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FV 13 Electrophysiological correlates of language recovery – an MEG study of neuroplasticity in chronic post stroke aphasia
Previous studies have demonstrated that efficient language and communication therapy in chronic post stroke aphasia leads to significant clinical language improvements (Pulverm üller et al., 2001) and promotes neuroplasticity. Brain areas frequently associated with functional restitution of language comprise perilesional sites in the left hemisphere (MacGregor et al., 2015) as well as right-hemispheric regions, homotopic to those lesioned in the left (Mohr et al., 2014). To date, however, the neuronal mechanisms underlying therapy-induced language changes and functional restitution are still largely unclear.
Source: Clinical Neurophysiology - September 8, 2017 Category: Neuroscience Authors: B. Mohr, S. Difrancesco, L. MacGregor, Y. Shtyrov Tags: Free Lecture Source Type: research

P 165 Incidence, clinical characteristics and longterm course of headache in patients with stroke (DMKG multicenter study)
Post stroke headache is a symptom which is generally not further differentiated. According to previous European and American studies, it is a common phenomenon. Nevertheless, other symptoms of stroke, such as palsy or aphasia, are dominating clinical assessments. However, the symptom “headache” can be an essential part of the clinical picture as in subarachnoid bleeding or cerebral venous thrombosis and it is unclear which risk factors modulate the symptoms and the occurrence of headache in stroke.
Source: Clinical Neurophysiology - September 8, 2017 Category: Neuroscience Authors: S. Dietrich, A. D üring, D. Rothkirch, F. Filippopulos, O. Eren, T. Dresler, T. Buchwald, A. Straube, S. Zierz, G. Goßrau, T. Kraya Tags: Poster Source Type: research

112. Low frequency repetitive transcranial magnetic stimulation in early phase of rehabilitation of patients with post-stroke aphasia
About 50% of post-stroke patients remain aphasic a condition that greatly impede their reintegration to society. Results of Repetitive Transcranial Magnetic Stimulation (rTMS) as supplementary treatment for sub-acute post-stroke aphasia are controversial. We assessed the efficacy of inhibitory rTMS with conventional speech therapy to help recovery language performance in sub-acute stroke aphasia.In a randomised case-control double-blind study 12 non-fluent aphasic were consecutively enrolled. All patients suffered a first-ever stroke in the sub-acute stage defined as time since lesion onset from 1 month post-stroke.
Source: Clinical Neurophysiology - December 13, 2014 Category: Neuroscience Authors: R. Carrai, A. Grippo, A. Angelini, A. Vettori, T. Atzori, C. Falsini, M. Martini, A. Pizzi Source Type: research

146. Excitatory deep transcranial magnetic stimulation with H-coil over the right homologous Broca’s region improves naming in chronic post-stroke aphasia
This study aimed to compare the effect of excitatory, inhibitory and sham rTMS delivered with H-coil over the right inferior frontal gyrus (IFG) in chronic aphasic patients. Five right-handed post-stroke aphasic patients underwent a picture naming task before and immediately after each of three sessions of rTMS: excitatory (10Hz), inhibitory (1Hz) and sham rTMS, in random sequence and separated by at least 1 week. Only the excitatory 10Hz stimulation was associated with a significant improvement in naming performance, (p=0.043) and was significantly more effective than 1Hz rTMS (p=0.043). A single session of excitatory dee...
Source: Clinical Neurophysiology - October 21, 2013 Category: Neuroscience Authors: R. Chieffo, F. Ferrari, P. Battista, E. Houdayer, A. Nuara, F. Alemanno, J. Abutalebi, A. Zangen, G. Comi, S.F. Cappa, L. Leocani Tags: Society Proceedings Source Type: research

P 240. Improvement of language functions in a chronic non-fluent post-stroke aphasic patient following sequential bilateral non-invasive neuromodulation by theta burst magnetic stimulation
Conclusions: Described sequential bilateral physiologically balanced TMS modulation of activation of the language related areas of both hemispheres may result in considerable and rather fast language benefits in chronic nfA patients. Whether this approach is better than usual unilateral stimulation requires further studies.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: S. Filipovic, V. Stevanovic, I. Avramovic, M. Jelic, I. Avramovic, A. Jeremic, K. Kacar, S. Milanovic, L. Konstantinovic, J. Vuksanovic Tags: Society Proceedings Source Type: research

P 126. Righthemispheric inhibitory rTMS in patients with letfsided brain infarcts: Effect on cerebral blood flow using PET and speech performance
Discussion: rTMS with inhibitory effect on the rightsided homologous speech area plus speech therapy in patients with left sided brain infarcts and aphasia results in better recovery of language performance compared to patients who received speech therapy only.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: A. Hartmann, I. Rubi-Fessen, W.-D. Heiß, L. Kracht, J. Kessler, T. Rommel Tags: Society Proceedings Source Type: research

