• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Interleukin ‐17A and vascular remodelling in severe asthma; lack of evidence for a direct role
Conclusions & Clinical RelevanceOur results shed light on the role of IL‐17A in vascular remodelling, most likely through stimulating the synthesis of other angiogenic factors. Knowledge of these pathways may aid in the identification of new therapeutic targets.
Source: Clinical and Experimental Allergy - February 20, 2018 Category: Allergy & Immunology Authors: A. Panariti, C. J. Baglole, V. Sanchez, D. H. Eidelman, S. Hussain, R. Olivenstein, J. G. Martin, Q. Hamid Tags: ORIGINAL ARTICLE Source Type: research

Advancing the management of Obstructive Airways Diseases through Translational Research
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - February 7, 2018 Category: Allergy & Immunology Authors: Celeste Porsbjerg, Asger Sverrild, Katherine J Baines, Andrew Searles, Steven Maltby, Paul S. Foster, Chris Brightling, Peter G. Gibson Tags: Invited Review Source Type: research

Interleukin ‐17A and vascular remodeling in severe asthma; lack of evidence for a direct role
Conclusions & Clinical RelevanceOur results shed light on the role of IL‐17A in vascular remodeling, most likely through stimulating the synthesis of other angiogenic factors. Knowledge of these pathways may aid in the identification of new therapeutic targets.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - January 1, 2018 Category: Allergy & Immunology Authors: Alice Panariti, Carolyn J Baglole, Veronica Sanchez, David H Eidelman, Sabah Hussain, Ron Olivenstein, James G. Martin, Qutayba Hamid Tags: Original Article ‐Asthma and Rhinitis Source Type: research

Atopy in people aged 40  years and over: Relation to airflow limitation
Conclusion and Clinical RelevanceThe apparent association between atopy and post‐bronchodilator airflow limitation in the general population appears to be explained by the association between atopy and having ever diagnosed asthma and the effect of asthma on lung function.
Source: Clinical and Experimental Allergy - November 2, 2017 Category: Allergy & Immunology Authors: E. M. Guevara ‐Rattray, F. L. Garden, A. L. James, R. Wood‐Baker, M. J. Abramson, D. P. Johns, A. Sonia Buist, P. G. J. Burney, E. Haydn Walters, B. G. Toelle, G. B. Marks Tags: ORIGINAL ARTICLE Source Type: research

Atopy in people aged 40 and over: relation to airflow limitation
Conclusion and Clinical RelevanceThe apparent association between atopy and post‐bronchodilator airflow limitation in the general population appears to be explained by the association between atopy and having ever diagnosed asthma and the effect of asthma on lung function.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - October 1, 2017 Category: Allergy & Immunology Authors: Elyse Marie Guevara ‐Rattray, Frances L. Garden, Alan L. James, Richard Wood‐Baker, Michael J. Abramson, David P. Johns, A. Sonia Buist, Peter G.J. Burney, E. Haydn Walters, Brett G. Toelle, Guy B. Marks Tags: Original Article ‐Epidemiology of Allergic Disease Source Type: research

Comorbidities in adults with asthma: population ‐based cross‐sectional analysis of 1.4 million adults in Scotland
Conclusions and Clinical RelevancePhysical and mental health comorbidity is the norm in adults with asthma. Appropriate recognition and management should form part of routine asthma care.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - June 30, 2017 Category: Allergy & Immunology Authors: Christopher J Weatherburn, Bruce Guthrie, Stewart W Mercer, Daniel R Morales Tags: Original Article ‐Asthma and Rhinitis Source Type: research

A clustering approach to identify and characterize the asthma and chronic obstructive pulmonary disease overlap phenotype
Conclusions & Clinical RelevanceThe asthma‐COPD overlap phenotype was characterized by peripheral blood eosinophilia and higher levels of IgE despite the Th2‐low endotype.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - June 1, 2017 Category: Allergy & Immunology Authors: Keita Hirai, Toshihiro Shirai, Masayuki Suzuki, Taisuke Akamatsu, Takahito Suzuki, Ichiro Hayashi, Akito Yamamoto, Takefumi Akita, Satoru Morita, Kazuhiro Asada, Daiki Tsuji, Kazuyuki Inoue, Kunihiko Itoh Tags: Original Article ‐Asthma and Rhinitis Source Type: research

Reference ranges for serum periostin in a population without asthma or chronic obstructive pulmonary disease
Conclusions and Clinical RelevanceSerum periostin levels in adults without asthma or COPD are similar to those in adults with asthma. Serum periostin measurements do not need to be adjusted to take account of a patient's age or sex, although levels are lower in current smokers. Reference values for serum periostin levels in adults without asthma or COPD are provided.
Source: Clinical and Experimental Allergy - June 27, 2016 Category: Allergy & Immunology Authors: R. Caswell‐Smith, A. Hosking, T. Cripps, C. Holweg, J. Matthews, M. Holliday, C. Maillot, J. Fingleton, M. Weatherall, I. Braithwaite, R. Beasley, Tags: Original Article Source Type: research

