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Condition: Polyps
Procedure: Laryngoscopy
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Total 45 results found since Jan 2013.
Olfactory and middle meatal cytokine levels correlate with olfactory function in chronic rhinosinusitis
ConclusionsThe inflammatory microenvironment within the olfactory cleft mirrors that within the middle meatus. Elevated levels of IL‐2, IL‐5, IL‐6, IL‐10, and IL‐13 in olfactory cleft mucus are associated with reduced olfactory identification scores in CRS patients. Altered levels of select olfactory mucus cytokines could potentially have deleterious effects on olfactory neuron function and turnover.
Level of EvidenceNA. Laryngoscope, 2018
Source: The Laryngoscope - February 8, 2018 Category: ENT & OMF Authors: Jeffanie Wu, Rakesh K. Chandra, Ping Li, Benjamin P. Hull, Justin H. Turner Tags: Allergy/Rhinology Source Type: research
Absence or mislocalization of DNAH5 is a characteristic marker for motile ciliary abnormality in nasal polyps
ConclusionOur results suggest that the absence or mislocalization of DNAH5 from motile cilia is a common and potentially important pathological phenomenon in chronically inflamed airway epithelium.
Level of EvidenceNA. Laryngoscope, 2017
Source: The Laryngoscope - November 17, 2017 Category: ENT & OMF Authors: Qianhui Qiu, Yang Peng, Zhenchao Zhu, Zhuo Chen, Chi Zhang, Hsiao Hui Ong, Kai Sen Tan, Haiyu Hong, Yan Yan, Haoqi Huang, Jing Liu, Xianqing Li, H.N. Nam, N.T.N. Dung, Li Shi, Qintai Yang, Colin D. Bingle, De ‐Yun Wang Tags: Allergy/Rhinology Source Type: research
Lack of long ‐term add‐on effect by montelukast in postoperative chronic rhinosinusitis patients with nasal polyps
ConclusionsThese results suggest that the addition of montelukast to INCS should not be recommended in the treatment of postoperative CRSwNP patients.
Level of Evidence1b Laryngoscope, 2017
Source: The Laryngoscope - November 8, 2017 Category: ENT & OMF Authors: Laura Van Gerven, Cristobal Langdon, Arturo Cordero, Sara Cardel ús, Joaquim Mullol, Isam Alobid Tags: Allergy/Rhinology Source Type: research
Effect of matrix metalloproteinase inhibitor on disrupted E ‐cadherin after acid exposure in the human nasal epithelium
ConclusionOur results suggest that altered expression of E‐cadherin in the nasal epithelium by acid exposure may be a possible mechanism for nasal tissue injury in chronic nasal inflammation with LPRD, and that MMP inhibition is a potential treatment.
Level of EvidenceNA. Laryngoscope, 2017
Source: The Laryngoscope - October 17, 2017 Category: ENT & OMF Authors: Byoungjae Kim, Hyun ‐Ji Lee, Nu‐Ri Im, Doh Young Lee, Cha Young Kang, Il‐Ho Park, Seung Hoon Lee, Sang Hag Lee, Seung‐Kuk Baek, Tae Hoon Kim Tags: Allergy/Rhinology Source Type: research
Randomized controlled trial of steroid ‐soaked absorbable calcium alginate nasal packing following endoscopic sinus surgery
ConclusionsThis study demonstrated that steroid‐soaked, absorbable nasal packing can be used to enhance wound healing after endoscopic sinus surgery and to prevent polypoid changes in the nasal mucosa.
Level of Evidence1b. Laryngoscope, 2017
Source: The Laryngoscope - September 22, 2017 Category: ENT & OMF Authors: Chi Sang Hwang, Salma Saud Sharhan, Bo Ra Kim, Soo In Kim, Jin Woong Kim, Hyung ‐Ju Cho, Joo‐Heon Yoon, Chang‐Hoon Kim Tags: Allergy/Rhinology Source Type: research
A paradigm for evaluation and management of the maxillary sinus before dental implantation
ConclusionCraniofacial CT is crucial for pre‐dental implantation sinonasal evaluation. The risk of dental implant‐related chronic rhinosinusitis is low for patients with cysts, polyps, or mucosal thickening in the maxillary sinus. However, preventive endoscopic sinus surgery is recommended for patients with incurable chronic rhinosinusitis, fungal sinusitis, and large polyps or cysts.
Level of Evidence4. Laryngoscope, 2017
Source: The Laryngoscope - September 16, 2017 Category: ENT & OMF Authors: Yi ‐Wei Chen, Fu‐Ying Lee, Po‐Hung Chang, Chi‐Che Huang, Chia‐Hsiang Fu, Chien‐Chia Huang, Ta‐Jen Lee Tags: Allergy/Rhinology Source Type: research
Chemosensory function before and after multimodal treatment in chronic rhinosinusitis patients
ConclusionsPatients suffering from CRS with polyps exhibit olfactory and taste dysfunctions. Multimodal treatment leads to an improvement in olfactory, but not gustatory functionality.