P 102. Transcranial direct current stimulation for improving aphasia after stroke. First results of a systematic Cochrane Review
Conclusion: Our review showed that in some studies tDCS might facilitate word retrieval after stroke and hence might improve aphasia. However, it is still unclear if tDCS could improve functional communication. Thus further research seems to be needed.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: B. Elsner, J. Kugler, M. Pohl, J. Mehrholz Tags: Society Proceedings Source Type: research

P 114. Anodal transcranial direct current stimulation in early treatment of post-stroke non-fluent aphasia
Conclusions: The findings provide only a weak evidence of A-tDCS behavioural gains during early neurorehabilitation of post-stroke aphasia. Further research is needed to investigate the effectiveness of this kind of neuromodulation. Different modes and parameters of tDCS should be explored considering such important factors determining recovery from aphasia as type and severity of language impairment, lesion site and size, time since stroke, and degree of hemispheric language laterality.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: K. Polanowska, M. Leśniak, J. Seniów Tags: Society Proceedings Source Type: research

IS 39. Enhanced visuo-spatial and language learning with tDCS
Efficacy and effectiveness of training in conditions like chronic post-stroke aphasia or neglect, or neurodegenerative disorders like mild cognitive impairment (MCI) and Alzheimer’s disease, remain moderate only. Thus, novel strategies to enhance training success and overall behavioural outcome are urgently needed. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation tool that is now being widely used in neuroscientific and clinical research in humans, modulating cortical excitability by application of weak electrical currents in the form of direct current brain polarization.In a series of st...
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: A. Flöel, W. Suttorp, M. Meinzer, C. Breitenstein Tags: Society Proceedings Source Type: research

IS 27. Brain stimulation in stroke therapy
Non-invasive brain stimulation has shown its potential to modulate brain plasticity and enhance the effects of training in humans (Zimerman et al., Ann Neurol; 2012). Endeavour has been made to utilize brain stimulation in neurological diseases to enhance adaptive processes and prevent potential maladaptive ones. First studies presented evidence that non-invasive brain stimulation might not only transiently improve functions of the paretic hand, but can also modulate processes of learning (Zimerman et al., Stroke; 2012), a basis to achieve longer lasting effects. Based on this enhancement of functional recovery of both, se...
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: F.C. Hummel Tags: Society Proceedings Source Type: research

P 240. Improvement of language functions in a chronic non-fluent post-stroke aphasic patient following sequential bilateral non-invasive neuromodulation by theta burst magnetic stimulation
Conclusions: Described sequential bilateral physiologically balanced TMS modulation of activation of the language related areas of both hemispheres may result in considerable and rather fast language benefits in chronic nfA patients. Whether this approach is better than usual unilateral stimulation requires further studies.
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: S. Filipovic, V. Stevanovic, I. Avramovic, M. Jelic, I. Avramovic, A. Jeremic, K. Kacar, S. Milanovic, L. Konstantinovic, J. Vuksanovic Tags: Society Proceedings Source Type: research

P 114. Anodal transcranial direct current stimulation in early treatment of post-stroke non-fluent aphasia
Conclusions: The findings provide only a weak evidence of A-tDCS behavioural gains during early neurorehabilitation of post-stroke aphasia. Further research is needed to investigate the effectiveness of this kind of neuromodulation. Different modes and parameters of tDCS should be explored considering such important factors determining recovery from aphasia as type and severity of language impairment, lesion site and size, time since stroke, and degree of hemispheric language laterality.
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: K. Polanowska, M. Leśniak, J. Seniów Tags: Society Proceedings Source Type: research

P 126. Righthemispheric inhibitory rTMS in patients with letfsided brain infarcts: Effect on cerebral blood flow using PET and speech performance
Discussion: rTMS with inhibitory effect on the rightsided homologous speech area plus speech therapy in patients with left sided brain infarcts and aphasia results in better recovery of language performance compared to patients who received speech therapy only.
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: A. Hartmann, I. Rubi-Fessen, W.-D. Heiß, L. Kracht, J. Kessler, T. Rommel Tags: Society Proceedings Source Type: research

P 102. Transcranial direct current stimulation for improving aphasia after stroke. First results of a systematic Cochrane Review
Conclusion: Our review showed that in some studies tDCS might facilitate word retrieval after stroke and hence might improve aphasia. However, it is still unclear if tDCS could improve functional communication. Thus further research seems to be needed.
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: B. Elsner, J. Kugler, M. Pohl, J. Mehrholz Tags: Society Proceedings Source Type: research

IS 27. Brain stimulation in stroke therapy
Non-invasive brain stimulation has shown its potential to modulate brain plasticity and enhance the effects of training in humans (Zimerman et al., Ann Neurol; 2012). Endeavour has been made to utilize brain stimulation in neurological diseases to enhance adaptive processes and prevent potential maladaptive ones. First studies presented evidence that non-invasive brain stimulation might not only transiently improve functions of the paretic hand, but can also modulate processes of learning (Zimerman et al., Stroke; 2012), a basis to achieve longer lasting effects. Based on this enhancement of functional recovery of both, se...
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: F.C. Hummel Tags: Society Proceedings Source Type: research

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