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Risk factors for dementia in older intensive care unit (ICU) survivors
DISCUSSION: Future studies will need to examine whether interventions targeting post-ICU stroke and depression can lower dementia incidence in ICU survivors.HIGHLIGHTS: Risk factors for post-intensive care unit (ICU) dementia were distinct from those of Alzheimer's disease. Cardiovascular risk factors were not associated with dementia in older ICU survivors. Post-ICU stroke was associated with a higher risk of dementia in older ICU survivors. Post-ICU depression was associated with a higher risk of dementia in older ICU survivors.PMID:37589315 | DOI:10.1002/alz.13423
Source: The Journal of Alzheimers Association - August 17, 2023 Category: Psychiatry Authors: Sophia Wang Anthony J Perkins Rosalyn Chi Brandon A Yates Sikandar H Khan Sujuan Gao Malaz Boustani Babar A Khan Source Type: research

Prevalent stroke, age of its onset, and post-stroke lifestyle in relation to dementia: A prospective cohort study
DISCUSSION: Stroke onset in earlier life stage predicted a higher risk for dementia, but a favorable post-stroke lifestyle may protect against dementia.PMID:37157186 | DOI:10.1002/alz.13122
Source: The Journal of Alzheimers Association - May 9, 2023 Category: Psychiatry Authors: Wansi Zhong Hui Chen Xiaoxian Gong Lusha Tong Xin Xu Geng Zong Changzheng Yuan Min Lou Source Type: research

High cholesterol levels change the association of biomarkers of neurodegenerative diseases with dementia risk: Findings from a population-based cohort
This study assessed whether in a population with comorbidity of neurodegenerative and cerebrovascular disease (mixed pathology) the association of glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau181 (p-tau181) with dementia risk varied depending on levels of total cholesterol and apolipoprotein E (APOE) ε4 genotype.METHODS: Plasma biomarkers were measured using Simoa technology in 768 participants of a nested case-control study embedded within an ongoing population-based cohort. Logistic and spline regression models, and receiver operating characteristic curves were calculate...
Source: The Journal of Alzheimers Association - January 13, 2023 Category: Psychiatry Authors: Laura Perna Ute Mons Hannah Stocker L éon Beyer Konrad Beyreuther Kira Trares Bernd Holleczek Ben Sch öttker Robert Perneczky Klaus Gerwert Hermann Brenner Source Type: research

Prevalence of neuropsychiatric conditions and cognitive impairment in two parallel, aging study cohorts from rural and urban India
DISCUSSION: Longitudinal assessment of these neuropsychiatric conditions, with parallel cognitive monitoring, will help identify their causal relationship with dementia.PMID:36573020 | DOI:10.1002/alz.12741
Source: The Journal of Alzheimers Association - December 27, 2022 Category: Psychiatry Authors: Jonas S Sundarakumar Abhishek L Menesgere Shubham Jain Shafeeq K S Hameed SANSCOG & TLSA Study Teams Vijayalakshmi Ravindranath Source Type: research

Multimorbidity burden and developmental trajectory in relation to later-life dementia: A prospective study
CONCLUSIONS: Both multimorbidity burden and its developmental trajectory were prospectively associated with risk of dementia.PMID:36427050 | DOI:10.1002/alz.12840
Source: The Journal of Alzheimers Association - November 25, 2022 Category: Psychiatry Authors: Hui Chen Yaguan Zhou Liyan Huang Xiaolin Xu Changzheng Yuan Source Type: research

Global, regional, and national trends of dementia incidence and risk factors, 1990-2019: A Global Burden of Disease study
CONCLUSION: The declining incidence of dementia in some countries, despite growing prevalence, is encouraging and urges further investigation.PMID:36044376 | DOI:10.1002/alz.12764
Source: The Journal of Alzheimers Association - August 31, 2022 Category: Psychiatry Authors: Abolfazl Avan Vladimir Hachinski Source Type: research

White matter hyperintensities and longitudinal cognitive decline in cognitively normal populations and across diagnostic categories: A meta-analysis, systematic review, and recommendations for future study harmonization
DISCUSSION: Recommendations and future directions for study of WMHs are provided to improve cross-study comparison and translation of research into consistent clinical interpretation.PMID:35319162 | DOI:10.1002/alz.12642
Source: The Journal of Alzheimers Association - March 23, 2022 Category: Psychiatry Authors: Austyn D Roseborough Lorenzo Saad Maren Goodman Lauren E Cipriano Vladimir C Hachinski Shawn N Whitehead Source Type: research

Tube feeding in patients with dementia is associated with a longer palliative care unit stay
CONCLUSION: The present study showed that, in patients with an established diagnosis of dementia, TF is common and independently associated with a longer length of PCU stay. Nevertheless, the study was underpowered and the results deserve confirmation in larger studies.PMID:34971282 | DOI:10.1002/alz.052919
Source: The Journal of Alzheimers Association - December 31, 2021 Category: Psychiatry Authors: Hilal Zengin Ilker Tasci Source Type: research

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