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Differential Impact of Index Stroke on Dementia Risk in African-Americans Compared to Whites
To compare whites and African-Americans in terms of dementia risk following index stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - August 1, 2018 Category: Neurology Authors: D.G. Clark, A.D. Boan, C. Sims-Robinson, R.J. Adams, E.J. Amella, A. Benitez, D.T. Lackland, B. Ovbiagele Source Type: research

Computer Tomography for Prediction of Cognitive Outcomes after Ischemic Cerebrovascular Events
Conclusions: CT parameters are independently associated with SCogI at 3-6 months after an ischemic cerebrovascular event and may be a clinically useful component in predicting for SCogI after stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - May 2, 2014 Category: Neurology Authors: Monica Saini, Chuen S. Tan, Saima Hilal, YanHong Dong, Eric Ting, Mohammad K. Ikram, Vijay K. Sharma, Christopher Chen Tags: Original Articles Source Type: research

Central Alveolar Hypoventilation (Ondine's Curse) Caused by Megadolichobasilar Artery
We present a case of a fatal symptomatic acquired CAH syndrome caused by megadolichobasilar artery. A 62-year-old man with pre-existing vascular dementia suffered an acute posterior stroke. During stroke care, long episodes of hypopnea and apnea were observed which responded well to verbal reminders. During an unobserved episode, the patient was found unresponsive, with chemical signs of prolonged hypoventilation not explainable by cardiopulmonary disease. A diaphragmatic pacemaker, assisted ventilation, and repeated resuscitation were refused by the patient, who died some days later. CAH is a rare complication that can oc...
Source: Journal of Stroke and Cerebrovascular Diseases - March 4, 2013 Category: Neurology Authors: Josef G. Heckmann, Stefan Ernst Tags: Case Reports Source Type: research

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Associated With a Novel In-Frame Mutation in the NOTCH3 Gene in a Japanese Patient
Here, we report a case involving a 67-year-old Japanese woman with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) associated with a novel in-frame complex rearrangement in the NOTCH3 gene. The patient had gradually developed cognitive impairment since the occurrence of an ischemic stroke at the age of 53 years. Her mother had a history of stroke and dementia. Fluid-attenuated inversion recovery magnetic resonance imaging of the brain showed hyperintense lesions in the bilateral temporal poles, external capsules, and periventricular white matter accompanied by multiple c...
Source: Journal of Stroke and Cerebrovascular Diseases - November 3, 2019 Category: Neurology Authors: Yuho Takeshi, Satoshi Suda, Takashi Shimoyama, Junya Aoki, Kentaro Suzuki, Seiji Okubo, Ikuko Mizuta, Toshiki Mizuno, Kazumi Kimura Tags: Case Report Source Type: research

Prevalence and Risk Factors of Silent Cerebral Microbleeds in Patients with Coronary Artery Disease
Coronary artery disease (CAD) and stroke are the two most common causes of death and disability worldwide, notably affecting aging populations.1 These cardiovascular disorders lead to impaired activity daily life and increase the risk of dementia.2,3 Brain magnetic resonance imaging (MRI) has excellent sensitivity in detecting ischemic lesions and can reveal asymptomatic, small, cerebral hemorrhages that are called cerebral microbleeds (CMBs).4 A systematic review reported that microbleeds were present on the MRIs of 5% of healthy adults, 34% of patients with ischemic stroke, and 60% of patients with nontraumatic intracerebral hemorrhage.
Source: Journal of Stroke and Cerebrovascular Diseases - November 22, 2021 Category: Neurology Authors: Ryo Yokoyama, Yumiko Kanzaki, Tomohiko Watanabe, Kenichiro Yamamura, Tsuyoshi Komori, Yoshihiro Takeda, Osamu Nakajima, Koichi Sohmiya, Masaaki Hoshiga Source Type: research

Looking for opportunities to co-enroll: The DISCOVERY study experience
Conducting high-quality stroke trials is complex and costly. Often these trials compete for the attention of researchers and the availability of patients. Enrolling patients in more than one study concurrently has the potential to accelerate recruitment into individual studies. DISCOVERY is a multicenter, inception cohort study of cognitive impairment and dementia following ischemic or hemorrhagic stroke. At the request of site investigators, a DISCOVERY committee reviews individual studies for approval of possible concurrent co-enrollment into DISCOVERY.
Source: Journal of Stroke and Cerebrovascular Diseases - November 1, 2022 Category: Neurology Authors: Bhrugun Anisetti, Natalia Rost, Kevin Barrett, Rebecca Gottesman, Jonathan Graff-Radford, Steven Kittner, Bernadette Boden-Albala, Heather Cissel, Brittany Mills, Kaley Carman, Prashanthi Vemuri, Lisa Wruck, Manjushri Bhapkar, Katy Donahue, Soumya Gupta, Source Type: research

Apolipoprotein Epsilon 4 Allele Modifies Waist-to-Hip Ratio Effects on Cognition and Brain Structure
Conclusions: These findings suggest that associations between central adiposity and both neuropsychological performance and underlying brain structure are highly complex and must be considered in the context of possible modifying genetic influences.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2011 Category: Neurology Authors: David Zade, Alexa Beiser, Regina McGlinchey, Rhoda Au, Sudha Seshadri, Carole Palumbo, Philip A. Wolf, Charles DeCarli, William Milberg Tags: Original Articles Source Type: research

