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2018 Alzheimer's disease facts and figures
This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, costs of care, and the overall impact on caregivers and society. The Special Report examines the benefits of diagnosing Alzheimer's earlier in the disease process, in the stage of mild cognitive impairment due to Alzheimer's disease. An estimated 5.7 million Americans have Alzheimer's dementia. By mid-century, the number of people living with Alzheimer's dementia in the United States is projected to grow to 13.8 million, fueled in large part by the aging baby boom generation. In 2015, o...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 20, 2018 Category: Geriatrics Source Type: research

Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study
We present VICCCS-2. Methods We used VICCCS-1 principles and published diagnostic guidelines as points of reference for an online Delphi survey aimed at achieving consensus on clinical diagnosis of VCI. Results Six survey rounds comprising 65–79 participants agreed guidelines for diagnosis of VICCCS-revised mild and major forms of VCI and endorsed the National Institute of Neurological Disorders–Canadian Stroke Network neuropsychological assessment protocols and recommendations for imaging. Discussion The VICCCS-2 suggests standardized use of the National Institute of Neurological Disorders–Canadian Stroke Network re...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 23, 2017 Category: Geriatrics Source Type: research

Association of cancer and Alzheimer's disease risk in a national cohort of veterans
Discussion Survivors of some cancers have a lower risk of AD but not other age-related conditions, arguing that lower AD diagnosis is not simply due to bias. Cancer treatment may be associated with decreased risk of AD.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 13, 2017 Category: Geriatrics Source Type: research

Population-based stroke and dementia incidence trends: Age and sex variations
This study explores these trends within demographic subgroups. Methods We analyzed administrative data sources using validated algorithms to calculate stroke and dementia incidence rates from 2002 to 2013. Results For more than 12 years, stroke incidence remained unchanged among those aged 20 to 49 years and decreased for those aged 50 to 64, 65 to 79, and 80+ years by 22.7%, 36.9%, and 37.9%, respectively. Dementia incidence increased by 17.3% and 23.5% in those aged 20 to 49 and 50 to 64 years, respectively, and remained unchanged in those aged 65 to 79 years and decreased by 15.4% in those aged 80+ years. Discussion T...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 30, 2017 Category: Geriatrics Source Type: research

2017 Alzheimer's disease facts and figures
This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, costs of care, and the overall impact on caregivers and society. The Special Report examines how the use of biomarkers may influence the AD diagnostic process and estimates of prevalence and incidence of the disease. An estimated 5.5 million Americans have Alzheimer's dementia. By mid-century, the number of people living with Alzheimer's dementia in the United States is projected to grow to 13.8 million, fueled in large part by the aging baby boom generation. Today, someone in the country develo...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 14, 2017 Category: Geriatrics Source Type: research

DNP, mitochondrial uncoupling, and neuroprotection: A Little Dab'll Do Ya
Publication date: Available online 4 September 2016 Source:Alzheimer's & Dementia Author(s): John G. Geisler, Krisztina Marosi, Joshua Halpern, Mark P. Mattson Recent findings have elucidated roles for mitochondrial uncoupling proteins (UCPs) in neuronal plasticity and resistance to metabolic and oxidative stress. UCPs are induced by bioenergetic challenges such as caloric restriction and exercise and may protect neurons against dysfunction and degeneration. The pharmacological uncoupler 2,4-dinitrophenol (DNP), which was once prescribed to >100,000 people as a treatment for obesity, stimulates several adap...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 3, 2016 Category: Geriatrics Source Type: research

METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research
Publication date: Available online 1 August 2016 Source:Alzheimer's & Dementia Author(s): METACOHORTS Consortium Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer's disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinicall...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 2, 2016 Category: Geriatrics Source Type: research

Delayed-onset dementia after stroke or transient ischemic attack
Discussion Severe SVD contributes importantly to delayed-onset dementia after stroke and/or TIA. Future clinical trials aiming to prevent delayed-onset dementia after stroke and/or TIA should target this high-risk group.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 17, 2016 Category: Geriatrics Source Type: research

2016 Alzheimer's disease facts and figures
This report describes the public health impact of Alzheimer's disease, including incidence and prevalence, mortality rates, costs of care, and the overall impact on caregivers and society. It also examines in detail the financial impact of Alzheimer's on families, including annual costs to families and the difficult decisions families must often make to pay those costs. An estimated 5.4 million Americans have Alzheimer's disease. By mid-century, the number of people living with Alzheimer's disease in the United States is projected to grow to 13.8 million, fueled in large part by the aging baby boom generation. Today, someo...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 18, 2016 Category: Geriatrics Source Type: research

Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease
Conclusions A loss-of-function mutation in ABCA1, present in 1:500 individuals, was associated with low plasma levels of apoE and with high risk of AD and cerebrovascular disease in the general population.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 30, 2015 Category: Geriatrics Source Type: research

Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline
Conclusions Atherosclerosis, in particular in the extracranial carotid arteries, is related to a higher risk of dementia and cognitive decline.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 28, 2015 Category: Geriatrics Source Type: research

Loss-of-function mutation in ABCA1 and risk of Alzheimer and cerebrovascular disease
Conclusions A loss-of-function mutation in ABCA1, present in 1:500 individuals, was associated with low plasma levels of apoE and with high risk of Alzheimer disease and cerebrovascular disease in the general population.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 28, 2015 Category: Geriatrics Source Type: research

Incidence and predictors of cognitive impairment and dementia in Aboriginal Australians: A follow-up study of 5 years
Conclusions Dementia incidence in Aboriginal Australians is among the highest in the world, and is associated with age and head injury.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 20, 2015 Category: Geriatrics Source Type: research

Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer's disease
We examined the relationships of antemortem vascular risk factors to postmortem cerebrovascular and Alzheimer's disease (AD) pathologies. Eighty-four AD patients underwent an assessment of vascular risk (blood pressure, cholesterol, smoking, cardiovascular disease, diabetes, atrial fibrillation, transient ischemic attack [TIA], or stroke) and later underwent brain autopsy. Given our aim to examine mild cerebrovascular changes (CVCs), individuals were excluded if autopsy revealed large stroke. The most common forms of CVC were circle of Willis atherosclerosis followed by arteriosclerosis, lacunes, and microinfarcts. Excludi...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 12, 2015 Category: Geriatrics Source Type: research

2015 Alzheimer's disease facts and figures
This report discusses the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, costs of care and the overall effect on caregivers and society. It also examines the challenges encountered by health care providers when disclosing an AD diagnosis to patients and caregivers. An estimated 5.3 million Americans have AD; 5.1 million are age ≥65 years, and approximately 200,000 are age <65 years and have younger onset AD. By mid-century, the number of people living with AD in the United States is projected to grow by nearly 10 million, fueled in large part by the aging ba...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 24, 2015 Category: Geriatrics Source Type: research

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