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Executive function, but not memory, associates with incident coronary heart disease and stroke
Conclusion: Lower executive function, but not memory, is associated with higher risk of coronary heart disease and stroke. Lower executive function, as an independent risk indicator, might better reflect brain vascular pathologies.
Source: Neurology - August 31, 2015 Category: Neurology Authors: Rostamian, S., van Buchem, M. A., Westendorp, R. G. J., Jukema, J. W., Mooijaart, S. P., Sabayan, B., de Craen, A. J. M. Tags: All Cerebrovascular disease/Stroke, Cardiac, Cognitive aging, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

The association of sleep apnea and stroke with cognitive performance: the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study (I9-4B)
CONCLUSIONS These results suggest that S+SA is associated with lower verbal memory and executive function scores (but not highest global cognitive impairment) than SA only, stroke only, or neither.Disclosure: Dr. Molano has nothing to disclose. Dr. Kleindorfer has received personal compensation for activities with Genentech. Dr. McClure has received research support from Genzyme and Amgen. Dr. Unverzagt has received personal compensation for activities with Eli Lilly & Company as a consultant. Dr. Wadley has received personal compensation for activities with Amgen Inc. Dr. Howard has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Molano, J., Kleindorfer, D., McClure, L., Unverzagt, F., Wadley, V., Howard, V. Tags: Treating Dementia in an Age of Mixed Disease Data Blitz Presentations Source Type: research

Subclinical cerebrovascular disease inversely associates with learning ability: The NOMAS
Conclusions: White matter hyperintensities, a marker of cerebral small vessel disease, may have an impact on learning slope. This suggests that verbal learning performance can be incorporated into neuropsychological measures for vascular cognitive impairment and that cerebrovascular disease discovered on imaging affects the ability to learn new information.
Source: Neurology - June 8, 2015 Category: Neurology Authors: Glazer, H., Dong, C., Yoshita, M., Rundek, T., Elkind, M. S. V., Sacco, R. L., DeCarli, C., Stern, Y., Wright, C. B. Tags: All Cerebrovascular disease/Stroke, Cognitive aging, Assessment of cognitive disorders/dementia ARTICLE Source Type: research

Regular aspirin use does not reduce risk of incident cognitive decline (P7.117)
CONCLUSIONS: Regular aspirin did not provide a protective association against incident cognitive impairment in a large, biracial, and geographically diverse cohort. Study Supported by: This research project is supported by a cooperative agreement U01 NS041588 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Service. Disclosure: Dr. Kelley has received personal compensation for activities with Eli Lilly & Co. as a consultant. Dr. McClure has received research support from Genzyme and Amgen. Dr. Unverzagt has received personal compensation...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kelley, B., McClure, L., Unverzagt, F., Kissela, B., Kleindorfer, D., Howard, G., Wadley, V. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Cardio- and Cerebrovascular Factors in Dementia Source Type: research

Cognitive Deficits of Large-Vessel and Small-Vessel Vascular Dementia (P6.238)
CONCLUSIONS: Patients with small-vessel VaD are more impaired than patients with large-vessel VaD in the patterns of cognitive deficits. Small-vessel VaD may contribute to cognitive decline by affecting language, visuospatial function and frontal/executive function.Study Supported by:Disclosure: Dr. Na has nothing to disclose. Dr. Yoo has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Na, J.-Y., Yoo, B.-G. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Memory Source Type: research

Leftward Where Bias And Rightward Distraction In Chronic Neglect. (P7.293)
CONCLUSIONS: We replicated previously reported, leftward Where bias in chronic neglect. Future longitudinal research can explore whether ipsilateral neglect caused rightward Aiming errors with right distraction, or whether occurs typically in contralesional neglect. N- participants demonstrated near, not far, asymmetric Aiming. Whether our findings relate to visuo-motor function instroke /neglect (e.g. fall risk) requires further study.Study Supported by: NIDRR/NIHDisclosure: Dr. Barrett has received personal compensation for activities with WebMD. Dr. Barrett has received research support from Kessler Foundation, National...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Barrett, A., Goedert, K., Oh-Park, M. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Attention/Neglect Source Type: research

Sleep duration is associated with worse neurocognitive function in Hispanic/Latinos: Results of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) (I9-4A)
CONCLUSIONS: Sleep duration had an inverted J-shaped curvilinear association with neurocognitive function, such that those with longer sleep duration had worse neurocognitive scores. Study Supported by: The Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Cent...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ramos, A., Tarraf, W., Daviglus, M., Davis, S., Gallo, L., Mossavar-Rahmani, Y., Penedo, F., Redline, S., Rundek, T., Sacco, R., Sotres-Alvarez, D., Wright, C., Zee, P., Gonzalez, H. Tags: Treating Dementia in an Age of Mixed Disease Data Blitz Presentations Source Type: research

