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Association of age with 1-year outcome in patients with acute ischaemic stroke treated with thrombectomy: real-world analysis in 18 506 patients
Conclusions In this large ‘real-world’ cohort, outcomes after mechanical thrombectomy were strongly associated with age. Of patients aged ≥80 years more than half were dead and less than one-fifth were functionally independent at 1 year. Certain comorbidities and ventilation >48 hours were associated with even worse outcomes.
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 13, 2023 Category: Neurosurgery Authors: Beuker, C., Köppe, J., Feld, J., Meyer, C. L., Dröge, P., Ruhnke, T., Günster, C., Wiendl, H., Reinecke, H., Minnerup, J. Tags: Open access Cerebrovascular disease Source Type: research

Role of small acute hyperintense lesions in long-term progression of cerebral small vessel disease and clinical outcome: a 14-year follow-up study
Conclusion Presence of a DWI+lesion in patients with SVD is associated with greater radiological progression of SVD and cognitive decline compared with patients without DWI+lesions.
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 11, 2023 Category: Neurosurgery Authors: Verburgt, E., Janssen, E., Jacob, M. A., Cai, M., ter Telgte, A., Wiegertjes, K., Kessels, R. P. C., Norris, D. G., Marques, J., Duering, M., Tuladhar, A. M., De Leeuw, F.-E. Tags: Cerebrovascular disease Source Type: research

198 Should we thrombolyse cognitively impaired patients with acute ischaemic stroke?
Conclusion Confounding variables were the main predictors of poorer thrombolysis outcomes in cogni- tively impaired stroke patients. A large portion of these poorer outcomes remains unexplained, leaving potential for further investigation.
Source: Journal of Neurology, Neurosurgery and Psychiatry - August 12, 2022 Category: Neurosurgery Authors: Ramnarine, I., Rasheed, O., Harkness, K., Majid, A., Bell, S. Tags: Poster presentations Source Type: research

050 Feasibility of an automated assessment to measure cognition and mood in the acute stroke setting
Discussion Screening was adapted due to Covid pandemic and utilising remote consent and participa- tion allowed the project to continue.
Source: Journal of Neurology, Neurosurgery and Psychiatry - August 12, 2022 Category: Neurosurgery Authors: Bell, S., Harkness, K., Roman, M., Gardner, J., Richards, E., Howe, J., Sikaonga, M., Mirheidari, B., Christensen, H., Blackburn, D. Tags: Poster presentations Source Type: research

Late-onset epilepsy predicts future stroke: a systematic review and meta-analysis
Late-onset epilepsy (LOE) is closely associated with cerebrovascular disease. LOE also appears to be a harbinger of dementia. We performed a systematic review of observational studies, clinical studies and radiological studies relating to LOE. We conducted a meta-analysis of 5 observational studies and have found that patients presenting with LOE experience an increased risk of subsequent stroke, weighted OR 3.88 (95% CI 2.76 - 5.46). Above the age of fifty, incidence of new onset epilepsy is approximately 400/100,000 person years. Of these, 9.8–11.9% will have a stroke in the decade following epilepsy onset, transla...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Wall, J., Knight, J., Emsley, H. Tags: Parallel Session 3: Prognosis, Speaker 3 Source Type: research

Prevalence of dementia in ischaemic or mixed stroke populations: systematic review and meta-analysis
An understanding of the epidemiology of poststroke dementia (PSD) is necessary to inform research, practice and policy. With increasing primary studies, a contemporary review of PSD could allow for analyses of incidence and prevalence trends. Databases were searched using a prespecified search strategy. Eligible studies described an ischaemic or mixed stroke cohort with prospective clinical assessment for dementia. Pooled prevalence of dementia was calculated using random-effects models at any time after stroke (primary outcome) and at 1 year (range: 6–18 months), stratified for inclusion of prestroke dementia. Meta-...
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 17, 2022 Category: Neurosurgery Authors: Craig, L., Hoo, Z. L., Yan, T. Z., Wardlaw, J., Quinn, T. J. Tags: Open access, Editor's choice Neurodegeneration Source Type: research

Brain volume loss precedes cognitive decline in the first year after ischaemic stroke
Conclusions Brain volume loss precedes cognitive decline in the first year after ischaemic stroke. Tracking brain volume after stroke is important because brain volume is predictive of cognitive decline and atrophy is a hallmark of dementia.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 8, 2017 Category: Neurosurgery Authors: Werden, E., Cumming, T., Bird, L., Khlif, M., Brodtmann, A. Tags: Abstracts Source Type: research

Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease: ICICLE-PD study
Conclusions Reductions in cortical FDG metabolism were present in newly diagnosed PD, and correlated with performance on neuropsychological tests. A reduced baseline parietal metabolism is associated with risk of cognitive decline and may represent a potential biomarker for this state and the development of PD dementia.
Source: Journal of Neurology, Neurosurgery and Psychiatry - March 16, 2017 Category: Neurosurgery Authors: Firbank, M. J., Yarnall, A. J., Lawson, R. A., Duncan, G. W., Khoo, T. K., Petrides, G. S., O'Brien, J. T., Barker, R. A., Maxwell, R. J., Brooks, D. J., Burn, D. J. Tags: Open access, Brain stem / cerebellum, Dementia, Drugs: CNS (not psychiatric), Parkinson's disease, Stroke, Memory disorders (psychiatry), Radiology, Radiology (diagnostics) Movement disorders Source Type: research

Peg tube insertion in neurodegenerative disease
Conclusion This study highlights the relatively high risk of PEG tube placement in patients with neurodegenerative disease. We present a number of points for consideration with the aim of improving the outcome in this particularly vulnerable group of patients.
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Sarkar, P., Cole, A., Scolding, N., Rice, C. Tags: Dementia, Drugs: CNS (not psychiatric), Stroke, Memory disorders (psychiatry) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Using asl mri to characterise decline in cerebral blood flow in cadasil
Conclusion CBF in CADASIL patients declines faster than is reported for healthy individuals. This is the first study to show ASL is a feasible method to study CBF in CADASIL and has demonstrated changes over the time period which may be suitable for a clinical trial.
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Moreton, F., Gonzalez, M.-R. L., Muir, K. Tags: Dementia, Stroke, Memory disorders (psychiatry) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Randomised, waiting list controlled trial of cognitive-behavioural therapy for persistent postconcussional symptoms after predominantly mild-moderate traumatic brain injury
Conclusions This study suggests that CBT can improve quality of life for adults with persistent PCS and potentially reduce symptoms for some, in the context of outpatient brain injury rehabilitation services. Trial registration number ISRCTN49540320.
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 12, 2016 Category: Neurosurgery Authors: Potter, S. D. S., Brown, R. G., Fleminger, S. Tags: Dementia, Neurological injury, Stroke, Trauma CNS / PNS, Anxiety disorders (including OCD and PTSD), Memory disorders (psychiatry), Trauma, Injury Neuropsychiatry Source Type: research

Candidate-gene analysis of white matter hyperintensities on neuroimaging
Conclusions There is a genetic basis to WMH but anonymous genome wide and exome studies are more likely to provide novel loci of interest.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 14, 2016 Category: Neurosurgery Authors: Tran, T., Cotlarciuc, I., Yadav, S., Hasan, N., Bentley, P., Levi, C., Worrall, B. B., Meschia, J. F., Rost, N., Sharma, P. Tags: Open access, Genetics, Dementia, Stroke, Memory disorders (psychiatry) Cerebrovascular disease Source Type: research

Amyloid-related imaging abnormalities-haemosiderin (ARIA-H) in patients with Alzheimer's disease treated with bapineuzumab: a historical, prospective secondary analysis
Conclusions ARIA-H represents a spectrum of MRI findings due to haemosiderin deposition that appears to be related to impaired vascular integrity. The increased risk for ARIA-H associated with APOE 4 allele frequency, pre-existing ARIA-H, treatment with bapineuzumab and use of antithrombotic agents provides additional support for this hypothesis of loss of integrity of cerebral vessels due to amyloid burden. Trial registration NCT00112073 and NCT00606476.
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 17, 2015 Category: Neurosurgery Authors: Arrighi, H. M., Barakos, J., Barkhof, F., Tampieri, D., Jack, C., Melancon, D., Morris, K., Ketter, N., Liu, E., Brashear, H. R. Tags: Open access, Genetics, Immunology (including allergy), Dementia, Drugs: CNS (not psychiatric), Stroke, Memory disorders (psychiatry), Psychiatry of old age, Drugs: musculoskeletal and joint diseases General neurology Source Type: research

Cadasil in northern ireland: a retrospective clinical, neuroimaging and genetic study
This study demonstrates the wide variability in the phenotype and MRI features of CADASIL.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2015 Category: Neurosurgery Authors: McMacken, G., McKenna, E., McKee, S., McConville, J. Tags: Dementia, Epilepsy and seizures, Headache (including migraine), Stroke, Memory disorders (psychiatry) Wed 20, Parallel session 4: Disease pathophysiology Source Type: research

Next generation sequencing in familial cerebral small vessel disease - an ongoing study
Cerebral small vessel disease (SVD) is the most common form of stroke and vascular dementia. CADASIL (notch3 mutations) is most frequent but other monogenic causes more recently identified include CARASIL (HTRA1 gene), RVCL (TREX1 gene) and COL4A1 and 2. Diagnostic tests for these are often inaccessible and expensive and there are families with clinical monogenic SVD in whom no known variants are detected. Next generation sequencing offers the potential to screen for these diseases, which present with similar phenotypes, more cost-effectively and rapidly in a single test. It could also identify novel genes underlying SVD. ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2015 Category: Neurosurgery Authors: Tan, R., Markus, H. Tags: Dementia, Stroke, Memory disorders (psychiatry) Thur 21, Parallel session 5: Therapeutics Source Type: research

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