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Estimated glomerular filtration rate and incident stroke in patients with hypertension and/or diabetes
Sarfo et al. conducted a prospective study to evaluate the effect of estimated glomerular filtration rate (eGFR) on incident stroke in patients with hypertension and/or type 2 diabetes mellitus [1]. The authors had reported the risk factors of incident stroke in patients with hypertension and/or type 2 diabetes mellitus by using the same database [2]. They recognized 54 events of stroke and stroke incidence rates increased with decreasing eGFR. Adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of eGFR with 60 –89 ml/min, 30–59 ml/min, and89  ml/min for incident stroke were 1.42 (0.63–3.21), 1.88 (1....
Source: Journal of the Neurological Sciences - December 27, 2018 Category: Neurology Authors: Tomoyuki Kawada Tags: Letter to the Editor Source Type: research

Matrix metalloproteinase-1 and matrix metalloproteinase-12 gene polymorphisms and the risk of ischemic stroke in a Tunisian population
In this study, we investigated, for the first time, the association between MMP-1-16071G/2G, MMP-12 -82A/G and MMP-12 1082A/G genotypes and haplotypes and the risk of ischemic stroke (IS) among patients with type 2 diabetes mellitus (T2DM). To examine whether these genetic polymorphisms are associated with susceptibility to IS, 196 patients with IS and 192 controls were examined by PCR-based RFLP. When the analyses were adjusted for multiple risk factors, no interaction between T2DM and MMP-1-1607 1G/2G polymorphism on the risk of ischemic stroke was found (p=0.074). However, MMP-12 polymorphisms genotypes were associated ...
Source: Journal of the Neurological Sciences - May 16, 2014 Category: Neurology Authors: Khouloud Chehaibi, Mohamed Yahia Hrira, Samir Nouira, Faouzi Maatouk, Khaldoun Ben Hamda, Mohamed Naceur Slimane Tags: Original Articles Source Type: research

Comparative effects of low-dose versus standard-dose alteplase in ischemic patients with prior stroke and/or diabetes mellitus: The ENCHANTED trial
History of prior stroke (PS) and diabetes mellitus (DM) are considered relative contraindications to the use of intravenous alteplase in patients with acute ischemic stroke (AIS). We aimed to assess whether a history of PS and DM modified the comparative effects of low- versus standard-dose alteplase in patients who participated in the alteplase-dose arm of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED).
Source: Journal of the Neurological Sciences - January 11, 2018 Category: Neurology Authors: Guofang Chen, Xia Wang, Thompson G. Robinson, Richard I. Lindley, Shengkui Zhou, Lei Ping, Weiwei Liu, Leijing Liu, John Chalmers, Craig S. Anderson, for the ENCHANTED Investigators Source Type: research

Estimated glomerular filtration rate predicts incident stroke among ghanaians with diabetes and hypertension
This study sought to fill this knowledge gap.
Source: Journal of the Neurological Sciences - September 20, 2018 Category: Neurology Authors: Fred Stephen Sarfo, Linda Meta Mobula, Osei Sarfo-Kantanka, Sheila Adamu, Jacob Plange-Rhule, Daniel Ansong, Rexford Adu Gyamfi, James Duah, Bertha Abraham, David Ofori-Adjei Source Type: research

Estimated glomerular filtration rate predicts incident stroke among Ghanaians with diabetes and hypertension
This study sought to fill this knowledge gap.
Source: Journal of the Neurological Sciences - November 15, 2018 Category: Neurology Authors: Fred Stephen Sarfo, Linda Meta Mobula, Osei Sarfo-Kantanka, Sheila Adamu, Jacob Plange-Rhule, Daniel Ansong, Rexford Adu Gyamfi, James Duah, Bertha Abraham, David Ofori-Adjei Tags: Clinical short communication Source Type: research

Response by Sarfo to letter regarding “Patients with hypertension and/or diabetes and incident stroke: A risk assessment”
We sincerely thank Dr. Kawada for his interest in our study titled ‘Incident stroke among Ghanaians with hypertension and diabetes: a multicenter, prospective study’. The aim of our study [1] was to assess the rates and determinants of incident stroke among a prospective, hospital-based Ghanaian cohort with hypertension and or type 2 diabetes mellitus. In this regard, our study was not designed to “evaluate the risk of hypertension and diabetes for incident stroke” as specified by our correspondents.
Source: Journal of the Neurological Sciences - December 13, 2018 Category: Neurology Authors: Fred S. Sarfo Tags: Letter to the Editor Source Type: research

Characterisation of recent trends in cardiovascular risk factors in young and middle-aged patients with ischaemic stroke and/or transient ischaemic attack
Strokes in the young and middle-aged are associated with a disproportionately large economic and social impact in addition to their clinical effects. Standard Modifiable Cardiovascular Risk Factors (SMuRFs; hypercholesterolaemia, hypertension, diabetes mellitus and smoking) are key drivers of cardiovascular disease including strokes, however recent temporal trends in the younger stroke population have not been well characterised. We aimed to evaluate recent trends of SMuRFs in a cohort of younger patients with ischaemic stroke.
Source: Journal of the Neurological Sciences - September 1, 2020 Category: Neurology Authors: Aditya Bhat, Gary C.H. Gan, David Makarious, Elizabeth Tan, Henry H.L. Chen, Nigel Wolfe, Lina Lee, Camelia Burdusel, Maria Carmo P. Nunes, Clara K. Chow, Timothy C. Tan Source Type: research

