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Total and specific fruit and vegetable consumption and risk of stroke: A prospective study
Conclusion: This study shows an inverse association of fruit and vegetable consumption with stroke risk. Particularly consumption of apples and pears and green leafy vegetables was inversely associated with stroke.Highlights: ► Fruit and vegetables is a heterogeneous food group with different content of nutrients. ► It remains unclear which fruit and vegetable subgroups that are most protective against stroke. ► We examined the relation between fruit and vegetable consumption and stroke risk. ► Particularly consumption of apples/pears and green leafy vegetables was inversely associated with stroke.
Source: Atherosclerosis - January 7, 2013 Category: Cardiology Authors: Susanna C. Larsson, Jarmo Virtamo, Alicja Wolk Tags: Epidemiology, Biomarkers, Nutrition Source Type: research

Ankle–brachial index predicts stroke in the general population in addition to classical risk factors
Abstract: Background: Predictors of future stroke events gain importance in vascular medicine. Herein, we investigated the value of the ankle-brachial index (ABI), a simple non-invasive marker of atherosclerosis, as stroke predictor in addition to established risk factors that are part of the Framingham risk score (FRS).Methods: 4299 subjects from the population-based Heinz Nixdorf Recall study (45–75 years; 47.3% men) without previous stroke, coronary heart disease or myocardial infarcts were followed up for ischemic and hemorrhagic stroke events over 109.0 ± 23.3 months. Cox proportional hazard regressions were used...
Source: Atherosclerosis - March 20, 2014 Category: Cardiology Authors: Janine Gronewold, Dirk M. Hermann, Nils Lehmann, Knut Kröger, Karl Lauterbach, Klaus Berger, Christian Weimar, Hagen I.M. Kälsch, Susanne Moebus, Karl-Heinz Jöckel, Marcus Bauer, Raimund Erbel, Heinz Nixdorf Recall Study Investigative Group Tags: Clinical & Population Research - Epidemiology, Biomarkers, Nutrition Source Type: research

Comparative mortality according to peripheral artery disease and coronary heart disease/stroke in the United States
A recent trial reported that patients with peripheral artery disease (PAD) without coronary heart disease or stroke (CHD/stroke) had worse prognosis than those with CHD/stroke without PAD. However, community-based data are lacking. The purpose of this study was to compare mortality according to the status of PAD and CHD/stroke in the general population.
Source: Atherosclerosis - May 8, 2022 Category: Cardiology Authors: Kunihiro Matsushita, Yumin Gao, Yingying Sang, Shoshana H. Ballew, Maya Salameh, Matthew Allison, Elizabeth Selvin, Josef Coresh Source Type: research

Similarities and differences between coronary heart disease and stroke in the associations with cardiovascular risk factors: The Japan collaborative cohort study
Coronary heart disease (CHD) and stroke have common risk factors, but some of these differ in the magnitude or direction of associations between CHD and stroke. We assessed whether the impact of each risk factor differed between CHD and stroke mortality in Asians.
Source: Atherosclerosis - March 4, 2017 Category: Cardiology Authors: Masaaki Matsunaga, Hiroshi Yatsuya, Hiroyasu Iso, Kentaro Yamashita, Yuanying Li, Kazumasa Yamagishi, Naohito Tanabe, Yasuhiko Wada, Chaochen Wang, Atsuhiko Ota, Koji Tamakoshi, Akiko Tamakoshi, The JACC Study Group Source Type: research

Lipoprotein(a) level, apolipoprotein(a) size, and risk of unexplained ischemic stroke in young and middle-aged adults
We examined the role of Lp(a) in younger adults with cryptogenic stroke.
Source: Atherosclerosis - August 20, 2016 Category: Cardiology Authors: Azadeh Beheshtian, Sanyog G. Shitole, Alan Z. Segal, Dana Leifer, Russell P. Tracy, Daniel J. Rader, Richard B. Devereux, Jorge R. Kizer Source Type: research

Lipoprotein (a) level, apolipoprotein (a) size, and risk of unexplained ischemic stroke in young and middle-aged adults
We examined the role of Lp(a) in younger adults with cryptogenic stroke.
Source: Atherosclerosis - August 20, 2016 Category: Cardiology Authors: Azadeh Beheshtian, Sanyog G. Shitole, Alan Z. Segal, Dana Leifer, Russell P. Tracy, Daniel J. Rader, Richard B. Devereux, Jorge R. Kizer Source Type: research

Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: The Hisayama Study
Abstract: Background and purpose: It has not been fully determined whether non-high-density lipoprotein cholesterol (non-HDLC) levels are involved in vascular events, especially stroke, in general Asian populations. We evaluated the association between non-HDLC levels and the risk of type-specific cardiovascular disease in a prospective cohort study in Japan.Methods: A total of 2452 community-dwelling Japanese subjects aged ≥40 years were followed prospectively for 24 years.Results: The age- and sex-adjusted incidence of coronary heart diseases (CHD) significantly increased with elevating non-HDLC levels (P for trend 
Source: Atherosclerosis - March 20, 2014 Category: Cardiology Authors: Tsuyoshi Imamura, Yasufumi Doi, Toshiharu Ninomiya, Jun Hata, Masaharu Nagata, Fumie Ikeda, Naoko Mukai, Yoichiro Hirakawa, Daigo Yoshida, Masayo Fukuhara, Takanari Kitazono, Yutaka Kiyohara Tags: Clinical & Population Research - Epidemiology, Biomarkers, Nutrition Source Type: research

