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Associations of Tissue and Soluble LOX-1 with Human Abdominal Aortic Aneurysm
Conclusions In AAA, sLOX-1 was differently affected by age, cardiometabolic diseases, and corresponding medical therapies. Comparison with nonatherosclerotic disease would be beneficial to further elucidate the diagnostic potential of sLOX-1, although it was not useful for risk stratification. Aneurysmal LOX-1 mRNA expression was increased and positively associated with smooth muscle cells and collagen content, suggesting that LOX-1 is eventually not deleterious in human AAA and could counteract AAA rupture.PMID:37421287 | DOI:10.1161/JAHA.122.027537
Source: Atherosclerosis - July 8, 2023 Category: Cardiology Authors: Anja Hofmann Yazan Khorzom Anna Klimova Steffen Wolk Albert Busch Pamela Sabarstinski Margarete M üglich Dmitry Egorov Irakli Kopaliani David M Poitz Marvin Kapalla Bianca Hamann Frieda Frank Christian J änichen Coy Brunssen Henning Morawietz Christian Source Type: research

Arterial Atherosclerosis: Vascular Surgery Interventions
Am Fam Physician. 2022 Jan 1;105(1):65-72.ABSTRACTAtherosclerotic vascular disease is a leading cause of death worldwide. Atherosclerotic stenosis of the internal carotid or intracranial arteries causes up to 15% of strokes. Peripheral artery disease affects up to one in five people in the United States who are 60 years and older and nearly one-half of those who are 85 years and older. Renal artery stenosis may affect up to 5% of people with isolated hypertension and up to 40% of people with other atherosclerotic diseases. All patients with atherosclerotic vascular disease should receive a comprehensive program of guidelin...
Source: Atherosclerosis - January 14, 2022 Category: Cardiology Authors: Jonathon M Firnhaber C S Powell Source Type: research