Reference ranges for serum periostin in a population without asthma or copd
Conclusions and clinical relevanceSerum periostin levels in adults without asthma or COPD are similar to those in adults with asthma. Serum periostin measurements do not need to be adjusted to take account of a patient's age or sex, although levels are lower in current smokers. Reference values for serum periostin levels in adults without asthma or COPD are provided.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - May 29, 2016 Category: Allergy & Immunology Authors: Rachel Caswell‐Smith, Alexander Hosking, Terrianne Cripps, Cecile Holweg, John Matthews, Mark Holliday, Corentin Maillot, James Fingleton, Mark Weatherall, Irene Braithwaite, Richard Beasley Tags: Original Article ‐Asthma and Rhinitis Source Type: research

Severe or life ‐threatening asthma exacerbation: patient heterogeneity identified by cluster analysis
Conclusions & Clinical RelevanceThis study demonstrated that significant heterogeneity exists among patients with severe or life‐threatening asthma exacerbation. Differences were observed in the severity of asthma symptoms and use of inhaled corticosteroids at baseline, and the presence of comorbid COPD. These findings may contribute to a deeper understanding and better management of this patient population.
Source: Clinical and Experimental Allergy - May 23, 2016 Category: Allergy & Immunology Authors: K. Sekiya, E. Nakatani, Y. Fukutomi, H. Kaneda, M. Iikura, M. Yoshida, K. Takahashi, K. Tomii, M. Nishikawa, N. Kaneko, Y. Sugino, M. Shinkai, T. Ueda, Y. Tanikawa, T. Shirai, M. Hirabayashi, T. Aoki, T. Kato, K. Iizuka, S. Homma, M. Taniguchi, H. Tanaka Tags: Original Article Source Type: research

Clinical approaches towards asthma and chronic obstructive pulmonary disease based on the heterogeneity of disease pathogenesis
Summary Asthma and chronic obstructive pulmonary disease (COPD) are each heterogeneous disease classifications that include several clinical and pathophysiological phenotypes. This heterogeneity complicates characterization of each disease and, in some cases, hinders the selection of appropriate treatment. Therefore, in recent years, emphasis has been placed on improving our understanding of the various phenotypes of asthma and of COPD and identifying biomarkers for each phenotype. Likewise, the concept of the endotype has been gaining acceptance; an endotype is a disease subtype that is defined by unique or distinctive fu...
Source: Clinical and Experimental Allergy - April 25, 2016 Category: Allergy & Immunology Authors: N. Hizawa Tags: Review Source Type: research

Effect of roflumilast on airway remodelling in a murine model of chronic asthma
ConclusionsThese results suggest that the administration of roflumilast regulates airway inflammation, AHR, and airway remodelling in a model of chronic asthma. The beneficial effects from roflumilast may be related to the SCF/c‐kit pathway.
Source: Clinical and Experimental Allergy - April 25, 2016 Category: Allergy & Immunology Authors: S. W. Kim, J. H. Kim, C. K. Park, T. J. Kim, S. Y. Lee, Y. K. Kim, S. S. Kwon, C. K. Rhee, H. K. Yoon Tags: Original Article Source Type: research

Human bronchial and parenchymal fibroblasts display differences in basal inflammatory phenotype and response to IL‐17A
Conclusions and Clinical RelevanceThese findings provide insight into the inflammatory and remodeling processes that may be related to the phenotypic heterogeneity of fibroblasts from airway and parenchymal regions and in their response to IL‐17A.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - April 14, 2016 Category: Allergy & Immunology Authors: Kevin Dessalle, Venkatesan Narayanan, Shigenori Kyoh, Andrea Mogas, Andrew J. Halayko, Parameswaran Nair, Carolyn J. Baglole, David H. Eidelman, Mara S. Ludwig, Qutayba Hamid Tags: Original Article ‐Asthma and Rhinitis Source Type: research

Severe or life‐threatening asthma exacerbation: patient heterogeneity identified by cluster analysis
Conclusions & Clinical RelevanceThis study demonstrated that significant heterogeneity exists among patients with severe or life‐threatening asthma exacerbation. Differences were observed in the severity of asthma symptoms and use of inhaled corticosteroids at baseline, and the presence of comorbid COPD. These findings may contribute to a deeper understanding and better management of this patient population.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - March 31, 2016 Category: Allergy & Immunology Authors: Kiyoshi Sekiya, Eiji Nakatani, Yuma Fukutomi, Hideaki Kaneda, Motoyasu Iikura, Makoto Yoshida, Ken‐ichi Takahashi, Keisuke Tomii, Masanori Nishikawa, Norihiro Kaneko, Yasuteru Sugino, Masaharu Shinkai, Tetsuya Ueda, Yoshimasa Tanikawa, Toshihiro Shirai, Tags: Original Article ‐Asthma and Rhinitis Source Type: research

Lung–gut cross‐talk: evidence, mechanisms and implications for the mucosal inflammatory diseases
Summary The mucosal immune system (including airway, intestinal, oral and cervical epithelium) is an integrated network of tissues, cells and effector molecules that protect the host from environmental insults and infections at mucous membrane surfaces. Dysregulation of immunity at mucosal surfaces is thought to be responsible for the alarming global increase in mucosal inflammatory diseases such as those affecting the gastrointestinal (Crohn's disease, ulcerative colitis and irritable bowel syndrome) and respiratory (asthma, allergy and chronic obstructive pulmonary disorder) system. Although immune regulation has been we...
Source: Clinical and Experimental Allergy - March 28, 2016 Category: Allergy & Immunology Authors: M. K. Tulic, T. Piche, V. Verhasselt Tags: Review Source Type: research

Pages: 1  2