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Prior chronic clopidogrel therapy is associated with increased adverse events and early stent thrombosis.
Abstract Despite the growing use of clopidogrel, limited data exist regarding the prognostic significance of chronic clopidogrel therapy in patients sustaining acute coronary syndrome (ACS). Our aim was to determine whether patients sustaining ACS while on chronic clopidogrel therapy have a worse prognosis than clopidogrel-naïve patients. A total of 5,386 consecutive ACS patients were prospectively characterised and followed-up for 30 days. Of them, 680 (13 %) were treated with clopidogrel prior to the index ACS. Major adverse cardiovascular events (MACE) were defined as death, recurrent ACS, stroke and/or sten...
Source: Thrombosis and Haemostasis - October 8, 2015 Category: Hematology Authors: Asher E, Fefer P, Sabbag A, Herscovici R, Regev E, Mazin I, Shlomo N, Zahger D, Atar S, Hammerman H, Polak A, Beigel R, Matetzky S, PLATIS (Platelets and Thrombosis in Sheba) Study Group Tags: Thromb Haemost Source Type: research

Prevalence and impact of carotid disease in adult Saudi patients undergoing isolated coronary artery bypass surgery on early postoperative outcome
The aim of the study is to assess the prevalence of carotid disease in our Saudi population undergoing coronary artery bypass surgery and to determine its impact on stroke and early postoperative outcome. A total of 3197 consecutive adult patients underwent major cardiac surgery in our center between January 2002 and December 2012. Of these, 3150 had preoperative duplex scanning, and out of these, 210 patients (6.6%) had significant carotid artery disease defined as ≥75% stenosis (Group A), whereas 2940 (94.4%) were free from carotid artery disease (Group B). Both groups were compared for the presence of preoperative ri...
Source: European Journal of Heart Failure Supplements - November 10, 2014 Category: Cardiology Authors: Arifi, A. A., Ahmad, M., Van Onselen, R., Najm, H. K. Tags: Articles Source Type: research