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Left atrial appendage closure for stroke prevention in non-valvular atrial fibrillation: rationale, devices in clinical development and insights into implantation techniques.
CONCLUSIONS: Catheter-based LAA occlusion is now being developed further as an interventional approach for stroke prevention in patients with atrial fibrillation. Implantation techniques and devices are being improved, which will probably result in better procedural safety. Appropriate operator training is of major importance for this approach. PMID: 25138187 [PubMed - in process]
Source: EuroIntervention - November 12, 2014 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Left atrial appendage closure: patient, device and post-procedure drug selection.
Authors: Tzikas A, Bergmann MW Abstract Left atrial appendage closure (LAAC), a device-based therapy for stroke prevention in patients with atrial fibrillation, is considered an alternative to oral anticoagulation therapy, particularly for patients at high risk of bleeding. Proof of concept has been demonstrated by the PROTECT AF and PREVAIL trials which evaluated the WATCHMAN device (Boston Scientific, Marlborough, MA, USA) versus warfarin, showing favourable outcome for the device group. The most commonly used devices for LAAC are the WATCHMAN and its successor, the WATCHMAN FLX (Boston Scientific) and the AMPLAT...
Source: EuroIntervention - May 15, 2016 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research