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Source: European Respiratory Journal
Condition: Polyps

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Total 36 results found since Jan 2013.

Dupilumab increases aspirin tolerance in NSAID-exacerbated respiratory disease
Conclusion In this study, 57% of N-ERD patients tolerated higher doses of aspirin under dupilumab therapy.
Source: European Respiratory Journal - March 16, 2023 Category: Respiratory Medicine Authors: Schneider, S., Poglitsch, K., Morgenstern, C., Quint, T., Gangl, K., Sinz, C., Bartosik, T., Campion, N. J., Liu, D. T., Landegger, L. D., Tu, A., Stanek, V., Rocha-Hasler, M., Bangert, C., Eckl-Dorna, J. Tags: Asthma and allergy Original Articles: Asthma and allergy Source Type: research

Living without eosinophils: evidence from mouse and man
The enduring view of eosinophils, as immune effector cells whose primary function is host defence against infection by helminths and other microbial pathogens, sets the stage for a fundamental question regarding the safety of therapeutic eosinophil depletion. If eosinophils are significantly reduced or altogether depleted in an effort to alleviate the negative effects of tissue eosinophilia and eosinophilic inflammation in conditions such as asthma, COPD, chronic rhinosinusitis with nasal polyps, eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome, would these patients become susceptible to infecti...
Source: European Respiratory Journal - January 12, 2023 Category: Respiratory Medicine Authors: Jackson, D. J., Pavord, I. D. Tags: Asthma and allergy Reviews Source Type: research

Onset, Maintenance, and Durability of Response with Dupilumab in Chronic Rhinosinusitis with Nasal Polyps
Conclusion: By W16, more dupilumab than pbo pts achieved clinically relevant response (onset), with the response maintained at W52 in >82% of dupilumab pts.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Bachert, C., Khan, A., Fokkens, W., Hopkins, C., Gevaert, P., Han, J., Hellings, P., Lee, S., Msihid, J., Nash, S., Siddiqui, S., Jacob-Nara, J., Deniz, Y., Rowe, P. Tags: 05.03 - Allergy and immunology Source Type: research

Multidisciplinary checklist approach for the 'severe phenotype: Asthma with Nasal Polyps
Asthma with chronic rhinosinusitis with nasal polyps (CRSwNP) associates with higher burden and more difficult treatment.Aim: To propose an evidence-based data checklist for a coordinated management of these patients.A multidisciplinary team of ENT physicians, allergologists, pneumologists and hospital pharmacist aimed to develop a checklist for the assessment of patients, based on the diagnostic definition, and the control and severity criteria establish in guidelines such GINA, ARIA, EPOS, and international consensus on biologic therapies for CRSwNP and Asthma from EUFOREA and from EAACI, and a multidisciplinary consensu...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Castillo Vizuete, J. A., Armengot, M., Delgado, J., Gil, M., Colas, C., Plasencia, I., Cisneros, C. Tags: 05.03 - Allergy and immunology Source Type: research

Transcriptomic analysis of cellular senescence signatures in severe asthma
Conclusions: Cellular senescence may be involved in the pathophysiology of severe asthma, particularly in patients with comorbid nasal polyps. Further studies are warranted to validate the causal relationships.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Song, W., Zounemat-Kermani, N., Guo, Y., Adcock, I., Chung, K. F. Tags: 05.03 - Allergy and immunology Source Type: research

Type 2 biomarker expression according to age of asthma onset: an analysis of the German severe asthma registry (GAN)
Conclusion: Severe adult-onset asthma is characterised by a stronger expression of type 2 biomarkers than severe early-onset asthma.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Lommatzsch, M., Taube, C., Hamelmann, E., Milger-Kneidinger, K., Skowasch, D., Jandl, M., Schmitz, F. S., Koerner-Rettberg, C., Idzko, M., Buhl, R., Korn, S. Tags: 05.03 - Allergy and immunology Source Type: research

Association between Staphylococcal Enterotoxin (SE)-specific IgE and specific IgE for house dust mites (HDM) in Brazilian patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).
SE are a group of superantigens formerly associated with several respiratory diseases, including asthma, rhinitis and CRSwNP. Superantigens trigger the production of high specific IgE levels and are usually related to high levels of total IgE (tIgE) and eosinophilic inflammation.We aim to evaluate the correlation between the positivity of SE-specific IgE for A; B; C; TSST-1; tIgE and specific IgE for D. pteronyssinus (DP); D. farinae (DF) and B. tropicalis (BT) in CRSwNP Brazilian patients.36 CSRwNP patients, defined by 2012-EPOS (European Position Paper on Rhinosinusitis) criteria, submitted to nasal endoscopy and CT...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Campos Dos Santos, P., Dortas Junior, S., Elabras Filho, J., Da Cruz, F., Valle, S., Ferraiolo, P. Tags: 05.03 - Allergy and immunology Source Type: research

