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Soluble FAS Ligand Enhances Suboptimal CD40L/IL-21-Mediated Human Memory B Cell Differentiation into Antibody-Secreting Cells
J Immunol. 2021 Jul 2:ji2001390. doi: 10.4049/jimmunol.2001390. Online ahead of print.ABSTRACTDifferentiation of Ag-specific B cells into class-switched, high-affinity, Ab-secreting cells provides protection against invading pathogens but is undesired when Abs target self-tissues in autoimmunity, beneficial non-self-blood transfusion products, or therapeutic proteins. Essential T cell factors have been uncovered that regulate T cell-dependent B cell differentiation. We performed a screen using a secreted protein library to identify novel factors that promote this process and may be used to combat undesired Ab formation. We...
Source: Journal of Immunology - July 3, 2021 Category: Allergy & Immunology Authors: Saskia D van Asten Peter-Paul Unger Casper Marsman Sophie Bliss Tineke Jorritsma Nicole M Thielens S Marieke van Ham Robbert M Spaapen Source Type: research

Medical History, Lifestyle, Family History, and Occupational Risk Factors for Follicular Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Conclusions The few relationships observed provide clues suggesting a multifactorial etiology of FL but are limited in the extent to which they explain FL occurrence.
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Linet, M. S., Vajdic, C. M., Morton, L. M., de Roos, A. J., Skibola, C. F., Boffetta, P., Cerhan, J. R., Flowers, C. R., de Sanjose, S., Monnereau, A., Cocco, P., Kelly, J. L., Smith, A. G., Weisenburger, D. D., Clarke, C. A., Blair, A., Bernstein, L., Zh Tags: Article Source Type: research

Etiologic Heterogeneity Among Non-Hodgkin Lymphoma Subtypes: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Conclusions Using a novel approach to investigate etiologic heterogeneity among NHL subtypes, we identified risk factors that were common among subtypes as well as risk factors that appeared to be distinct among individual or a few subtypes, suggesting both subtype-specific and shared underlying mechanisms. Further research is needed to test putative mechanisms, investigate other risk factors (eg, other infections, environmental exposures, and diet), and evaluate potential joint effects with genetic susceptibility.
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Morton, L. M., Slager, S. L., Cerhan, J. R., Wang, S. S., Vajdic, C. M., Skibola, C. F., Bracci, P. M., de Sanjose, S., Smedby, K. E., Chiu, B. C. H., Zhang, Y., Mbulaiteye, S. M., Monnereau, A., Turner, J. J., Clavel, J., Adami, H.-O., Chang, E. T., Glim Tags: Article Source Type: research