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Source: Journal of Allergy and Clinical Immunology
Condition: Autoimmune Disease

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Total 204 results found since Jan 2013.

RelB-deficient autoinflammatory pathology presents as interferonopathy, but in mice is IFN-independent
Autoimmune diseases are leading causes of ill health and morbidity and have diverse etiology. Two signaling pathways are key drivers of autoimmune pathology, interferon and NF κB/RelA, defining the two broad labels of interferonopathies and relopathies. Prior work established that genetic loss of function of the NFκB subunit RelB leads to autoimmune and inflammatory pathology in mice and humans.
Source: Journal of Allergy and Clinical Immunology - July 14, 2023 Category: Allergy & Immunology Authors: Hector I. Navarro, Yi Liu, Anna Fraser, Diane Lefaudeux, Jennifer J. Chia, Linda Vong, Chaim M. Roifman, Alexander Hoffmann Source Type: research

RelB-deficient autoinflammatory pathology presents as interferonopathy, but in mice is interferon-independent
Autoimmune diseases are leading causes of ill health and morbidity and have diverse etiology. Two signaling pathways are key drivers of autoimmune pathology, interferon and nuclear factor- κB (NF-κB)/RelA, defining the 2 broad labels of interferonopathies and relopathies. Prior work has established that genetic loss of function of the NF-κB subunit RelB leads to autoimmune and inflammatory pathology in mice and humans.
Source: Journal of Allergy and Clinical Immunology - July 14, 2023 Category: Allergy & Immunology Authors: H éctor I. Navarro, Yi Liu, Anna Fraser, Diane Lefaudeux, Jennifer J. Chia, Linda Vong, Chaim M. Roifman, Alexander Hoffmann Source Type: research

Activated Phosphoinositide 3-Kinase δ Syndrome: Update from the ESID Registry and comparison with other autoimmune-lymphoproliferative inborn errors of immunity
When comparing the phenotypic overlap of autoimmune-lymphoproliferative inborn errors of immunity (IEI) APDS demonstrates high penetrance, low genetic heterogeneity, early-onset as risk factor for severe disease and high phenotypic overlap with other IEIs.
Source: Journal of Allergy and Clinical Immunology - June 27, 2023 Category: Allergy & Immunology Authors: Maria Elena Maccari, Martin Wolkewitz, Charlotte Schwab, Tiziana Lorenzini, Jennifer W. Leiding, Nathalie Aladjdi, Hassan Abolhassani, Wadih Abou-Chahla, Alessandro Aiuti, Saba Azarnoush, Safa Baris, Vincent Barlogis, Federica Barzaghi, Ulrich Baumann, Ma Source Type: research

Autoimmune manifestations in VEXAS: Opportunities for integration and pitfalls to interpretation
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a novel entity manifesting with a multiplicity of clinical features. Somatic mutations of the UBA1 gene in hematopoietic stem cells constitute the genetic basis of VEXAS. As an X-linked disorder, most cases occur in men, classically developing symptoms during the fifth to sixth decade of life. Considering its multidisciplinary nature involving numerous branches of internal medicine, VEXAS has elicited a wide medical interest and several medical conditions have been associated with this disease.
Source: Journal of Allergy and Clinical Immunology - March 20, 2023 Category: Allergy & Immunology Authors: Alessandro Bruno, Carmelo Gurnari, Tobias Alexander, John A. Snowden, Raffaella Greco, Autoimmune Diseases Working Party of the European Society for Blood and Marrow Transplantation Source Type: research

Distinct dynamics of antigen-specific induction and differentiation of different CD11c+ Tbet+ B cell subsets
CD11c+ B cells actively participate in humoral immune responses, and their phenotypic and functional diversity needs to be considered when studying these cells in the context of immune challenge in healthy individuals and autoimmune diseases.
Source: Journal of Allergy and Clinical Immunology - February 27, 2023 Category: Allergy & Immunology Authors: Juulke Steuten, Am élie V. Bos, Lisan H. Kuijper, Mathieu Claireaux, Wouter Olijhoek, George Elias, Mariel C. Duurland, Tineke Jorritsma, Casper Marsman, Alberta G.A. Paul, Juan J. Garcia Vallejo, Marit J. van Gils, Luuk Wieske, Taco W. Kuijpers, Filip E Source Type: research

Manifestations of Covid-19-associated ANCA-vasculitis
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are systemic autoimmune diseases that may lead to multi-organ failure due to the destruction of small- and medium-sized blood vessels. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may exacerbate autoimmune diseases and induced vasculitis.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Khrystyna Lishchuk-Yakymovych, Iryna Vozniak, Roman Pukalyak, Omelyan Synenkyy, Lawrence DuBuske, Valentyna Chopyak Source Type: research

Geocoding and algorithmic approach to identify biological family members of patients with celiac disease in electronic health records
It is known that people with a family history of autoimmune disease such as celiac disease (CD) are at higher risk of developing it but identifying family history in electronic health records (EHRs) can be often challenging as it is not routinely asked.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Young Juhn, Chung-Il Wi, Imad Absah, Rok Seon Choung, Robert Goodson, Joshua Bublitz, Katherine King, Euijung Ryu, Isabella Zaniletti, Joseph Murray Source Type: research