SNOT-22 items and association with objective measures in dupilumab-treated patients with severe chronic rhinosinusitis with nasal polyps from SINUS-24 and SINUS-52 trials
Conclusions: A higher percentage of dupilumab-treated pts improved in symptoms most important to pts (smell/taste; nasal blockage) vs PBO. Improvement in these symptoms signals greater improvement in objective measures (LMK and NPS). SNOT-22 item improvement (Wk 24)Least squares mean difference vs PBO (Wk 24)Smell/tasteYes/noNasal blockageYes/noNPS–1.78*/–1.19*–1.90*/–1.01*LMK–5.77*/–4.26*–6.22*/–3.28**P<0.0001 vs PBO
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Mullol, J., Canonica, G. W., Wagenmann, M., Coste, A., Hellings, P., Nash, S., Kamat, S., Mujumdar, U., Msihid, J., Khan, A. H., Siddiqui, S., Jacob-Nara, J. A., Deniz, Y., Rowe, P. Tags: Allergy and immunology Source Type: research

Patient characteristics and treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in Canada
Conclusions: Medical and surgical management was frequently observed in this large CRSwNP cohort and one third also had asthma. Further data on the rate of recurrence leading to retreatment and associated costs are needed to understand the economic burden of CRSwNP in Canada.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Szabo, S., Gendron, A., Deighton, A., Dragan, R., Detillieux, G., Prior, H., Noorduyn, S. Tags: Allergy and immunology Source Type: research

Sex Differences in Severe Asthma
Conclusion: Sex differences in asthma and severe asthma are well described with various putative mechanisms proposed. We demonstrate that signals of type 2 inflammation in blood and sputum are more frequently seen in males than females, despite a comparable level of corticosteroid therapy.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Azim, A., Barber, C., Lau, L., Harvey, M., Dennison, P., Brown, T., Jones, T., Elliot, S., Chauhan, A., Kurukulaaratchy, R., Howarth, P. Tags: Allergy and immunology Source Type: research

Late Breaking Abstract - Response to mepolizumab in patients with severe CRSwNP using EUFOREA 2021 criteria
Conclusion: Clinical response, as defined by the modified EUFOREA criteria, was greater with mepolizumab than placebo and increased from Week 24 to Week 52, suggesting a sustained, progressive response in patients with severe CRSwNP without sinus surgery during the study.Funding: GSK 205687/NCT03085797
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Hopkins, C., Han, J. K., Lund, V. J., Bachert, C., Diamant, Z., Fokkens, W., Sousa, A. R., Smith, S. G., Yang, S., Mayer, B., Yancey, S. W., Chan, R., Lee, S. E. Tags: Airway pharmacology and treatment Source Type: research

Computed tomography (CT) in children with long-term synonasal symptoms (SNS)
Conclusions: Thus, 66.7% of pediatric and adolescent patients with prolonged SNS had CT signs of cystic, cystic-polyposis, and polyposis SM changes. These changes, in our opinion, should be considered in the aspect of the onset of CRS formation with or without polyps in children and adolescents.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Gluhova, M., Eruslankin, N., Grachev, K., Ignatov, G., Krasilnikova, S., Eliseeva, T., Bulgakova, V., Klimanov, I., Popova, N. Tags: Paediatric asthma and allergy Source Type: research

Type 2 inflammation-related comorbidities among patients with asthma, chronic rhinosinusitis with nasal polyps, and atopic dermatitis
Conclusions: High proportions of pts with m/s asthma, m/s AD, and m/s CRSwNP had comorbidities linked to T2 inflammation. Given the high comorbidity burden, an integrated treatment approach addressing underlying T2 inflammation should be considered.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Khan, A., Gouia, I., Kamat, S., Ortiz, B., Johnson, R., Siddall, J., Small, M. Tags: Allergy and immunology Source Type: research

Effect of mepolizumab on chronic rhinosinusitis symptoms and nasal hypersensitivity in patients with or without nasal polyps
Conclusions: In SEA patients with CRSwNP a positive effect in reducing symptoms, nasal hypersensitivity and NP was seen however, a larger number of patients is needed in order to have conclusive results
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Rovina, N., Tsami, M., Panagiotou, M., Syrigou, E., Koulouris, N. Tags: Allergy and immunology Source Type: research

Dupilumab reduces blood and nasal biomarkers of type 2 inflammation in patients with chronic rhinosinusitis with nasal polyps with and without comorbid asthma: SINUS-52 trial
Conclusion: DPL suppressed both systemic (in blood) and local (in nasal secretions) type 2 inflammatory biomarkers in pts with CRSwNP with/without comorbid asthma.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Bachert, C., Mullol, J., Daizadeh, N., Wolfe, K., Ortiz, B., Johnson, R., Deniz, Y., Rowe, P., Mannent, L., Amin, N., Harel, S., Jagerschmidt, A. Tags: Allergy and immunology Source Type: research