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Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association
Condition: Dementia

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Total 54 results found since Jan 2013.

Neuropsychologic assessment in collaborative Parkinson’s disease research: A proposal from the National Institute of Neurological Disorders and Stroke Morris K. Udall Centers of Excellence for Parkinson’s Disease Research at the University of Pennsylvania and the University of Washington
Abstract: Cognitive impairment (CI) and behavioral disturbances can be the earliest symptoms of Parkinson's disease (PD), ultimately afflict the vast majority of PD patients, and increase caregiver burden. Our two Morris K. Udall Centers of Excellence for Parkinson's Disease Research were supported by the National Institute of Neurological Disorders and Stroke (NINDS) in an effort to recommend a comprehensive yet practical approach to cognitive and behavioral assessment to further collaborative research. We recommend a stepwise approach with two levels of standardized evaluation to establish a common battery, as well as an...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 19, 2012 Category: Geriatrics Authors: G. Stennis Watson, Brenna A. Cholerton, Rachel G. Gross, Daniel Weintraub, Cyrus P. Zabetian, John Q. Trojanowski, Thomas J. Montine, Andrew Siderowf, James B. Leverenz Tags: Perspectives Source Type: research

Risk factors for incident dementia after stroke and transient ischemic attack
We hypothesized that chronic brain changes are important substrates for incident dementia after stroke and transient ischemic attack (TIA).
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 3, 2014 Category: Geriatrics Authors: Jie Yang, Adrian Wong, Zhaolu Wang, Wenyan Liu, Lisa Au, Yunyun Xiong, Winnie W.C. Chu, Eric Y.L. Leung, Sirong Chen, Christine Lau, Anne Y.Y. Chan, Alexander Y.L. Lau, Florence Fan, Vincent Ip, Yannie Soo, Thomas Leung, Chi L. Ho, Lawrence K.S. Wong, Vin Source Type: research

Course and etiology of dysexecutive MCI in a community sample
Conclusions: dMCI appears to follow a different course, and is less associated with Alzheimer's disease and more associated with stroke than aMCI.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 1, 2013 Category: Geriatrics Authors: Edward D. Huey, Jennifer J. Manly, Ming-X. Tang, Nicole Schupf, Adam M. Brickman, Masood Manoochehri, Jesse Mez, Charles DeCarli, Davangere P. Devanand, Richard Mayeux Tags: Featured Articles Source Type: research

Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer's disease
We examined the relationships of antemortem vascular risk factors to postmortem cerebrovascular and Alzheimer's disease (AD) pathologies. Eighty-four AD patients underwent an assessment of vascular risk (blood pressure, cholesterol, smoking, cardiovascular disease, diabetes, atrial fibrillation, transient ischemic attack [TIA], or stroke) and later underwent brain autopsy. Given our aim to examine mild cerebrovascular changes (CVCs), individuals were excluded if autopsy revealed large stroke. The most common forms of CVC were circle of Willis atherosclerosis followed by arteriosclerosis, lacunes, and microinfarcts. Excludi...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 12, 2015 Category: Geriatrics Source Type: research

Dementia: Paradigm shifting into high gear
Publication date: Available online 9 April 2019Source: Alzheimer's & DementiaAuthor(s): Vladimir HachinskiAbstractRedressing the rising threat of dementia demands not only an increase, but a diversification of efforts. We need new approaches, trials, and partners. We cannot afford to continue to only round up the usual suspects, β amyloid, and tau and try to stop them with a single drug “silver bullet”. Dementia of late onset is not a disease, but an amalgam of interactive pathologies on the shifting background of aging, requiring multimodal targeting. Cerebrovascular diseases coexist and coact with all major neurodeg...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 10, 2019 Category: Geriatrics Source Type: research

Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer's disease
We examined the relationships of antemortem vascular risk factors to postmortem cerebrovascular and Alzheimer's disease (AD) pathologies. Eighty-four AD patients underwent an assessment of vascular risk (blood pressure, cholesterol, smoking, cardiovascular disease, diabetes, atrial fibrillation, transient ischemic attack [TIA], or stroke) and later underwent brain autopsy. Given our aim to examine mild cerebrovascular changes (CVCs), individuals were excluded if autopsy revealed large stroke. The most common forms of CVC were circle of Willis atherosclerosis followed by arteriosclerosis, lacunes, and microinfarcts.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 8, 2014 Category: Geriatrics Authors: Katherine J. Bangen, Daniel A. Nation, Lisa Delano-Wood, Gali H. Weissberger, Lawrence A. Hansen, Douglas R. Galasko, David P. Salmon, Mark W. Bondi Source Type: research

Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study
We present VICCCS-2. Methods We used VICCCS-1 principles and published diagnostic guidelines as points of reference for an online Delphi survey aimed at achieving consensus on clinical diagnosis of VCI. Results Six survey rounds comprising 65–79 participants agreed guidelines for diagnosis of VICCCS-revised mild and major forms of VCI and endorsed the National Institute of Neurological Disorders–Canadian Stroke Network neuropsychological assessment protocols and recommendations for imaging. Discussion The VICCCS-2 suggests standardized use of the National Institute of Neurological Disorders–Canadian Stroke Network re...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 23, 2017 Category: Geriatrics Source Type: research

2013 Alzheimer's disease facts and figures
This report provides information to increase understanding of the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, health expenditures and costs of care, and effect on caregivers and society in general. It also explores the roles and unique challenges of long-distance caregivers, as well as interventions that target those challenges. An estimated 5.2 million Americans have AD. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million comprise the older onset AD population. Throughout the coming decades, the baby boom ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 1, 2013 Category: Geriatrics Authors: Alzheimer's Association Tags: Alzheimer's Association Report Source Type: research

Association of GWAS-linked loci with late-onset Alzheimer's disease in a northern Han Chinese population
Conclusions: This study provides the first independent evidence that MS4A and CD33 loci are associated with the risk of LOAD in northern Han Chinese population. Genotypes at the two loci confer risk predominantly in APOE ε4-negative subjects.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 10, 2012 Category: Geriatrics Authors: Lan Tan, Jin-Tai Yu, Wei Zhang, Zhong-Chen Wu, Qun Zhang, Qiu-Yan Liu, Wei Wang, Hui-Fu Wang, Xiao-Ying Ma, Wei-Zhen Cui Tags: Featured Articles Source Type: research

Revisiting the framework of the National Institute on Aging-Alzheimer's Association diagnostic criteria
Abstract: In 2011, the National Institute on Aging and the Alzheimer's Association (NIA-AA) proposed revising the criteria for diagnosing Alzheimer's disease (AD), which had been established more than 25 years earlier by the National Institute on Neurologic and Communicative Disorders and Stroke (NINCDS) and the Alzheimer's Disease and Related Disorders Association (ADRDA), now called the Alzheimer's Association. The NIA-AA initiative also built upon research criteria for AD proposed by the International Working Group (IWG) in 2007 and updated in 2010. These efforts to revise the criteria reflect the need to improve diagn...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 1, 2013 Category: Geriatrics Authors: Maria C. Carrillo, Robert A. Dean, François Nicolas, David S. Miller, Robert Berman, Zaven Khachaturian, Lisa J. Bain, Rachel Schindler, David Knopman Tags: Perspectives Source Type: research

2014 Alzheimer's disease facts and figures
This report discusses the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, costs of care, and overall effect on caregivers and society. It also examines the impact of AD on women compared with men. An estimated 5.2 million Americans have AD. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million are age 65 years or older. By mid-century, fueled in large part by the baby boom generation, the number of people living with AD in the United States is projected to grow by about 9 million. Today, someone in the country d...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 1, 2014 Category: Geriatrics Authors: Alzheimer's Association Tags: Online Exclusives Source Type: research

Midlife stroke risk and cognitive decline
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 7, 2014 Category: Geriatrics Authors: Simone Vidale Source Type: research

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