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DL-3-n-butylphthalide Promotes Neuroplasticity and Motor Recovery in Stroke Rats.
CONCLUSION: dl-NBP enhanced the behavioral recovery after cerebral ischemia in rats, possibly by increasing axonal growth and neurogenesis. PMID: 28442357 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - April 22, 2017 Category: Neurology Authors: Sun Y, Cheng X, Wang H, Mu X, Liang Y, Luo Y, Qu H, Zhao C Tags: Behav Brain Res Source Type: research

Behavioural inflexibility in a comorbid rat model of striatal ischemic injury and mutant hAPP overexpression.
Abstract Alzheimer disease (AD) and stroke coexist and interact; yet how they interact is not sufficiently understood. Both AD and basal ganglia stroke can impair behavioural flexibility, which can be reliably modeled in rats using an established operant based set-shifting test. Transgenic Fischer 344-APP21 rats (TgF344) overexpress pathogenic human amyloid precursor protein (hAPP) but do not spontaneously develop overt pathology, hence TgF344 rats can be used to model the effect of vascular injury in the prodromal stages of Alzheimer disease. We demonstrate that the injection of endothelin-1 (ET1) into the dorsal...
Source: Behavioural Brain Research - July 7, 2017 Category: Neurology Authors: Levit A, Regis AM, Garabon JR, Oh SH, Desai S, Rajakumar N, Hachinski V, Agca Y, Agca C, Whitehead SN, Allman BL Tags: Behav Brain Res Source Type: research