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Human Urinary Kallidinogenase Reduces Lipopolysaccharide-Induced Neuroinflammation and Oxidative Stress in BV-2 Cells.
Abstract Migraine is one of the most common neurological disorders which poses significant socioeconomic burden worldwide. Neuroinflammation and oxidative stress both play important roles in the pathogenesis of migraine. Human urinary kallidinogenase (UK) is a tissue kallikrein derived from human urine. Increasing evidence suggests that UK may protect against ischemic stroke, but UK's treatment potential against migraine remains to be explored. Immortal BV-2 murine microglial cells were treated with UK (125 nM, 250 nM, and 500 nM) and then given lipopolysaccharides (LPS, 1000 ng/mL). Cell viability of BV-2...
Source: Pain Research and Management - August 21, 2019 Category: Anesthesiology Authors: Zhao Z, Xu Z, Liu T, Huang S, Huang H, Huang X Tags: Pain Res Manag Source Type: research

Cognitive Decline in Chronic Migraine with Nonsteroid Anti-inflammation Drug Overuse: A Cross-Sectional Study.
Conclusion: The risk of cognitive decline increased in chronic migraine patients. Nonsteroid anti-inflammatory drugs overuse had no influence on cognitive performances among chronic migraine sufferers. PMID: 31198478 [PubMed - in process]
Source: Pain Research and Management - June 15, 2019 Category: Anesthesiology Authors: Cai X, Xu X, Zhang A, Lin J, Wang X, He W, Fang Y Tags: Pain Res Manag Source Type: research