Level of Evidence4. Laryngoscope, 2017
Source: The Laryngoscope - September 12, 2017 Category: ENT & OMF Authors: Ute Walliczek ‐Dworschak, Robert Pellegrino, Franziska Taube, Christian A. Mueller, Boris Alexander Stuck, Philipp Dworschak, Christian Güldner, Silke Steinbach Tags: Allergy/Rhinology Source Type: research
The value of frontal sinusotomy for chronic rhinosinusitis with nasal polyps —A cost utility analysis
ConclusionsESS remains a cost‐effective intervention compared to medical therapy alone for patients with CRSwNP. In this study, the addition of frontal sinusotomy during ESS for patients with CRSwNP was not found to be cost‐effective at a WTP threshold of $50,000/QALY, but may be cost effective at a higher threshold of $100,000/QALY.
Level of Evidence2C. Laryngoscope, 2017
Source: The Laryngoscope - August 1, 2017 Category: ENT & OMF Authors: George A. Scangas, Ashton E. Lehmann, Aaron K. Remenschneider, Brooke M. Su, Mark G. Shrime, Ralph Metson Tags: Allergy/Rhinology Source Type: research
Association between systemic antibiotic and corticosteroid use for chronic rhinosinusitis and quality of life
ConclusionMore frequent past CRS‐related oral antibiotic and corticosteroid use, regardless of time period queried (3 months or 12 months) is associated with significant decrease in CRS‐specific and general health‐related QoL. CRS‐related systemic medication use is an important indicator of CRS patients' QOL that easily can be queried and utilized in both clinical and research settings.
Level of Evidence2c. Laryngoscope, 2017
Source: The Laryngoscope - July 21, 2017 Category: ENT & OMF Authors: Alisa Yamasaki, Lloyd P. Hoehle, Katie M. Phillips, Allen L. Feng, Adam P. Campbell, David S. Caradonna, Stacey T. Gray, Ahmad R. Sedaghat Tags: Allergy/Rhinology Source Type: research
Revision rates and time to revision following endoscopic sinus surgery: A large database analysis
ConclusionsA minority of patients with CRS who undergo ESS will have a revision surgery. This likelihood is increased in female patients and those with nasal polyps, and decreased in patients of Hispanic ethnicity, even when controlling for income, insurance, and hospital setting.
Level of Evidence4. Laryngoscope, 2017
Source: The Laryngoscope - July 8, 2017 Category: ENT & OMF Authors: Nathan R. Stein, Aria Jafari, Adam S. DeConde Tags: Allergy/Rhinology Source Type: research
Role of fungi in chronic rhinosinusitis through ITS sequencing
ConclusionFungal biomass estimated through ITS amplicon concentration correlated with traditional fungal detection techniques and CT double densities. Our results suggest that fungal dysbiosis only occurs in the sinuses of a selected subset of patients, and therefore could not be a universal determinant of sinus disease pathogenesis in all CRS patients.
Level of EvidenceNA. Laryngoscope, 2017
Source: The Laryngoscope - July 1, 2017 Category: ENT & OMF Authors: Yi Chen Zhao, Ahmed Bassiouni, Kangsadarn Tanjararak, Sarah Vreugde, Peter ‐John Wormald, Alkis James Psaltis Tags: Allergy/Rhinology Source Type: research
Exosomes mediate interepithelial transfer of functional P ‐glycoprotein in chronic rhinosinusitis with nasal polyps
ConclusionHere we demonstrate the presence and P‐gp enrichment of mucus‐derived exosomes, or rhinosomes, in CRSwNP. These rhinosomes are capable of rapid intercellular transfer of P‐gp, leading to increased P‐gp function within recipient cells. This represents a novel mechanism for maintaining P‐gp overexpression in CRSwNP, and more generally for interepithelial transfer of other proteins between mucosal epithelial cells.
Level of EvidenceNA. Laryngoscope, 2017
Source: The Laryngoscope - May 9, 2017 Category: ENT & OMF Authors: Angela L. Nocera, Marcel M. Miyake, Philip Seifert, Xue Han, Benjamin S. Bleier Tags: Allergy/Rhinology Source Type: research
Prevalence of polyp recurrence after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis
ConclusionsPolyp recurrence is common after ESS with control of polyps up to 18 months found in approximately 60% to 70% of patients. Investigation into both surgical and medical management strategies is warranted to improve upon the observed prevalence of recurrence.
Level of Evidence2c. Laryngoscope, 2016
Source: The Laryngoscope - November 11, 2016 Category: ENT & OMF Authors: Adam S. DeConde, Jess C. Mace, Joshua M. Levy, Luke Rudmik, Jeremiah A. Alt, Timothy L. Smith Tags: Allergy/Rhinology Source Type: research
Balloon dilation of sinus ostia in the Department of Defense: Diagnoses, actual indications, and outcomes
ConclusionsBalloon dilation of sinus ostia has an expanding role in treating sinus disease. In the studied population, BCD is often utilized for alternate indications for which there is currently no evidence of efficacy. Future studies are needed to evaluate the efficacy of this technology in treating these alternate indications.
Level of Evidence4. Laryngoscope, 2016
Source: The Laryngoscope - September 23, 2016 Category: ENT & OMF Authors: Adrienne M. Laury, Sarah N. Bowe, Joshua Stramiello, Kevin C. McMains Tags: Allergy/Rhinology Source Type: research
Predicting revision sinus surgery in allergic fungal and eosinophilic mucin chronic rhinosinusitis
ConclusionThe presence of eosinophilic mucin was significantly associated a higher rate of revision surgery.
Level of Evidence4. Laryngoscope, 2016
Source: The Laryngoscope - August 30, 2016 Category: ENT & OMF Authors: Ramzi T. Younis, Jamal Ahmed Tags: Allergy/Rhinology Source Type: research
