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DL-3-n-butylphthalide Promotes Neuroplasticity and Motor Recovery in Stroke Rats.
CONCLUSION: dl-NBP enhanced the behavioral recovery after cerebral ischemia in rats, possibly by increasing axonal growth and neurogenesis. PMID: 28442357 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - April 22, 2017 Category: Neurology Authors: Sun Y, Cheng X, Wang H, Mu X, Liang Y, Luo Y, Qu H, Zhao C Tags: Behav Brain Res Source Type: research

Characterization of Long-term Gait Deficits in Mouse dMCAO, Using the CatWalk System.
Abstract Evaluation of functional outcome is widely used across species to assess the recovery process following various pathological conditions, including spinal cord injury, musculo-skeletal injury, mithochondrial disease, neuropathic cancer, Huntington's disease, chronic pain, cortical lesion, and olivocerebellar degeneration among others. The Stroke Therapy Academic Industry Roundtable (STAIR) recommends multiple endpoints for behavioral studies in pre-clinical stroke research, to demonstrate their clinical relevance. One of the more challenging tasks in experimental stroke research is measuring long-term func...
Source: Behavioural Brain Research - May 23, 2017 Category: Neurology Authors: Caballero-Garrido E, Pena-Philippides JC, Galochkina Z, Erhardt E, Roitbak T Tags: Behav Brain Res Source Type: research

Quantitative gait analysis of long-term locomotion deficits in classical unilateral striatal intracerebral hemorrhage rat model.
Abstract Gait analysis is a systematic collection of quantitative information on bodily movements during locomotion. Gait analysis has been employed clinically in stroke patients for their rehabilitation planning. In animal studies, gait analysis has been employed for the assessment their locomotive disturbances in ischemic stroke, spinal cord injury and Parkinson's disease. The aims of the work reported here were to identify the gait parameters, collected from the computer-generated CatWalk System, that change after unilateral intracerebral hemorrhage (ICH) in the acute stage and long term up to 56 days post-ICH....
Source: Behavioural Brain Research - October 11, 2013 Category: Neurology Authors: Liu Y, Ao LJ, Lu G, Leong E, Liu Q, Wang XH, Zhu XL, Sun TF, Fei Z, Jiu T, Hu X, Poon WS Tags: Behav Brain Res Source Type: research

A new method to assess weight-bearing distribution after central nervous system lesions in rats.
Abstract The aim of the present study is to assess the relevance of weight-bearing distribution (DWB) measurement in freely moving rats after stroke and thoracic spinal cord injuries. Animals were divided in 2 experiments: 1) The middle cerebral artery occlusion-reperfusion (MCAO-r) experiment containing the MCAO group in which focal brain ischemia was induced by transient MCA occlusion and 2) the thoracic hemisection experiment containing the TH group in which a spinal cord hemisection was performed at the T10 level. A Control and respective Sham groups were also included in each experiment. Not only the pressure...
Source: Behavioural Brain Research - November 4, 2013 Category: Neurology Authors: Pertici V, Pin-Barre C, Felix MS, Laurin J, Brisswalter J, Decherchi P Tags: Behav Brain Res Source Type: research

Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors.
Abstract Twenty-nine protein kinase inhibitors have been used to treat human diseases. Out of these, two are Rho-associated protein kinase (ROCK) 1 and 2 inhibitors. The ROCKs heavily influence neuronal architecture and structural plasticity, and ROCKs are putative drug targets for various brain disorders. While the pan-ROCK inhibitor Fasudil has been clinically approved to treat hypertension, heart failure, glaucoma, spinal cord injury, and stroke, a barrier to progress on this therapeutic avenue is the lack of experimental comparisons between pharmacologic and genetic manipulation of ROCKs. Our study begins to a...
Source: Behavioural Brain Research - July 10, 2019 Category: Neurology Authors: Greathouse KM, Henderson BW, Gentry EG, Herskowitz JH Tags: Behav Brain Res Source Type: research

Preserved Intersegmental Coordination During Locomotion after Cervical Spinal Cord Injury in Common Marmosets
In this study, we used a common marmoset hemisection SCI model to examine temporal changes in locomotor pattern, in particular, intersegmental coordination of left hindlimb. Marmoset showed loss of detectable function in the left forelimb and hindlimb after left unilateral hemisection of cervical spinal cord. At two weeks after injury, weight-bearing of the left forelimb during locomotion was limited, but the left hindlimb was able to plantar step. Then marmosets showed gradual recovery in walking ability, but kinematics analysis showed differences in the endpoint trajectory and joint angle movement. Furthermore, intersegm...
Source: Behavioural Brain Research - March 1, 2022 Category: Neurology Authors: Yuta Sato Takahiro Kondo Akito Uchida Kenta Sato Kimika Yoshino-Saito Masaya Nakamura Hideyuki Okano Junichi Ushiba Source Type: research

Preserved intersegmental coordination during locomotion after cervical spinal cord injury in common marmosets
In this study, we used a common marmoset hemisection SCI model to examine temporal changes in locomotor pattern, in particular, intersegmental coordination of left hindlimb. Marmoset showed loss of detectable function in the left forelimb and hindlimb after left unilateral hemisection of cervical spinal cord. At two weeks after injury, weight-bearing of the left forelimb during locomotion was limited, but the left hindlimb was able to plantar step. Then marmosets showed gradual recovery in walking ability, but kinematics analysis showed differences in the endpoint trajectory and joint angle movement. Furthermore, intersegm...
Source: Behavioural Brain Research - March 1, 2022 Category: Neurology Authors: Yuta Sato Takahiro Kondo Akito Uchida Kenta Sato Kimika Yoshino-Saito Masaya Nakamura Hideyuki Okano Junichi Ushiba Source Type: research