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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Dementia
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Total 74 results found since Jan 2013.
Volume of White Matter Hyperintensities, and Cerebral Micro-Bleeds
White matter hyperintensities (WMH) indicate the presence of patchy hyper-intense areas visible on FLAIR-MRI.1,2 WMH are visible in several neurological conditions, (cerebral small vessel disease, dementia, mood and cognitive disorders)3 –5 and these are associated with other pathologies such as stroke and hypertension.6 Moreover, their prevalence increases in elderly subjects.7 However, Pantoni et al.8 speculated that the clinical significance of WMH is not completely defined, and only most severe degrees of WMH seem to have an effect on cognitive functions.
Source: Journal of Stroke and Cerebrovascular Diseases - June 6, 2021 Category: Neurology Authors: Antonella Balestrieri, Pierleone Lucatelli, Harman S. Suri, Roberto Montisci, Jasjit S. Suri, Max Wintermark, Alessandra Serra, Xiaoguang Cheng, Cheng Jinliang, Roberto Sanfilippo, Luca Saba Source Type: research
One Disease with two Faces: Semidominant Inheritance of a Novel HTRA1 Mutation in a Consanguineous Family
Cerebral small vessel disease (CSVD) is a common form of neurological disease in elderly that leads to stroke, dementia, mood disturbance and gait problems. In the recent years, several inherited forms of CSVD have been recognized and linked to genes on autosomes and X chromosome.1 Among these, Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL, MIM 600142) and Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL, MIM 125310, MIM 616779) are two single-gene disorders characterized with progressive ischemic leukoencephalopathy, ...
Source: Journal of Stroke and Cerebrovascular Diseases - July 21, 2021 Category: Neurology Authors: Can Ebru Bekircan-Kurt, Arda Çetinkaya, Rahsan Gocmen, Can Koşukcu, Figen Soylemezoglu, Ethem Murat Arsava, Asli Tuncer, Sevim Erdem-Ozdamar, Nurten A. Akarsu, Mehmet Akif Topcuoglu Source Type: research
Could salt intake directly affect the cerebral microvasculature in hypertension?
Cerebral small vessel disease (CSVD) is a significant cause of stroke and dementia,1,2 as well as gait impairment and falls in the elderly.3 However, its pathophysiology is still poorly understood, and no specific treatment strategies exist.
Source: Journal of Stroke and Cerebrovascular Diseases - July 21, 2022 Category: Neurology Authors: Ana Monteiro, Pedro Castro, Gilberto Pereira, Carmen Ferreira, Cristina Duque, Farzaneh Sorond, Andrew Milstead, James P. Higgins, Jorge Pol ónia, Elsa Azevedo Source Type: research
Associations of carotid artery flow parameters with MRI markers of cerebral small vessel disease and patterns of brain atrophy
Cerebral small vessel disease (CSVD) affects small arteries, arterioles, veins and capillaries of the brain. Although a common and often silent condition occurring among healthy elderly people, it is associated with stroke, dementia, gait disturbances, cognitive decline and depression.1 –4 Magnetic resonance imaging (MRI) markers of CSVD include: white matter changes (WMC), microbleeds (MB) and lacunar infarctions (LAC).5 They can be investigated either individually or be viewed as a dynamic whole-brain disease.
Source: Journal of Stroke and Cerebrovascular Diseases - January 18, 2023 Category: Neurology Authors: Katarina Ellstr öm, Kasim Abul-Kasim, Arkadiusz Siennicki-Lantz, Sölve Elmståhl Source Type: research
A New Classification System for Ischemia Using a Combination of Deep and Periventricular White Matter Hyperintensities
In this study, we aimed to evaluate the validity of the CREDOS ischemia classification system. A total of 352 patients with cognitive impairments were included. Their WMH scores were rated using the CREDOS WMH visual rating scale. These patients were divided into 3 groups according to the CREDOS ischemia classification system. The volume of WMH was also automatically measured. The number of lacunes and microbleeds (MBs) were counted. The CREDOS ischemia classification system was revised with factor analysis using vascular risk factors and cerebrovascular disease (CVD) markers (WMH volume, lacunes, and MBs). External valida...