Etiological mechanisms of isolated pontine infarcts based on arterial territory involvement
Conclusions: Baseline characteristics were significantly different among patients with isolated pontine infarcts in different topographic locations. Our results suggest that cardioembolism is relatively common in lateral or posterior pontine infarcts, whereas basilar artery atherosclerosis is more common in anteromedial infarcts.
Source: Journal of the Neurological Sciences - February 24, 2014 Category: Neurology Authors: Junpei Kobayashi, Tomoyuki Ohara, Kazuo Minematsu, Kazuyuki Nagatsuka, Kazunori Toyoda Tags: Original Articles Source Type: research

Unusual case of cerebral small vessel disease with a heterozygous nonsense mutation in
Cerebral small vessel disease (CSVD) is a heterogeneous group of disorders with a predisposition for lacunar infarcts and white matter lesions. It is one of the main causes of ischemic stroke and cognitive impairment among the elderly. Several monogenic conditions cause the rare inherited forms of CSVD, which are distinguishable from many others associated with common cerebrovascular risk factors such as hypertension or diabetes mellitus on the basis of family history, onset in early adulthood, or syndromic presentation [1].
Source: Journal of the Neurological Sciences - January 20, 2016 Category: Neurology Authors: Toru Tateoka, Hideaki Onda, Kengo Hirota, Hidetoshi Kasuya, Toyoaki Shinohara, Hiroyuki Kinouchi, Hiroyuki Akagawa Source Type: research

Hemichorea-hemiballismus in the setting of posterolateral putaminal lesion and treatment with topiramate
A-60year old female with medical history of hypertension, diabetes mellitus (with good glycemic control) and hyperlipidemia suffered from right sided involuntary movements of upper and lower extremities progressing over the past 4years (Video 1). She had had an ischemic stroke characterized with right sided weakness 8years ago. Motor examinations revealed 4+/5 motor weakness solely in the right triceps muscle and her walking was antalgic due to gonarthrosis. Cranial MRI showed chronic ischemic lesion in the left thalamic and posterior putamen (Fig.
Source: Journal of the Neurological Sciences - February 13, 2017 Category: Neurology Authors: Halil Onder Tags: Letter to the Editor Source Type: research

Circulating autoantibodies against the NR2 peptide of the NMDA receptor are associated with subclinical brain damage in hypertensive patients with other pre-existing conditions for vascular risk
Arterial hypertension (HT) and other vascular pre-existing conditions (PEC) generate asymptomatic brain damage which increases the occurrence of stroke and cognitive decline. The aim of this work was to explore if serum antibodies against the NR2 subunit of the NMDA receptor (NR2Ab) could predict subclinical brain damage (SBD) in hypertensive patients with PEC. Forty seven neurologically asymptomatic hypertensive subjects were classified according to the number of PEC (retinopathy, overweight/obesity, diabetes mellitus and dyslipidemia).
Source: Journal of the Neurological Sciences - February 13, 2017 Category: Neurology Authors: S. Gonz ález-García, A. González-Quevedo, Z. Hernandez-Diaz, L. Alvarez Camino, M. Peña-Sanchez, A. Cordero-Eiriz, M. Brown, J.A. Gaya, M. Betancourt-Losa, I. Fernandez-Almirall, M.C. Menendez-Sainz, R. Fernandez-Carriera Source Type: research

Delayed leukoencephalopathy after recanalized cardioembolic stroke: Two case reports
A 66-year-old man with a history of hypertension, dyslipidemia, diabetes mellitus, and myocardial infarction was admitted to our hospital due to sudden somnolence, global aphasia, right spatial neglect, and right hemiparesis. Diffusion weighted images (DWI) revealed no hyperintense lesions (Fig. 1A, B). Magnetic resonance angiography (MRA) demonstrated an occlusion of the left middle cerebral artery (MCA). The patient was treated with intravenous tissue plasminogen activator and endovascular therapy using the Penumbra ™ 3MAX and 5MAX ACE catheters, leading to successful recanalization of the MCA 287min after symptom onse...
Source: Journal of the Neurological Sciences - May 25, 2017 Category: Neurology Authors: Takaomi Singu, Yuichiro Inatomi, Toshiro Yonehara, Yukio Ando Tags: Letter to the Editor Source Type: research

Prevalence and predictors of statin utilization among patient populations at high vascular risk in Ghana
Inadequate implementation of evidence-based preventive measures for individuals at high risk of cardiovascular disease (CVD) will only worsen the current epidemic of CVDs in sub-Saharan Africa. We assessed rates and predictors of statin utilization among two high CVD risk patient populations, people with type 2 diabetes mellitus (T2DM) and those with stroke, encountered across five hospitals in Ghana.
Source: Journal of the Neurological Sciences - April 14, 2020 Category: Neurology Authors: Fred Stephen Sarfo, Bruce Ovbiagele Source Type: research

A one-year longitudinal evaluation of cerebrospinal fluid and blood neurochemical markers in a patient with cryptococcal meningitis complicated by ischemic stroke.
Cryptococcal meningitis (CCM) is caused by the encapsulated basidiomycetous yeast Cryptococcus neoformans and is one of the most common central nervous system (CNS) infections in immunocompromised subjects [1 –4]. In this regard, autoimmune diseases, sarcoidosis, glucocorticoid treatment, solid-organ transplantation, hematologic malignancies, diabetes mellitus, chronic renal failure are well-known predisposing factors for CCM in HIV-negative patients [1–4]. Sources of C. neoformans are excrement of b irds such as pigeons, contaminated soil, and the bark of several tree species [1].
Source: Journal of the Neurological Sciences - December 13, 2021 Category: Neurology Authors: Samir Abu-Rumeileh, Tamara Garibashvili, J ürgen Benjamin Hagemann, Veronika Still, Franziska Bachhuber, Markus Otto, Hayrettin Tumani, Makbule Senel Tags: Letter to the Editor Source Type: research