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No Significant Effect of 7,8-Dihydroxyflavone on APP Processing and Alzheimer-Associated Phenotypes.
In this study we examined whether DHFaffectsAPP processing and cognitive functionsin vitro and in vivo.We found that DHF had no significant effect on amyloid β precursor protein (APP), BACE1 and amyloid β protein (Aβ). DHF had little effect on APP processing in cell cultures.DHF treatment did not reduce the deposition of Aβ to form neuritic plaques in the brain of AD model mice APP23/PS45.Furthermore, DHF did not alleviate learning and memory impairments in the AD model mice. Our study suggest that further extensive and careful studies are warranted for considering DHF as a new therapeutic agent for reducing amyloid pa...
Source: Current Alzheimer Research - December 18, 2014 Category: Neurology Authors: Zhou W, Li X, Huang D, Zhou W, Li T, Song W Tags: Curr Alzheimer Res Source Type: research

Newly Diagnosed Dementia and Increased Risk of Hemorrhagic Stroke: A Nationwide Population-based Study.
Conclusion: Individuals with dementia, especially Alzheimer's disease, are at greater risk of developing stroke, especially in intracerebral and subarachnoid hemorrhage than patients without dementia. Early mental screening programs and health education should be initiated for dementia patients. PMID: 24484279 [PubMed - as supplied by publisher]
Source: Current Alzheimer Research - January 31, 2014 Category: Neurology Authors: Wang HK, Tsai KJ, Huang CY, Wang LC, Lu K, Chen HJ, Lin CW, Lee YJ, Fang PH, Chang LC, Li YC Tags: Curr Alzheimer Res Source Type: research

Butyrylcholinesterase K and Apolipoprotein ε4 Affect Cortical Thickness and Neuropsychiatric Symptoms in Alzheimer's Disease.
This study analyzed the effects of the BChE and ApoE genotypes on the cortical thickness of patients with AD and examined how these genotypes affect the neuropsychiatric symptoms of AD. AD-drug-naïve patients who met the probable AD criteria proposed by the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association were recruited. Of 96 patients with AD, 65 were eligible for cortical thickness analysis. 3D T1-weighted images were acquired, and the cortical regions were segmented using the constrained Laplacian-based automated segmentation with proximitie...
Source: Current Alzheimer Research - January 30, 2014 Category: Neurology Authors: Yoo HB, Lee HW, Shin S, Park SW, Choi JS, Jung HY, Cha J, Lee JM, Lee JY Tags: Curr Alzheimer Res Source Type: research

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