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Predicting the Outcomes of Acute Ischemic Stroke with Rheumatic Heart Disease: The Values of CHADS2, CHA2DS2–VASc, and HAS-BLED Scores
The CHADS2 and CHA2DS2–VASc score were used to evaluate the atrial fibrillation-related risk of stroke, and HAS-BLED score was used to estimate the oral anticoagulation-bleeding risk. We investigated the relationships between these 3 scores and the outcomes of acute ischemic stroke (AIS) patients with rheumatic heart disease (RHD) at 3 months after stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 8, 2016 Category: Neurology Authors: Junfeng Liu, Deren Wang, Ge Tan, Ruozhen Yuan, Mangmang Xu, Yao Xiong, Ming Liu Source Type: research

Thrombolysis in Ischemic Stroke Patients with Isolate Pulmonary Arteriovenous Malformations
Pulmonary arteriovenous malformations are rare cause for ischemic stroke. British Thoracic Society Clinical Statement considered insufficient evidence of safety or clinical benefit to recommend thrombolysis for stroke with pulmonary arteriovenous malformations. For pulmonary arteriovenous malformations with hereditary hemorrhagic telangiectasia, bleeding risk after thrombolysis is high, while for isolate pulmonary arteriovenous malformations, bleeding risk is much lower. We here present 2 cases of ischemic stroke with isolate pulmonary arteriovenous malformations treated with thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2019 Category: Neurology Authors: Gaoping Lin, Peng Jiang, Min Lou Tags: Case Report Source Type: research

Risk of Early Bleeding with Dual Antiplatelet Therapy in Acute Stroke and Transient Ischemic Attack Regardless of NIHSS Admission
Background: Dual antiplatelet therapy (DAT) is a therapeutic option for patients with minor ischemic stroke (IS) or transient ischemic attack (TIA). No study has evaluated the incidence of early bleeding in patients with moderate to major ischemic stroke. The current study aimed to analyze both the frequency of early bleeding and hospital morbidity related to DAT for either acute IS or TIA regardless of admission National Institute of Health Stroke Scale (NIHSS) score. Methods: This was a retrospective analysis based on data collected from a prospective data bank of a single center.
Source: Journal of Stroke and Cerebrovascular Diseases - March 4, 2021 Category: Neurology Authors: Valeria Cristina Scavasine, Rubens Mendes Barbosa, Francisco Diego Negrao Lopes Neto, Francisco Manoel Branco Germininani, Rodrigo Bazan, Viviane Flumignan Z étola, Ayrton Roberto Massaro, Marcos Christiano Lange Source Type: research

Anticoagulation Protocol for Secondary Prevention of Acute Ischemic Stroke Associated with Nonvalvular Atrial Fibrillation
Atrial fibrillation (AF) is a major risk factor for ischemic stroke and despite evidence for the efficacy of anticoagulation for secondary prevention of recurrent stroke in patients with AF,1 to date there is no established evidence regarding the timing for initiation of oral anticoagulants (OACs), including direct oral anticoagulants (DOACs), for secondary prevention of acute ischemic stroke associated with AF. Of concern in early initiation of OACs is the risk of recurrence balanced with the risk of hemorrhagic transformation (HT) after vascular reperfusion with reports of 3.6% symptomatic cerebral bleeding for acute use of OACs.
Source: Journal of Stroke and Cerebrovascular Diseases - June 6, 2021 Category: Neurology Authors: Teruo Kimura, Adam Tucker, Atsushi Nakagaki, Toshihide Sugimura, Shin Fukuda, Makoto Katsuno, Tsutomu Fujita, Naoto Izumi, Nozomi Suzuki, Kazuhiro Sako Source Type: research

Racial Disparity in the Prescription of Anticoagulants and Risk of Stroke and Bleeding in Atrial Fibrillation Patients
Background: Oral anticoagulant (OAC) therapy is proven to be effective at reducing risk of stroke in patients with atrial fibrillation (AF). However, racial minorities with AF are less likely to be prescribed vitamin K anticoagulants (VKA). There is little information on the racial disparity in the prescription of the non-vitamin K oral anticoagulants (NOACs) and the associated risks of stroke and bleeding. Methods: We used data from the Northwestern Medicine Enterprise Data Warehouse – a joint initiative across 11 Northwestern Medicine affiliated healthcare centers within metropolitan Chicago, Illinois.
Source: Journal of Stroke and Cerebrovascular Diseases - February 27, 2020 Category: Neurology Authors: Yacob G. Tedla, Sarah M. Schwartz, Philip Silberman, Philip Greenland, Rod S. Passman Source Type: research

Neutrophil-to-lymphocyte ratio at admission is a risk factor for in-hospital gastrointestinal bleeding in acute ischemic stroke patients after dual antiplatelet therapy: A case control study
Gastrointestinal bleeding is a clinically important complication in acute ischemic stroke patients after dual antiplatelet therapy. The present study was to explore the association between neutrophil-to-lymphocyte ratio (NLR) and in-hospital gastrointestinal  bleeding in acute ischemic stroke (AIS) patients who had received dual antiplatelet therapy.
Source: Journal of Stroke and Cerebrovascular Diseases - September 1, 2023 Category: Neurology Authors: Jiaming Huang, Foqiang Liao, Yeting Luo, Xu Shu Source Type: research

