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High-frequency operation of pulsatile ventricular assist devices: A computational study on circular and elliptically shaped pumps.
Abstract Pulsatile positive displacement pumps as ventricular assist devices were gradually replaced by rotary devices due to their large volume and high adverse event rates. Nevertheless, pulsatile ventricular assist devices might be beneficial with regard to gastrointestinal bleeding and cardiac recovery. Therefore, aim of this study was to investigate the flow field in new pulsatile ventricular assist devices concepts with an increased pump frequency, which would allow lower stroke volumes to reduce the pump size. We developed a novel elliptically shaped pulsatile ventricular assist devices, which we compared t...
Source: The International Journal of Artificial Organs - July 4, 2019 Category: Transplant Surgery Authors: Loosli C, Rupp S, Thamsen B, Rebholz M, Kress G, Meboldt M, Ermanni P Tags: Int J Artif Organs Source Type: research

Long-term follow-up of continuous flow left ventricular assist devices: complications and predisposing risk factors.
CONCLUSIONS: LVADs are associated with significant long-term complications including stroke and sepsis and minimizing time on LVADs may decrease the risk of complications and subsequent morbidity and mortality. PMID: 28777392 [PubMed - as supplied by publisher]
Source: The International Journal of Artificial Organs - August 2, 2017 Category: Transplant Surgery Authors: Adesiyun TA, McLean RC, Tedford RJ, Whitman GJR, Sciortino CM, Conte JV, Shah AS, Russell SD Tags: Int J Artif Organs Source Type: research

Atrial fibrillation in dialysis patients: time to abandon warfarin?
Abstract Atrial fibrillation (AF) is a frequent clinical complication in dialysis patients, and warfarin therapy represents the most common approach for reducing the risk of stroke in this population. However, current evidence based on observational studies, offer conflicting results, whereas no randomized controlled trials have been carried out so far. Additionally, many clinicians are wary of the possible role of warfarin as vascular calcification inducer and its potential to increase the high risk of bleeding among patients on dialysis. Ideally the most promising therapy would be based on direct inhibitors of f...
Source: The International Journal of Artificial Organs - April 8, 2016 Category: Transplant Surgery Authors: Brancaccio D, Neri L, Bellocchio F, Barbieri C, Amato C, Mari F, Canaud B, Stuard S Tags: Int J Artif Organs Source Type: research

Low incidence of gastrointestinal bleeding and pump thrombosis in patients receiving the INCOR LVAD system in the long-term follow-up.
CONCLUSIONS: In this cohort of high-risk, advanced HF patients, the INCOR LVAD provided effective support with improved survival. Moreover, the absence of GI bleeding and pump thrombosis demonstrates a favorable characteristic of this device. Further prospective studies are needed to confirm these data. PMID: 26541278 [PubMed - as supplied by publisher]
Source: The International Journal of Artificial Organs - October 28, 2015 Category: Transplant Surgery Authors: Iacovoni A, Centofanti P, Attisani M, Verde A, Terzi A, Senni M, Maiani M, Baronetto A, Livi U, Frigerio M, Rinaldi M Tags: Int J Artif Organs Source Type: research

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