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Protective effect of alpha-linoleic acid on A β-induced oxidative stress, neuroinflammation, and memory impairment by alteration of α7 nAChR and NMDAR gene expression in the hippocampus of rats
Neurotoxicology. 2021 Jun 7;85:245-253. doi: 10.1016/j.neuro.2021.06.002. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative disorder that affects many older people around the world. Numerous studies are underway to evaluate the protective effects of natural products in AD. Alpha-linoleic acid (ALA) is an essential unsaturated fatty acid that exhibits neuroprotective outcomes in rat models of ischemic stroke and Parkinson's disease. This research aimed to investigate the effect of ALA on oxidative stress, neuroinflammation, neuronal death, and memory deficit induced by amyloid-beta (A...
Source: Neurotoxicology - June 10, 2021 Category: Neurology Authors: Nahaleh Tofighi Masoumeh Asle-Rousta Mehdi Rahnema Rahim Amini Source Type: research

Association between aluminum in drinking water and incident Alzheimer's disease in the Canadian Study of Health and Aging cohort.
Abstract Epidemiological evidence linking aluminum in drinking water and Alzheimer's disease (AD) has been inconsistent, with previous studies often limited by small sample sizes. The present study addresses this issue using data from the Canadian Study of Health and Aging (CSHA), a prospective cohort of 10,263 subjects followed-up from 1991-1992 through 2001-2002. Participants' residential histories were linked to municipal drinking water sources in 35 Canadian municipalities to obtain ecologic pH, aluminum, fluoride, iron and silica concentrations in drinking water. Cox proportional hazards models were used to e...
Source: Neurotoxicology - April 28, 2020 Category: Neurology Authors: Van Dyke N, Yenugadhati N, Birkett NJ, Lindsay J, Turner MC, Willhite CC, Krewski D Tags: Neurotoxicology Source Type: research

Neuroprotective effects of edaravone on cognitive deficit, oxidative stress and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats.
Abstract Oxidative stress is implicated as an important factor in the development of Alzheimer's disease (AD). In the present study, we have investigated the effects of edaravone (9mg/kg, 3-Methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, in a streptozotocin (STZ-3mg/kg) induced rat model of sporadic AD (sAD). Treatment with edaravone significantly improved STZ-induced cognitive damage as evaluated in Morris water maze and step-down tests and markedly restored changes in malondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE) adducts, hydroxyl radical (·OH), hydrogen peroxide (H2O2), total superoxide dism...
Source: Neurotoxicology - August 6, 2013 Category: Neurology Authors: Zhou S, Yu G, Chi L, Zhu J, Zhang W, Zhang Y, Zhang L Tags: Neurotoxicology Source Type: research