Source: Journal of Stroke and Cerebrovascular Diseases - July 17, 2013 Category: Neurology Authors: Young Noh, Yunhwan Lee, Sang Won Seo, Jee H. Jeong, Seong Hye Choi, Joung Hwan Back, Sook-Young Woo, Geon Ha Kim, Ji Soo Shin, Chi Hun Kim, Hanna Cho, Joon Sung Park, Jong-Min Lee, Chang Hyung Hong, Sang Yun Kim, Jae-Hong Lee, Seong Yoon Kim, Kee Hyung Pa Tags: Original Articles Source Type: research
Blood Viscosity in Subcortical Vascular Mild Cognitive Impairment with versus without Cerebral Amyloid Burden
Conclusions: Increased DBV is an important contributor to the development of “pure” svMCI (ie, without cerebral amyloid deposition). The relationship between BV and PiB(+) svMCI differed according to ApoE genotype, suggesting that the pathogenesis of PiB(+) svMCI might also be heterogeneous.
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2014 Category: Neurology Authors: Hyun J. Noh, Sang W. Seo, Yong Jeong, Jeong E. Park, Geon H. Kim, Young Noh, Hanna Cho, Hee J. Kim, Cindy W. Yoon, Byong S. Ye, David J. Werring, Duk L. Na Tags: Original Articles Source Type: research
Dual Task Walking Reveals Cognitive Dysfunction in Community-dwelling Elderly Subjects: The Sefuri Brain MRI Study
The aim of our study was to investigate the effects of subclinical brain lesions and cognitive function on gait performance with or without concurrent cognitive task in community-dwelling elderly subjects. Participants without dementia (92 men and 109 women with a mean age of 67.8 years) underwent brain magnetic resonance imaging, neuropsychologic tests, and gait measurements. Impaired gait velocity of the Timed Up and Go test was associated with deep white matter lesions (odds ratio [OR], 2.338; 95% confidence interval [CI], 1.120-4.880) and diabetes mellitus (OR, 2.725; 95% CI, 1.120-6.630) after adjusted for age, sex, ...
Source: Journal of Stroke and Cerebrovascular Diseases - June 23, 2014 Category: Neurology Authors: Manabu Hashimoto, Yuki Takashima, Akira Uchino, Takefumi Yuzuriha, Hiroshi Yao Tags: Original Articles Source Type: research
Rationale and Design of a Multicenter, Phase 2 Clinical Trial to Investigate the Efficacy of Traditional Chinese Medicine SaiLuoTong in Vascular Dementia
Vascular dementia (VaD) is the second most prevalent type of dementia among the aged, for whom limited pharmacologic options are available so far. SaiLuoTong capsule is a modern traditional Chinese medicine formula, which has been demonstrated to improve cognition of VaD by the reports of animal experiments and preliminary clinical trial. However, evaluation of this therapy in randomized multicenter trials is needed. In this article, we present the rationale and design of the SaiLuoTong in Vascular Dementia Study.
Source: Journal of Stroke and Cerebrovascular Diseases - October 4, 2014 Category: Neurology Authors: Junhua Liang, Fang Li, Cuibai Wei, Haiqing Song, Liyong Wu, Yi Tang, Jianping Jia Source Type: research
Leisure-Time Physical Inactivity Associated with Vascular Depression or Apathy in Community-Dwelling Elderly Subjects: The Sefuri Study
We examined 317 community-dwelling elderly subjects (137 men and 180 women with a mean age of 64.5 years) without dementia or clinically apparent depression.