Subacute Onset of Chronic Urticaria Post COVID-19 Vaccination
Urticaria has been known to be triggered for a variety of allergy and non-allergic etiologies. Autoimmune disease, infection, and immunizations can be considered as possible underlying differentials for non-allergic urticarial eruption. I hypothesized that a subacute onset of chronic urticarial eruptions and/or demographic state was also possibly attributable to COVID-19 vaccinations in select patients observed at a single allergy and immunology practice.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Kristy Semenza Source Type: research

Allergic Outcomes at 2 years in children born during COVID-19 lockdown: the CORAL study
The CORAL study is a longitudinal study of the impact of the Coronavirus pandemic on Allergic and autoimmune dysregulation of infants born in Ireland during the first SARS-2-CoV lockdown. We hypothesised the altered environment may have consequences for microbiome colonisation, and resultantly allergic disease.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Sadhbh Hurley, Ruth Franklin, Naomi McCallion, John Fitzsimons, Aideen Byrne, Martin White, Liam O'Mahony, Jonathan Hourihane Source Type: research

Cytokine Dysregulation in Alopecia Areata Associated with Atopy
Alopecia areata (AA) is a common autoimmune disease, causing patchy hair loss that can progress to involve the entire scalp (totalis) or body (universalis). Alopecia areata co- morbidities include atopic diseases with a high association approaching 25%. The specific immune mechanisms driving hair loss and association of AA and atopy may be related to specific systemic production of cytokines which was investigated in this study of patients with and without atopy.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Galina Tereshenko, Nikolay Potekaev, Aida Gadzhigoroeva, Olga Zhukova, Roman Khanferyan, Lawrence DuBuske Source Type: research

sCD14 and Intestinal Fatty Acid Binding Protein are Elevated in the Serum of Patients with Idiopathic Anaphylaxis.
Intestinal epithelial integrity compromise has been identified in gastrointestinal (GI), atopic, and autoimmune diseases. Episodes of idiopathic anaphylaxis (IA) are often accompanied by GI manifestations. We therefore sought to determine whether surrogate markers of GI permeability were aberrant in this patient population.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Hirsh Komarow Source Type: research

Differences in IgG autoantibody Fab glycosylation across autoimmune diseases
By analyzing 10 autoantibody responses in 8 autoimmune disorders, we demonstrate that elevated Fab glycosylation is a frequent feature of autoantibodies, associated with chronic but not acute B cell-mediated autoimmune diseases.
Source: Journal of Allergy and Clinical Immunology - January 27, 2023 Category: Allergy & Immunology Authors: Jana Koers, Rocco Sciarrillo, Ninotska I.L. Derksen, Esther M. Vletter, Yvonne E. Filli é-Grijpma, Elisabeth Raveling-Eelsing, Nuno A.G. Graça, Thiemo Leijser, Hendri H. Pas, L. Laura van Nijen-Vos, Maaike V.J. Braham, Anne-Marie Buisman, Jan de Jong, A Source Type: research

Contribution of Genetic Variants associated with Primary Immunodeficiencies to Childhood-Onset Systemic Lupus Erythematous
A dysregulated immune response is a hallmark of autoimmune disorders. Evidence suggests that systemic autoimmune diseases and primary immunodeficiency disorders (PID) may be similar diseases with different clinical phenotypes.
Source: Journal of Allergy and Clinical Immunology - December 28, 2022 Category: Allergy & Immunology Authors: Chao-Yi Wu, Wen-Lang Fan, Huang-Yu Yang, Pi-Shuang Chu, Pei-Chun Liao, Li-Chen Chen, Tsung-Chieh Yao, Kuo-Wei Yeh, Liang-Shiou Ou, Syh-Jae Lin, Wen-I Lee, Jing-Long Huang Source Type: research

Comprehensive overview of autoantibody isotype and subclass distribution
The presence of autoreactive antibodies is a hallmark of many autoimmune diseases. The effector functions of (auto)antibodies are determined by their constant domain, which defines the antibody isotype and subclass. The most prevalent isotype in serum is IgG, which is often the only isotype used in diagnostic testing. Nevertheless, autoantibody responses can have their own unique isotype/subclass profile. Because comparing autoantibody isotype profiles may yield new insights into disease pathophysiology, here we summarize the isotype/subclass profiles of the most prominent autoantibodies.
Source: Journal of Allergy and Clinical Immunology - November 1, 2022 Category: Allergy & Immunology Authors: Mikhail Volkov, Mariateresa Coppola, Ruth Huizinga, Filip Eftimov, Tom W.J. Huizinga, Anneke J. van der Kooi, Liesbeth E.M. Oosten, Joost Raaphorst, Theo Rispens, Rocco Sciarrillo, Maarten J. Titulaer, Luuk Wieske, Ren é E.M. Toes, Maartje G.M. Huijbers, Tags: Review article Source Type: research

From thymus to tissues and tumors: a review of T cell biology
T cells are critical orchestrators of the adaptive immune response that optimally eliminates a specific pathogen. Aberrant T cell development and function are implicated in a broad range of human disease including immunodeficiencies, autoimmune diseases, and allergic diseases. Accordingly, therapies targeting T cells and their effector cytokines have drastically improved the care of patients with immune dysregulatory diseases. Newer discoveries concerning T cell mediated antitumor immunity and T cell exhaustion have further prompted development of highly effective and novel treatment modalities for malignancies, including ...
Source: Journal of Allergy and Clinical Immunology - October 19, 2022 Category: Allergy & Immunology Authors: Laura Chopp, Christopher Redmond, John J. O ’Shea, Daniella M. Schwartz Source Type: research