Statins decrease the risk of stroke in individuals with heterozygous familial hypercholesterolemia: a systematic review and meta-analysis
Familial hypercholesterolemia (FH) is undoubtedly associated with premature coronary heart disease, but it is debatable whether FH increases the risk for stroke.
Source: Atherosclerosis - September 1, 2015 Category: Cardiology Authors: Fotios Barkas, Moses Elisaf, Haralampos Milionis Tags: Review article Source Type: research

Lack of association of plasma factor XI with incident stroke and coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study
We examined the association of factor XI with incident stroke and coronary heart disease in the prospective Atherosclerosis Risk in Communities (ARIC) Study.
Source: Atherosclerosis - September 10, 2015 Category: Cardiology Authors: Aaron R. Folsom, Kristen M. George, Duke Appiah Source Type: research

Trends in the proportions of stroke subtypes and coronary heart disease in the Japanese men and women from 1995–2009
The limited evidence on trends in the proportions of stroke subtypes and coronary heart disease in Japan.
Source: Atherosclerosis - March 3, 2016 Category: Cardiology Authors: Renzhe Cui, Hiroyasu Iso, Kazumasa Yamagishi, Isao Saito, Yoshihiro Kokubo, Manami Inoue, Norie Sawada, Shoichiro Tsugane, the JPHC Study Group Source Type: research

Association of high-density lipoprotein cholesterol concentration with different types of stroke and coronary heart disease: The Japan Public Health Center-based prospective (JPHC) study
Although low high-density lipoprotein (HDL) cholesterol concentration is an established risk factor for coronary heart disease (CHD), information regarding subtypes of stroke is very limited, especially in Asian populations.
Source: Atherosclerosis - September 1, 2017 Category: Cardiology Authors: Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Hiroyasu Iso, Norie Sawada, Manami Inoue, Shoichiro Tsugane Source Type: research

Weight change during middle age and risk of stroke and coronary heart disease: The Japan Public Health Center –based Prospective Study
The impact of weight changes in middle age on the incidence of cardiovascular disease has not been well elucidated. We investigated whether a 5-year weight change was associated with risk of stroke and coronary heart disease (CHD) in middle-aged individuals.
Source: Atherosclerosis - February 23, 2021 Category: Cardiology Authors: Koichi Kisanuki, Isao Muraki, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Norie Sawada, Hiroyasu Iso, Shoichiro Tsugane, for the JPHC Study Group Source Type: research

Obstructive sleep apnea and cardiovascular risk: Meta-analysis of prospective cohort studies
Conclusions: In conclusion, findings from this meta-analysis supported that moderate-severe OSA significantly increased cardiovascular risk, in particular stroke risk.
Source: Atherosclerosis - May 16, 2013 Category: Cardiology Authors: Jia-Yi Dong, Yong-Hong Zhang, Li-Qiang Qin Tags: Reviews Source Type: research

MicroRNA-616 and atherosclerosis – A commentary on the paper by Liu et al.
MicroRNAs (miRNA, miR) in cardiovascular diseases are a constantly growing field. As individual microRNAs are predicted to regulate the expression of hundreds of genes, and a single gene can be targeted by numerous microRNAs, microRNA profiling can rarely indicate the mechanism through which microRNAs affect the disease. In their paper “A functional polymorphism of PON1 interferes with microRNA binding to increase the risk of ischemic stroke and carotid atherosclerosis”, Liu et al. have shown a decreased binding affinity of miR-616 to the 3′-UTR as well as an increased paraoxonase 1 (PON1) expression in a plasmid co...
Source: Atherosclerosis - March 6, 2013 Category: Cardiology Authors: Emma Raitoharju Tags: Invited Commentaries Source Type: research

Leukocytes, platelets and cardiovascular diseases
We read with great interest the recent article in Atherosclerosis by Xu et al. [1]. In a large prospective study comprising 13,929 middle age and elderly individuals of Chinese descent, they showed that the systemic immune-inflammation index (SII), the product of the neutrophil count x platelet count x lymphocyte count, predicted total stroke, ischemic stroke and hemorrhagic stroke over a median follow-up of 8.3 years using multivariate Cox regression analyses [1]. Although there was a threefold increase in coronary heart disease (CAD), SII did not predict CAD or acute coronary syndromes (ACS).
Source: Atherosclerosis - May 7, 2021 Category: Cardiology Authors: Ishwarlal Jialal, Beverley Adams-Huet Tags: Correspondence Source Type: research

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