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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Dementia
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Total 74 results found since Jan 2013.
Cortical Microinfarcts in Patients with Middle Cerebral Artery Stenosis
Cortical microinfarcts (CMIs) have been correlated to cognitive decline and dementia. It was previously considered only visible on microscope, but was recently reported to be visible on 3.0 Tesla magnetic resonance imaging (MRI) and linked to presence of intracranial stenosis. We aimed to investigate CMIs on 3.0 Tesla MRI in patients with M1 middle cerebral artery (MCA-M1) stenosis.
Source: Journal of Stroke and Cerebrovascular Diseases - May 15, 2017 Category: Neurology Authors: Xinyi Leng, Hui Fang, Yuehua Pu, Xinying Zou, Yuesong Pan, Yannie O.Y. Soo, Yuming Xu, Chunxue Wang, Xingquan Zhao, Yilong Wang, Yongjun Wang, David S. Liebeskind, Lawrence K.S. Wong, Thomas W. Leung, Liping Liu, CICAS Study Group Source Type: research
Effect of Telmisartan on Preventing Learning and Memory Deficits Via Peroxisome Proliferator-Activated Receptor- γ in Vascular Dementia Spontaneously Hypertensive Rats
This study aimed to explore the effect of telmisartan (TEL), as a partial peroxisome proliferator-activated receptor- γ (PPAR-γ) agonist, in vascular dementia (VaD) rats induced by middle cerebral artery occlusion (MCAO).
Source: Journal of Stroke and Cerebrovascular Diseases - December 11, 2017 Category: Neurology Authors: Yuan Gao, Wei Li, Yali Liu, Yan Wang, Jianchao Zhang, Miao Li, Mengsen Bu Source Type: research
Qualitative Analysis of Mini Mental State Examination Pentagon in Vascular Dementia and Alzheimer's Disease: A Longitudinal Explorative Study
Vascular dementia and Alzheimer's disease are the most diffuse forms of dementia. Sometimes, they are difficult to distinguish due to overlaps in symptomatology, pathophysiology, and comorbidity. Visual constructive apraxia is very common in dementia and impairment in these abilities can provide clinical information for differential diagnosis.
Source: Journal of Stroke and Cerebrovascular Diseases - March 1, 2018 Category: Neurology Authors: Viviana Lo Buono, Lilla Bonanno, Francesco Corallo, Maria Foti, Rosanna Palmeri, Marra Angela, Giuseppe Di Lorenzo, Antonino Todaro, Placido Bramanti, Alessia Bramanti, Silvia Marino Source Type: research
A Novel NOTCH3 Gene Mutation in a Polish CADASIL Family
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a genetically determined disease of the cerebral vessels, characterized by recurrent ischemic strokes, dementia, and degeneration of the cerebral white matter. The condition is caused by a mutation in the NOTCH3 gene, whose product plays a great role in the development and physiology of the cardiovascular system. Magnetic resonance imaging reveals multiple hyperintensive lesions of the white matter in the T2-weighted images also in asymptomatic carriers of CADASIL and can be detected even 10-15 years prior to clinical signs.
Source: Journal of Stroke and Cerebrovascular Diseases - December 10, 2018 Category: Neurology Authors: Karolina Machowska- Sempruch, Anna Bajer- Czajkowska, Karol Makarewicz, Karolina Zarycza ńska, Adam Koryzma, Przemysław Nowacki Source Type: research
Cerebrovascular Correlates of Dementia in Community-Dwelling Older Adults Living in Rural Communities – The Three Villages Study. Rationale and Protocol of a Population-Based Prospective Cohort Study
Background: Despite the assumption that dementia is increasing in rural areas of Latin America, there is no information on the burden and risk factors leading to dementia in these settings. Aims: To assess prevalence and incidence of dementia, and its cerebrovascular correlates in an established cohort of community-dwelling older adults living in rural Ecuador, and to explore the impact of dementia on functional disability and the role of the social determinants of health in the above-mentioned relationships.
Source: Journal of Stroke and Cerebrovascular Diseases - February 3, 2020 Category: Neurology Authors: Oscar H. Del Brutto, Robertino M. Mera, Victor J. Del Brutto, Aldo F. Costa, Bettsy Y. Recalde Source Type: research
Mesial Frontal Lobe Infarction Presenting as Pisa Syndrome
Pisa syndrome is usually seen in patients with Alzheimer's disease treated with a cholinesterase inhibitor, dementia with Lewy bodies, Parkinson's disease, or atypical parkinsonism including multiple system atrophy. An 86-year-old woman presented with an acute onset of lateral flexion of her trunk to the left side, i.e., Pisa syndrome. She also showed left hemiparesis predominantly in her lower extremity. Her diffusion-weighted magnetic resonance images showed acute infarction in the right premotor area and supplementary motor area.
