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Source: FASEB Journal
Condition: Diabetes Mellitus
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Total 1 results found since Jan 2013.
Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/{beta}-catenin signaling pathway in human pancreatic {beta} cells Research
Diabetes mellitus is a complex and heterogeneous disease, which has β-cell dysfunction at its core. Glucotoxicity affects pancreatic islets, causing β-cell apoptosis. However, the role of JNK/β-catenin signaling in glucotoxic β-cell apoptosis is not well understood. Recently, we identified tetraspanin-2 (TSPAN2) protein as a proapoptotic β-cell factor induced by glucose, suggesting that TSPAN2 might contribute to pancreatic β-cell glucotoxicity. To investigate the effects of glucose concentration on TSPAN2 expression and apoptosis, we used reverted immortalized RNAKT-15 human pancreatic β...
Source: FASEB Journal - August 31, 2016 Category: Biology Authors: Hwang, I.-H., Park, J., Kim, J. M., Kim, S. I., Choi, J.-S., Lee, K.-B., Yun, S. H., Lee, M.-G., Park, S. J., Jang, I.-S. Tags: Research Source Type: research
