease
Moyamoya disease (MMD) is an idiopathic cerebrovascular disorder characterized by progressive stenosis and occlusion of the terminal branches of the internal carotid arteries1. Clinically, MMD is defined by recurrent transient ischemic attacks, strokes, headaches, and seizures. The clinical course of MMD is inconsistent with some patients experiencing sporadic vascular events while others exhibit fulminant disease and rapidly decline1,2. Surgical revascularization by indirect or direct bypass is the mainstay of treatment for moyamoya vasculopathy, although the superiority of direct vs.
Source: Journal of Stroke and Cerebrovascular Diseases - June 1, 2022 Category: Neurology Authors: Alexander G. Yearley, Joshua D. Bernstock, Ari D. Kappel, Jason A. Chen, Erickson Torio, Saksham Gupta, Pui Man Rosalind Lai, Nirav J. Patel Tags: Case Report Source Type: research

Infratentorial developmental venous anomaly concurrent with a cavernoma and dural arteriovenous fistula
A 32-year-old woman underwent a head computed tomography scan after a traffic accident. A calcification in the left cerebellar hemisphere was disclosed. She did not complain of any symptoms, but neurological examination revealed cerebellar ataxia. She did not have any preceding episodes since birth, such as acute-onset headache. Magnetic resonance imaging showed past hemorrhage of the calcification lesion suggestive of a cerebellar cavernoma. A dilated vascular structure was also observed (Fig.  1A, B).
Source: Journal of Stroke and Cerebrovascular Diseases - July 14, 2022 Category: Neurology Authors: Hirokuni Hashikata, Yoshinori Maki, Ryota Ishibashi, Masanori Goto, Hiroki Toda Tags: Case Report Source Type: research

Diagnostic accuracy of MR vessel wall imaging at 2 weeks to predict morphological healing of vertebral artery dissection
Patients with non-hemorrhagic intracranial vertebral artery dissection (VAD) exhibit various symptoms including severe occipital headache alone or focal neurological deficits caused by vertebrobasilar artery ischemia.1 The majority of non-hemorrhagic VAD have a benign clinical course and spontaneously resolve.2, 3 The time course of changes in the imaging characteristics of VAD remains unclear and a follow-up management strategy has not yet been established.4 Since cerebrovascular dissections occur within the cerebrovascular wall, it is important to evaluate the vascular wall to determine whether the dissection has healed spontaneously.
Source: Journal of Stroke and Cerebrovascular Diseases - August 26, 2022 Category: Neurology Authors: Yukishige Hashimoto, Toshinori Matsushige, Reo Kawano, Michitsura Yoshiyama, Takeshi Hara, Shohei Kobayashi, Chiaki Ono, Shigeyuki, Sakamoto, Nobutaka Horie Source Type: research

Vaccine associated benign headache and cutaneous hemorrhage after ChAdOx1 nCoV-19 vaccine: A cohort study
Fatal complications have occurred after vaccination with ChAdOx1 nCoV-19, a vaccine against Covid-19. Vaccine-induced immune thrombotic thrombocytopenia (VITT) with severe outcome is characterized by venous thrombosis, predominantly in cerebral veins, thrombocytopenia and anti-PF4/polyanion antibodies. Prolonged headaches and cutaneous hemorrhages, frequently observed after the ChAdOx1 nCoV-19 vaccine, have therefore caused anxiety among vaccinees. We investigated whether these symptoms represent a mild form of VITT, with a potential for aggravation, e.g.
Source: Journal of Stroke and Cerebrovascular Diseases - November 17, 2022 Category: Neurology Authors: Nina Haagenrud Schultz, Arne Vasli Lund S øraas, Ingvild Hausberg Sørvoll, Çigdem Akalin Akkök, Annette Vetlesen, Jagjit Singh Bhamra, Maria Therese Ahlen, Pål Andre Holme, Anne-Hege Aamodt, Karolina Skagen, Thor Håkon Skattør, Mona Skjelland, Mark Source Type: research

Response to Letter to the Editor
We thank the authors for their interest in our article and the thoughtful comments. As they correctly point out, the association between the first vaccination with ChAdOx1 nCov -19 vaccine and the described symptoms in our article does not prove any causality. However, cutaneous hemorrhages and headaches were frequently reported side effects after vaccination with ChAdOx1 nCov-19 in the Norwegian corona study cohort in young and previously healthy subjects. In lack of previous experience, there was a fear that these symptoms may have represented a mild form of VITT.
Source: Journal of Stroke and Cerebrovascular Diseases - January 20, 2023 Category: Neurology Tags: Letter to the Editor Source Type: research

Comment on vaccine associated benign headache and cutaneous hemorrhage after ChAdOx1 nCoV-19 vaccine
Dear Editor, we would like to share ideas on the publication “Vaccine associated benign headache and cutaneous hemorrhage after ChAdOx1 nCoV-19 vaccine: A cohort study1.” If these symptoms are a minor form of VITT, with a possibility for worsening, such as in the case of a second vaccination dose, or a new entity of vaccine consequences, Schultz et al. ex plored this1. The combination of headaches and subcutaneous hemorrhage, according to Schultz et al., did not indicate VITT, and no other distinct coagulation problem or cerebral pathology was discovered.
Source: Journal of Stroke and Cerebrovascular Diseases - January 23, 2023 Category: Neurology Authors: Rujittika Mungmunpuntipantip, Viroj Wiwanitkit Tags: Letter to the Editor Source Type: research

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