Case Report: A 70-Year-Old Man with Undiagnosed Factor VII Deficiency Presented with Acute Ischemic Stroke
We report a case of unusual clinical presentation in a patient with undiagnosed factor VII deficiency who presented with acute ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2013 Category: Neurology Authors: Hing-Lung Ip, Anne Yin-Yan Chan, Kit-Chung Ng, Yannie Oi-Yan Soo, Lawrence Ka-Sing Wong Tags: Case Reports Source Type: research

Endovascular Treatment for Cerebral Septic Embolic Stroke
This case demonstrates an alternative approach to cerebral revascularization by performing both intravascular mechanical thrombectomy and local injection of thrombolytics that may reduce mortality, bleeding, and the diminished quality of life experienced by patients following an acute septic embolic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2014 Category: Neurology Authors: Hadi D. Toeg, Talal Al-Atassi, Navya Kalidindi, Daniela Iancu, Delara Zamani, Roberto Giaccone, Roy G. Masters Tags: Case Reports Source Type: research

Protocol for Cerebral Microbleeds During the Non–Vitamin K Antagonist Oral Anticoagulants or Warfarin Therapy in Stroke Patients With Nonvalvular Atrial Fibrillation (CMB-NOW) Study: Multisite Pilot Trial
Anticoagulants are widely used to prevent recurrence of ischemic stroke in patients with nonvalvular atrial fibrillation, but in some patients, they also cause bleeding, particularly intracranial hemorrhage. One of the independent predictors of intracerebral hemorrhage is the presence of cerebral microbleeds (CMBs); a high incidence of intracerebral hemorrhage is reported in warfarin-treated patients with multiple CMBs. Longitudinal study suggested that the presence of CMBs at baseline is a predictor of new CMBs in warfarin-treated patients.
Source: Journal of Stroke and Cerebrovascular Diseases - July 4, 2015 Category: Neurology Authors: Shunya Takizawa, Fumiaki Tanaka, Kazutoshi Nishiyama, Yasuhiro Hasegawa, Eiichiro Nagata, Atsushi Mizuma, Sachiko Yutani, Taira Nakayama, Hiroyuki Kobayashi, Noriharu Yanagimachi, Takashi Okazaki, Kazuo Kitagawa, CMB-NOW Study Investigators Source Type: research

Gastrointestinal Bleeding in Acute Ischemic Stroke: A Population-Based Analysis of Hospitalizations in the United States
Over half of all patients admitted with acute ischemic stroke (AIS) suffer gastrointestinal complications. Our goal was to determine the burden of gastrointestinal bleeding (GIB) in hospitalized patients with AIS using the largest, all-payer, inpatient database in the United States.
Source: Journal of Stroke and Cerebrovascular Diseases - April 13, 2016 Category: Neurology Authors: Kavelin Rumalla, Manoj K. Mittal Source Type: research

Endovascular recanalization therapy in the patients with acute ischemic stroke and active malignancy
【Background】Patients with cancer who have acute ischemic stroke are often precluded from intravenous tPA due to high risk of bleeding. In this case, endovascular recanalization therapy may be an alternative treatment option.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2017 Category: Neurology Authors: Man-Seok Park, Bang-Hoon Cho, Kang-Ho Choi, Joon-Tae Kim, Seung-Han Lee, Woong Yoon, Ki-Hyun Cho Source Type: research

Investigation of optimum conditions of iodine extraction image in after recanalization therapy of acute ischemic stroke
【Background and Purpose】After acute recanalization of ischemic stroke, we distinguish contrast agent leakand bleeding by dual energy CT (DECT). Discrimination confirmed the contrast agent leakage in Iodine map (IM), and confirmed bleeding in the Virtual non-contrast. However, the analysis in the default setting of IM would extract the lateral ventricle (LV). The purpose of this study is to make IM more clearly with different method which is using ΔCT values.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2017 Category: Neurology Authors: Kotaro Fukuda, Masataka Hayashi, Shizuka Nishikawa, Rika Fukui, Isao Tanaka Source Type: research

Associations of Antithrombotic Timing and Regimen with Ischemic Stroke and Bleeding Complications in Blunt Cerebrovascular Injury
Blunt carotid injuries and vertebral arterial injuries, collectively referred to as blunt cerebrovascular injuries (BCVIs), are generally rare events but are associated with high mortality rates and long-term health effects.1 The long-term effects of BCVI include loss of both cognition and function, including the ability to perform daily cognitive and mobility activities without assistance, recurrent stroke, and need for extensive rehabilitation.2-6 Blunt cerebrovascular injuries have been reported to occur in 0.1-0.7% of all trauma patients in the United States,7-10 although higher rates ( ∼1-2%) have been reported afte...
Source: Journal of Stroke and Cerebrovascular Diseases - April 14, 2020 Category: Neurology Authors: Daniel Barrera, Erica Sercy, Alessandro Orlando, Charles W. Mains, Robert Madayag, Matthew M. Carrick, Allen Tanner, Mark Lieser, David Acuna, James Yon, David Bar-Or Source Type: research

Risk analysis of post-procedural intracranial hemorrhage based on STAY ALIVE Acute Stroke Registry
Intracranial hemorrhages (ICH) are classified as symptomatic or asymptomatic according to the presence of clinical deterioration. Here, we aimed to find predictive factors of symptomatic intracranial bleeding in a registry-based stroke research.
Source: Journal of Stroke and Cerebrovascular Diseases - May 9, 2020 Category: Neurology Authors: Peter Csecsei, Gabor Tarkanyi, Edit Bosnyak, Laszlo Szapary, Gabor Lenzser, Alex Szolics, Andras Buki, Peter Hegyi, Alan Abada, Tihamer Molnar Source Type: research

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