Association of rs2075575 and rs9951307 Polymorphisms of AQP-4 Gene with Leukoaraiosis
Background: Leukoaraiosis (LA) is associated with structural and functional vascular changes that correlate with motor and gait disturbances, depressive symptoms, urinary disturbances, and dementia. The blood–brain barrier (BBB) plays a key role in development of lacunar stroke, leukoaraiosis, and other feature of cerebral small-vessel disease, and there are numerous studies examining changes in the BBB with normal aging and in dementia and LA. Aquaporin-4 (AQP-4), the primary water channel protein in the central nervous system, is involved in BBB development, function, and integrity, and its dysfunction induces several ...
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2014 Category: Neurology Authors: Binod K. Yadav, Sun-Young Oh, Nam-Keun Kim, Byoung-Soo Shin Tags: Original Articles Source Type: research

Prevalence and Clinicoradiological Analyses of Patients with Alzheimer Disease Coexisting Multiple Microbleeds
Conclusions: The present study indicated that the prevalence of multiple MBs was 17% in Japanese AD patients. The clinicoradiological profile suggested severe degree of CAA in patients with multiple L MBs (9%) and hypertension and aged changes in patients with multiple D/I MBs (8%). T2*-weighted imaging is a useful tool for evaluating degree of CAA and hypertensive vascular changes. We should pay more attention to management and care in AD patients with multiple MBs.
Source: Journal of Stroke and Cerebrovascular Diseases - August 29, 2014 Category: Neurology Authors: Junpei Nagasawa, Tetsuhito Kiyozaka, Ken Ikeda Tags: Original Articles Source Type: research

High Incidence of Dementia Conversion than Stroke Recurrence in Poststroke Patients of Late Elder Society
This study investigated the incidence of current poststroke dementia (PSD), the annual conversion ratio into PSD, and the risk factors for conversion.
Source: Journal of Stroke and Cerebrovascular Diseases - April 21, 2015 Category: Neurology Authors: Yumiko Nakano, Kentaro Deguchi, Toru Yamashita, Ryuta Morihara, Kosuke Matsuzono, Yuko Kawahara, Kota Sato, Syoichiro Kono, Nozomi Hishikawa, Yasuyuki Ohta, Yasuto Higashi, Yoshiki Takao, Koji Abe Source Type: research

An Up-to-Date Review on Cerebral Microbleeds
The objective of this study is to summarize the main risk factor, impairment, and therapy of CMBs.
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2016 Category: Neurology Authors: Yan Wu, Tao Chen Tags: Review Article Source Type: research

Is There Equipoise Regarding the Optimal Medical Treatment of Patients with Asymptomatic White Matter Hyperintensities?
Background: White matter hyperintensity (WMH) is a common manifestation of chronic ischemic microvascular disease that heralds greater risk of functional disability, stroke, and dementia. SPRINT MIND recently reported that intensive blood pressure reduction resulted in lower rates of mild cognitive impairment and WMH progression, suggesting that medical interventions could have a measurable impact on WMH. We conducted an anonymous survey of providers in the NINDS StrokeNet to better understand neurologist attitudes about asymptomatic WMH.
Source: Journal of Stroke and Cerebrovascular Diseases - September 4, 2019 Category: Neurology Authors: Adam de Havenon, Shyam Prabhakaran, Tanya Turan, Rebecca Gottesman, Sharon Yeatts, Natalia Rost Source Type: research

Impact of Race-Ethnic and Economic Disparities on Rates of Vascular Dementia in the National Inpatient Sample Database from 2006-2014
We have previously reported regional differences in the rates of vascular dementia (VD) in the United States (US), with the West having lower rates of VD diagnosis found in the Healthcare Cost and Utilization Project Nationwide Inpatient Sample (NIS) Database. We aimed to determine if these regional differences were associated with race-ethnic disparities in economic status or prevalence of the stroke risk factors hypertension, diabetes, and hyperlipidemia.
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2020 Category: Neurology Authors: Alexis Netis Simpkins Tags: Poster 10 Source Type: research

Brachial-Ankle Pulse Wave Velocity is Related to the Total Cerebral Small-Vessel Disease Score in an Apparently Healthy Asymptomatic Population
Cerebral small-vessel disease (CSVD) is an extensive cerebrovascular disease that mainly involves the perforating arterioles, capillaries and venules and plays a crucial role in stroke and dementia.1 Due to the inability of conventional noninvasive angiography to display small cerebral vessels, relevant brain parenchymal lesions on brain magnetic resonance imaging (MRI) can be used as an alternative marker for CSVD. These markers include recent small subcortical infarcts, lacunes of presumed vascular origin, white matter hyperintensity (WMH) of presumed vascular origin, perivascular space (PVS), cerebral microbleeds (CMBs)...
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Tiantian Liu, Yuanyuan Liu, Shuhua Wang, Xiaolong Du, Zhaofeng Zheng, Ning Wang, Xunyao Hou, Chao Shen, Jian Chen, Xueping Liu Source Type: research

The Association between Cerebral Small Vessel Disease and the Gut Microbiome: A Cross-Sectional Analysis
Cerebral small vessel disease (SVD) has been a research focus as a risk factor for both stroke and dementia.1 Cerebral SVD is characterised by brain magnetic resonance imaging (MRI) abnormalities, as silent lacunar infarcts (SLIs), white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), and enlarged periventricular spaces (EPVSs).1 These findings are frequently encountered in patients with vascular risk factors, and are also common in patients with early stages of cognitive impairment.
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2021 Category: Neurology Authors: Naoki Saji, Kenta Murotani, Takayoshi Hisada, Tsuyoshi Tsuduki, Taiki Sugimoto, Ai Kimura, Shumpei Niida, Kenji Toba, Takashi Sakurai Source Type: research

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