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Question 1: Role of methotrexate in severe atopic eczema in children
Scenario EW is a 10-year-old female with severe atopic eczema. She has had frequent flare-ups and multiple secondary infections since 6 months of age. Previous therapy has included prednisolone, aciclovir, flucloxacillin, topical fucibet, emollients and steroids. She currently requires high-dose steroids and symptoms recur when tapering the dose. EW's eczema has a severe impact on her quality of life: she has low self-esteem, struggles with sleep and is bullied at school. You wonder if methotrexate would reduce the severity of EW's eczema. Structured clinical question In children with severe eczema, does methotrexate ...
Source: Archives of Disease in Childhood - July 17, 2015 Category: Pediatrics Authors: Scott, M., Lakshman Tags: ADC Archimedes, Oncology, Immunology (including allergy), Vaccination / immunisation, Child health, Physiotherapy, Dermatology, Undergraduate Source Type: research

Progress in Pediatrics in 2012: choices in allergy, endocrinology, gastroenterology, hematology, infectious diseases, neurology, nutrition and respiratory tract illnesses
In this review, we summarize the progresses in allergy, endocrinology, gastroenterology, hematology, infectious diseases, neurology, nutrition and respiratory tract illnesses that have been published in The Italian Journal of Pediatrics in 2012. The induction of Treg activity by probiotics might be effective for promoting tolerance towards food allergens. Nasal cytology is useful in patients with rhinitis for diagnosing chronic non-allergic non-infectious diseases. Atopic eczema is associated both with an aberrant skin matrix and impaired systemic immune response. Therefore, isolated topical treatment may have suboptimal e...
Source: Italian Journal of Pediatrics - May 8, 2013 Category: Pediatrics Authors: Carlo CaffarelliFrancesca SantamariaAlessandra VotteroSergio Bernasconi Source Type: research