Individualized neuro-cognitive rehabilitation can reverse cognitive and memory impairment irrespective of etiology: Prospective pilot study (P6.189)
Conclusion: Supervised neurocognitive rehabilitation, specifically designed for individual provides significant reversal of cognitive deficit in adult patients with cognitive impairment, regardless of the etiology.Disclosure: Dr. Kumar has nothing to disclose. Dr. Kumar has nothing to disclose. Dr. Jawahar has nothing to disclose. Dr. Kumar has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kumar, S., Kumar, J., Jawahar, A., Kumar, M. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Dementia: Psychosocial Aspects Source Type: research

Cognitive deficits of pure subcortical vascular dementia vs Alzheimer disease: PiB-PET-based study
Conclusions: Patients with PiB(–) SVaD were better at memory but worse at frontal function than patients with PiB(+) AD. The differences in memory/frontal functions observed between the 2 groups, however, could not differentiate all individual data due to some overlap in the cutoff threshold.
Source: Neurology - February 4, 2013 Category: Neurology Authors: Yoon, C. W., Shin, J. S., Kim, H. J., Cho, H., Noh, Y., Kim, G. H., Chin, J. H., Oh, S. J., Kim, J. S., Choe, Y. S., Lee, K.-H., Lee, J.-H., Seo, S. W., Na, D. L. Tags: All Cognitive Disorders/Dementia, Vascular dementia, Cognitive neuropsychology in dementia, Assessment of cognitive disorders/dementia ARTICLE Source Type: research

How experienced community neurologists make diagnoses during clinical encounters
We describe 3 core domains of diagnosis: 1) clinical (C), 2) laboratory and electrodiagnostics (L), and 3) neuroimaging (N). Neurologists were uniform in their practices across these domains except within the clinical domain, where the physical examination varied considerably among clinicians. All neurologists coordinated findings from the 3 domains to arrive at a final diagnosis. This practice of coordination varied across common disease categories (e.g., meningitis vs dementia). To codify this variance, we developed a provisional model of diagnostic practice derived from the data consisting of a 3-point coordinate shorth...
Source: Neurology - October 14, 2013 Category: Neurology Authors: Dhand, A., Engstrom, J., Dhaliwal, G. Tags: Cost effectiveness/economic, Decision analysis, All Clinical Neurology, Methods of education CONTEMPORARY ISSUES Source Type: research

Plasma Long Chain Fatty Acids and Cognition in Parkinson's Disease (P4.048)
CONCLUSIONS: 1) Lipid status may influence cognitive function in Parkinson's disease. 2) Principal components analysis may be a useful exploratory analysis for high-dimensional datasets like fatty acid profiles.Study Supported by:Pacific Northwest Udall Center (P50NS062684), Dept of Veteran's Affairs Northwest PADRECC, the Huber FamilyDisclosure: Dr. Murchison has received research support from National Institute for Neurological Disorders and Stroke. Dr. Quinn has received personal compensation for activities with Novartis as a speaker. Dr. Quinn has received research support from Elan Corp., Baxter Laboratories, Bristol-...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Murchison, C., Quinn, J., Cholerton, B., Leverenz, J., Montine, T., Zabetian, C., Chung, K., Peterson, A., Bowman, G. Tags: Movement Disorders: Parkinson ' s Disease Biomarkers Source Type: research

Prognostic Risk Profiles for Dementia: A Machine Learning Approach (P1.091)
Conclusions: These results suggest that vascular factors may play a greater role in dementia pathogenesis than currently thought. Furthermore, using this method we were able to achieve prediction accuracies that compare favorably with the existing literature.Disclosure: Dr. Morgenstern has nothing to disclose. Dr. Daley has nothing to disclose. Dr. Hachinski has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Morgenstern, J., Daley, M., Hachinski, V. Tags: Epidemiology of Aging and Dementias Source Type: research

CSF biomarkers suggest a strong role of glial inflammation in the pathogenesis of frontotemporal dementia (P6.104)
Conclusions:FTD features increased YKL-40, sTREM2 and NfL, a profile that distinguishes it from controls and AD. The dynamic relationship between CSF neuroinflammatory and injury biomarkers and disease severity support a strong role for neuroinflammation in the progression of FTD.Study Supported by:NIH 2T32 AG023481, National Institutes of Health, 4-Repeat Tauopathy Neuroimaging Initiative (4RTNI, AG03879); the National Center for Advancing Translational Science (NCATS) and National Institute of Neurological Disorders and Stroke (NINDS), Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL, NS09208...
Source: Neurology - April 17, 2017 Category: Neurology Authors: -Martinez, J. R., Calvet, M. S., Karydas, A., Kleinberger, G., Kramer, J., Rosen, H., Rabinovici, G., Miller, B., Fagan, A., Haass, C., Boxer, A. Tags: Aging and Dementia Poster Discussion Session: Novel Approaches in Neurodegenerative Diseases: Genetics, Biomarkers, and Therapies Source Type: research