Source: Journal of Stroke and Cerebrovascular Diseases - August 20, 2015 Category: Neurology Authors: Hiroshi Yao, Yuki Takashima, Yuko Araki, Akira Uchino, Takefumi Yuzuriha, Manabu Hashimoto Source Type: research
Beneficial Effect of Protein Tyrosine Phosphatase Inhibitor and Phytoestrogen in Dyslipidemia-Induced Vascular Dementia in Ovariectomized Rats
Estrogen deficiency and increase in protein tyrosine phosphatase (PTPase) activity may be a key mechanism in postmenopausal dyslipidemia–induced vascular dysfunction and dementia. Thus, the present study has been designed to investigate the effect of biochanin A (BCA, a phytoestrogen) and sodium orthovanadate (SOV), an inhibitor of PTPase in dyslipidemia-induced vascular dementia in ovariectomized rats.
Source: Journal of Stroke and Cerebrovascular Diseases - August 28, 2015 Category: Neurology Authors: Aditi Verma, Saurabh Sharma Source Type: research
Resveratrol Reverses the Synaptic Plasticity Deficits in a Chronic Cerebral Hypoperfusion Rat Model
Dementia is the most prevalent neurological disease in aged people. Chronic cerebral hypoperfusion (CCH) is one of the causes of vascular dementia (VaD) and is also an etiological factor for Alzheimer's disease (AD). However, effective therapy for those two diseases is still missing. Resveratrol is a polyphenol produced by plants that have multiple biological functions, such as increased life span and delay in the onset of diseases associated with aging. It is known supplement with resveratrol could exert neuroprotection against multiple injury factors induced neuronal death and degeneration, as well as the cognitive decline of CCH rat model.
Source: Journal of Stroke and Cerebrovascular Diseases - October 8, 2015 Category: Neurology Authors: Huagang Li, Jing Wang, Pu Wang, Yan Rao, Liping Chen Source Type: research
Relationship between Silent Brain Infarction and Amount of Daily Coffee Consumption in Middle Age
In aging societies such as that of Japan, it is important to characterize lifestyle-related factors that minimize the occurrence of silent brain infarction (SBI) among the middle aged population for preventing vascular dementia in older age. Little is known about the relationship between amount of coffee consumption and SBI.
Source: Journal of Stroke and Cerebrovascular Diseases - April 6, 2016 Category: Neurology Authors: Hiroshi Nakaguchi, Akira Matsuno, Toshiyuki Okubo, Katsumi Hoya Source Type: research
Neuroprotective Effects of Nicorandil in Chronic Cerebral Hypoperfusion-Induced Vascular Dementia
Ischemia-induced chronic cerebral hypoperfusion (CCH) is associated with reduced cerebral blood flow and vascular dementia (VaD). Brain mitochondrial potassium (adenosine triphosphate-sensitive potassium [KATP]) channels have a beneficial role in various brain conditions. The utility of KATP channels in CCH-induced VaD is still unknown. The aim of this study is to investigate the role of nicorandil, a selective KATP channel opener, in CCH-induced VaD.
Source: Journal of Stroke and Cerebrovascular Diseases - September 8, 2016 Category: Neurology Authors: Surbhi Gupta, Prabhat Singh, Bhupesh Sharma Source Type: research
Calcified Amorphous Tumor Causing Shower Embolism to the Brain: A Case Report with Serial Echocardiographic and Neuroradiologic Images and a Review of the Literature
An 89-year-old woman with chronic atrial fibrillation, hypertension, chronic heart failure, and dementia was admitted to our hospital due to multiple small cerebral and cerebellar infarctions. Transthoracic echocardiogram revealed a floating calcified mass lesion arising from the endocardium of the posterior portion of the mitral annulus with mitral annular calcification. Furthermore, the mass had a heterogeneity of the echogenicity. The mass was diagnosed as a calcified amorphous tumor based on specific echocardiographic features.
Source: Journal of Stroke and Cerebrovascular Diseases - March 17, 2017 Category: Neurology Authors: Takaomi Singu, Yuichiro Inatomi, Toshiro Yonehara, Yukio Ando Tags: Case Studies Source Type: research
