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Ischemic Stroke as the Presenting Symptom in a Young Patient with Essential Thrombocythemia Caused by CALR Gene Mutation (P2.253)
CONCLUSIONS: Ischemic stroke is a rare complication of essential thrombocythemia and this case is unusual because of multiple strokes in a very young patient as the presenting symptom. Fortunately, the condition was recognized and successfully treated with aspirin and hydroxyurea. She was not left with any residual neurological deficits. This case demonstrates another unusual and rarely reported cause for stroke in a young patient.Disclosure: Dr. Anderson has nothing to disclose. Dr. Bonsell has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Anderson, N., Bonsell, K. Tags: Cerebrovascular Disease and Interventional Neurology: Genetics and Stroke Source Type: research

Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome.
CONCLUSIONS: The evidence identified indicates that NOACs compared with standard-dose VKAs may increase the risk of stroke and do not appear to alter the risk of other outcomes (moderate-certainty evidence). Using high-dose VKA versus standard-dose VKA did not alter the risk of any thromboembolic event or major bleeding but may increase the risk of any form of bleeding (low-certainty evidence). Standard-dose VKA combined with an AP agent compared with standard-dose VKA alone may increase the risk of any thromboembolic event and does not appear to alter the risk of major bleeding or other outcomes (low-certainty evidence). ...
Source: Cochrane Database of Systematic Reviews - October 12, 2020 Category: General Medicine Authors: Bala MM, Celinska-Lowenhoff M, Szot W, Padjas A, Kaczmarczyk M, Swierz MJ, Undas A Tags: Cochrane Database Syst Rev Source Type: research

Stroke Due To Extracranial Internal Carotid Artery Dissection After Roller Coaster Rides In A 4-Year-Old Boy (P7.343)
CONCLUSIONS: To our knowledge this is the youngest patient with stroke secondary to ICA dissection following roller-coaster rides. Although the exact mechanism of injury leading to ICA dissection in the setting of sudden linear acceleration, deceleration and rotational forces such as those experienced while riding a roller coaster is not fully understood, these injuries have been attributed to brief sustained excessive gravitational forces likely augmented among predisposed individuals. Children may be at higher risk due to the immature anatomy of their cervical spine. Alterations to roller coaster ride dynamics and use of...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Nouh, A., Vela-Duarte, D., Grobelny, T., Hoganson, G., Pasquale, D., Biller, J. Tags: Child Neurology and Developmental Neurology VI Source Type: research

Intracranial Fibromuscular Dysplasia in a Middle-Aged Woman with Recurrent Ischemic Stroke (P4.388)
Conclusions: FMD is a rare disease and has very rarely been described in the intracranial arteries. This case illustrates the natural history and progression of FMD in this patient and elucidates the limited treatment options for preventing disease progression and secondary complications. FMD most predominantly affects younger to middle-aged females and if the disease process goes unrecognized it can have devastating consequences. It is important to continue research endeavors into the genetic and biologic determinants of FMD in order to develop better prevention and therapeutic strategies for this condition.Disclosure: Dr...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Beaton, N., Malik, A., Maque-Acosta, Y., Koch, S. Tags: Non-Atherosclerotic Arteriopathies Source Type: research

Janssen to Present the Strength and Promise of its Hematologic Malignancies Portfolio and Pipeline at ASH 2021
RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.“We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline during ASH...
Source: Johnson and Johnson - November 5, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Carrie Fisher's Death Highlights The Reality Of Heart Disease In Women
Carrie Fisher died early Tuesday morning, four days after suffering a heart attack on a flight from London to Los Angeles. The actress and author, best known for her iconic role as Princess Leia in the “Star Wars” franchise, was 60 years old.  Experts say that Fisher’s death highlights an important reality about heart disease: It is the leading cause of death among men and women alike in the U.S. While heart disease encompasses many different conditions, a heart attack occurs when coronary arteries become blocked and oxygenated blood can’t reach the heart. About 735,000 Americans have hea...
Source: Science - The Huffington Post - December 28, 2016 Category: Science Source Type: news

Clinical Reasoning: Acute onset facial droop in a 36-year-old pregnant woman
A 36-year-old woman, G1P0, 22 weeks pregnant, presented to the emergency department for evaluation of acute onset facial droop. Her medical history included ulcerative colitis, primary sclerosing cholangitis, and heterozygosity for the prothrombin G20210A mutation. She was on 10,000 units of subcutaneous heparin twice daily for a previous deep vein thrombosis secondary to her prothrombin mutation; she was noncompliant with prescribed aspirin.
Source: Neurology - June 12, 2017 Category: Neurology Authors: George, I. C., Youn, T. S., Marcolini, E. G., Greer, D. M. Tags: Other cerebrovascular disease/ Stroke, Autoimmune diseases, Critical care, All Demyelinating disease (CNS) RESIDENT AND FELLOW SECTION Source Type: research