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Condition: Arthritis
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Evaluation of TAK-242 (Resatorvid) Effects on Inflammatory Status of Fibroblast-like Synoviocytes in Rheumatoid Arthritis and Trauma Patients
Iran J Allergy Asthma Immunol. 2021 Aug 7;20(4):453-464.ABSTRACTFibroblast-like synoviocytes (FLSs) produce lots of inflammatory molecules that trigger immune responses and intensification the inflammation and thereby play important roles in Rheumatoid Arthritis )RA( pathogenesis. Due to the important roles of toll-like receptor 4 (TLR4) in cytokine production and inflammation, we aimed to evaluate the effects of TAK-242 (Resatorvid) on interleukin (IL)1-β, IL-6, TNF-α, and TLR4 expression and two important proteins of nuclear factor-κB (NF-κB) signaling pathway (Ikβα and pIkβα) in RA and trauma FLSs. FLSs were iso...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 22, 2021 Category: Allergy & Immunology Authors: Jafar Karami Elham Farhadi Ali-Akbar Delbandi Mehdi Shekarabi Mohammad Naghi Tahmasebi Arash Sharafat Vaziri Maryam Akhtari Mohammad Javad Mousavi Ahmadreza Jamshidi Mahdi Mahmoudi Source Type: research
