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Repetitive verbal behaviors are not always harmful signs: Compensatory plasticity within the language network in aphasia.
Abstract Repetitive verbal behaviors such as conduite d'approche (CdA) and mitigated echolalia (ME) are well-known phenomena since early descriptions of aphasia. Nevertheless, there is no substantial fresh knowledge on their clinical features, neural correlates and treatment interventions. In the present study we take advantage of three index cases of chronic fluent aphasia showing CdA, ME or both symptoms to dissect their clinical and neural signatures. Using multimodal neuroimaging (structural magnetic resonance imaging and [18]-fluorodeoxyglucose positron emission tomography during resting state), we found that...
Source: Brain and Language - January 18, 2019 Category: Neurology Authors: Torres-Prioris MJ, López-Barroso D, Roé-Vellvé N, Paredes-Pacheco J, Dávila G, Berthier ML Tags: Brain Lang Source Type: research

The unbridged gap between clinical diagnosis and contemporary research on aphasia: A short discussion on the validity and clinical utility of taxonomic categories.
Abstract Even if the traditional aphasia classification is continuously questioned by many scholars, it remains widely accepted among clinicians and included in textbooks as the gold standard. The present study aims to investigate the validity and clinical utility of this taxonomy. For this purpose, 65 left-hemisphere stroke patients were assessed and classified with respect to aphasia type based on performance on a Greek adaptation of the Boston Diagnostic Aphasia Examination. MRI and/or CT scans were obtained for each patient and lesions were identified and coded according to location. Results indicate that 26.5...
Source: Brain and Language - October 30, 2016 Category: Neurology Authors: Kasselimis DS, Simos PG, Peppas C, Evdokimidis I, Potagas C Tags: Brain Lang Source Type: research

Intensive therapy induces contralateral white matter changes in chronic stroke patients with Broca's aphasia.
Abstract Using a pre-post design, eleven chronic stroke patients with large left hemisphere lesions and nonfluent aphasia underwent diffusion tensor imaging and language testing before and after receiving 15weeks of an intensive intonation-based speech therapy. This treated patient group was compared to an untreated patient group (n=9) scanned twice over a similar time period. Our results showed that the treated group, but not the untreated group, had reductions in fractional anisotropy in the white matter underlying the right inferior frontal gyrus (IFG, pars opercularis and pars triangularis), the right posterio...
Source: Brain and Language - July 17, 2014 Category: Neurology Authors: Wan CY, Zheng X, Marchina S, Norton A, Schlaug G Tags: Brain Lang Source Type: research