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Risk factors for incident dementia after stroke and transient ischemic attack
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 3, 2014 Category: Geriatrics Authors: Jie Yang, Adrian Wong, Zhaolu Wang, Wenyan Liu, Lisa Au, Yunyun Xiong, Winnie W.C. Chu, Eric Y.L. Leung, Sirong Chen, Christine Lau, Anne Y.Y. Chan, Alexander Y.L. Lau, Florence Fan, Vincent Ip, Yannie Soo, Thomas Leung, Chi L. Ho, Lawrence K.S. Wong, Vin Source Type: research

2014 Alzheimer's disease facts and figures
This report discusses the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, costs of care, and overall effect on caregivers and society. It also examines the impact of AD on women compared with men. An estimated 5.2 million Americans have AD. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million are age 65 years or older. By mid-century, fueled in large part by the baby boom generation, the number of people living with AD in the United States is projected to grow by about 9 million. Today, someone in the country d...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 17, 2014 Category: Geriatrics Source Type: research

2013 Alzheimer's disease facts and figures
This report provides information to increase understanding of the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, health expenditures and costs of care, and effect on caregivers and society in general. It also explores the roles and unique challenges of long-distance caregivers, as well as interventions that target those challenges. An estimated 5.2 million Americans have AD. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million comprise the older onset AD population. Throughout the coming decades, the baby boom ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 17, 2014 Category: Geriatrics Source Type: research

Development and validation of a brief dementia screening indicator for primary care
Conclusions The Dementia Screening Indicator is a simple tool that may be useful in primary care settings to identify high-risk patients to target for cognitive screening.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 19, 2014 Category: Geriatrics Source Type: research

A comparison of neuropsychological performance between US and Russia: Preparing for a global clinical trial
Conclusions Sources of variation include cultural differences, health conditions, and exposure to test stimuli. Findings highlight the importance of local norms to interpret test performance.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 19, 2014 Category: Geriatrics Source Type: research

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease
Publication date: Available online 12 December 2014 Source:Alzheimer's & Dementia Author(s): Heather M. Snyder , Roderick A. Corriveau , Suzanne Craft , James E. Faber , Steven M. Greenberg , David Knopman , Bruce T. Lamb , Thomas J. Montine , Maiken Nedergaard , Chris B. Schaffer , Julie A. Schneider , Cheryl Wellington , Donna M. Wilcock , Gregory J. Zipfel , Berislav Zlokovic , Lisa J. Bain , Francesca Bosetti , Zorina S. Galis , Walter Koroshetz , Maria C. Carrillo Scientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's diseas...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 13, 2014 Category: Geriatrics Source Type: research

Carotid plaque as a predictor of dementia in older adults: The Three-City Study
Conclusion In older adults, CP are independent predictors of incident VaD and may improve VaD risk prediction.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 13, 2014 Category: Geriatrics Source Type: research

2015 Alzheimer's disease facts and figures
This report discusses the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, costs of care and the overall effect on caregivers and society. It also examines the challenges encountered by health care providers when disclosing an AD diagnosis to patients and caregivers. An estimated 5.3 million Americans have AD; 5.1 million are age ≥65 years, and approximately 200,000 are age <65 years and have younger onset AD. By mid-century, the number of people living with AD in the United States is projected to grow by nearly 10 million, fueled in large part by the aging ba...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 24, 2015 Category: Geriatrics Source Type: research

Incidence and predictors of cognitive impairment and dementia in Aboriginal Australians: A follow-up study of 5 years
Conclusions Dementia incidence in Aboriginal Australians is among the highest in the world, and is associated with age and head injury.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 20, 2015 Category: Geriatrics Source Type: research

Loss-of-function mutation in ABCA1 and risk of Alzheimer and cerebrovascular disease
Conclusions A loss-of-function mutation in ABCA1, present in 1:500 individuals, was associated with low plasma levels of apoE and with high risk of Alzheimer disease and cerebrovascular disease in the general population.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 28, 2015 Category: Geriatrics Source Type: research

Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline
Conclusions Atherosclerosis, in particular in the extracranial carotid arteries, is related to a higher risk of dementia and cognitive decline.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 28, 2015 Category: Geriatrics Source Type: research

Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease
Conclusions A loss-of-function mutation in ABCA1, present in 1:500 individuals, was associated with low plasma levels of apoE and with high risk of AD and cerebrovascular disease in the general population.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 30, 2015 Category: Geriatrics Source Type: research

2016 Alzheimer's disease facts and figures
This report describes the public health impact of Alzheimer's disease, including incidence and prevalence, mortality rates, costs of care, and the overall impact on caregivers and society. It also examines in detail the financial impact of Alzheimer's on families, including annual costs to families and the difficult decisions families must often make to pay those costs. An estimated 5.4 million Americans have Alzheimer's disease. By mid-century, the number of people living with Alzheimer's disease in the United States is projected to grow to 13.8 million, fueled in large part by the aging baby boom generation. Today, someo...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 18, 2016 Category: Geriatrics Source Type: research

METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research
Publication date: Available online 1 August 2016 Source:Alzheimer's & Dementia Author(s): METACOHORTS Consortium Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer's disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinicall...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 2, 2016 Category: Geriatrics Source Type: research

DNP, mitochondrial uncoupling, and neuroprotection: A Little Dab'll Do Ya
Publication date: Available online 4 September 2016 Source:Alzheimer's & Dementia Author(s): John G. Geisler, Krisztina Marosi, Joshua Halpern, Mark P. Mattson Recent findings have elucidated roles for mitochondrial uncoupling proteins (UCPs) in neuronal plasticity and resistance to metabolic and oxidative stress. UCPs are induced by bioenergetic challenges such as caloric restriction and exercise and may protect neurons against dysfunction and degeneration. The pharmacological uncoupler 2,4-dinitrophenol (DNP), which was once prescribed to >100,000 people as a treatment for obesity, stimulates several adap...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 3, 2016 Category: Geriatrics Source Type: research

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