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: Kazuyuki Noda, Maya Ando, Takayuki Jo, Anri Hattori, Kotaro Ogaki, Mizuho Sugiyama, Nobutaka Hattori, Yasuyuki Okuma Tags: Case Report Source Type: research
Homocysteine is Associated with the Development of Cerebral Small Vessel Disease: Retrospective Analyses from Neuroimaging and Cognitive Outcomes
Cerebral small vessel disease (cSVD) includes a wide spectrum of pathological, neuroimaging, and clinical processes with various aetiologies that affect small arteries, arterioles, capillaries, and venules of the brain.1 With the intensified aging trend of the population, increased use of brain magnetic resonance imaging (MRI) has revealed heavy cSVD burdens, contributing to about 25% of ischaemic strokes, most haemorrhagic strokes, and nearly half of dementia cases in the world.2 Usually occult in onset, cSVD progresses slowly but finally induces complex consequences, posing a tough challenge to clinical management.
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2020 Category: Neurology Authors: Yifan Ji, Xiangyu Li, Zhenjie Teng, Xiaosha Li, Wei Jin, Pei yuan Lv Source Type: research
Association Between the Angiotensin-Converting Enzyme I/D Polymorphism and Risk of Cerebral Small Vessel Disease: A Meta-Analysis Based on 7186 Subjects
Cerebral small vessel disease (CSVD) causes a quarter of all strokes and is the most common pathology underlying vascular dementia. However, the mechanism of CSVD remains unclear. Numerous studies have investigated whether the angiotensin-converting enzyme (ACE) intersection/deletion (I/D) polymorphism influences the risk of CSVD, but the results are controversial.
Source: Journal of Stroke and Cerebrovascular Diseases - January 5, 2021 Category: Neurology Authors: Cheng Su, Wen-Chen Liu, Guo-Ming Li, Yan Huang Source Type: research
Emerging Concepts in Vascular Dementia: A Review
Vascular dementia (VaD) is the second most common cause of dementia and a major health concern worldwide. A comprehensive review on VaD is warranted for better understanding and guidance for the practitioner. We provide an updated overview of the epidemiology, pathophysiological mechanisms, neuroimaging patterns as well as current diagnostic and therapeutic approaches.
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2021 Category: Neurology Authors: Shyamal C. Bir, Muhammad W. Khan, Vijayakumar Javalkar, Eduardo Gonzalez Toledo, Roger E. Kelley Tags: Review Article Source Type: research
Sex Differences in the Relationship Between Arterial Stiffness and Cognitive Function in Older Adults
Currently, dementia is a public health priority. The World Health Organization estimates 50 million people worldwide have dementia and every year there are nearly 10 million new cases.1 Dementia is a major cause of disability and dependency among older adults.1 As such, a better understanding of the mechanisms underlying cognitive decline will aid in developing targeted therapies for treatment and prevention.
Source: Journal of Stroke and Cerebrovascular Diseases - October 26, 2021 Category: Neurology Authors: Elizabeth Dao, Cindy K. Barha, Mij Santos, Madison Welch, Teresa Liu-Ambrose Source Type: research
Quantitative Analysis of White Matter Hyperintensity: Comparison of Magnetic Resonance Imaging Image Analysis Software
White matter hyperintensity (WMH), defined as abnormal signals on magnetic resonance imaging (MRI), is an important clinical indicator of aging and dementia. Although MRI image analysis software can automatically detect WMH, the quantitative accuracy of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) is unknown.
Source: Journal of Stroke and Cerebrovascular Diseases - June 9, 2022 Category: Neurology Authors: Ken-ichi Tabei, Naoki Saji, Noriko Ogama, Makiko Abe, Saeko Omura, Takashi Sakurai, Hidekazu Tomimoto Tags: Short Communication Source Type: research
Associations between primary care electrocardiography and non-Alzheimer dementia
To determine whether electrocardiogram (ECG) markers are associated with incident non-Alzheimer's dementia (non-AD) and whether these markers also improve risk prediction for non-AD.
Source: Journal of Stroke and Cerebrovascular Diseases - July 10, 2022 Category: Neurology Authors: Jonas L. Isaksen, Jonas Ghouse, Morten W. Skov, Morten S. Olesen, Anders G. Holst, Adrian Pietersen, Jonas B. Nielsen, Anja Maier, Claus Graff, Ruth Frikke-Schmidt, J ørgen K. Kanters Source Type: research
Physical activity in vascular cognitive impairment: Systematic review with meta-analysis
Vascular cognitive impairment (VCI) is the second most common cause of cognitive impairment worldwide and includes a spectrum from vascular cognitive impairment no dementia (VCIND) to vascular dementia (VaD). There is no specific pharmacological treatment approved for VCI. Physical activity has been indicated to be a promising preventive measure for cognition, with direct as indirectly benefits, while improving several modifiable vascular risk factors, so potentially effective when considering VCI.
Source: Journal of Stroke and Cerebrovascular Diseases - May 6, 2023 Category: Neurology Authors: Joana V ítor, Catarina Melita, Mário Rodrigues, Diana Aguiar de Sousa, João Costa, JM Ferro, Ana Verdelho Source Type: research
