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Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging
ObjectiveRecent availability of amyloid and tau positron emission tomography (PET) has provided us with a unique opportunity to measure the association of systemic vascular health with brain health after accounting for the impact of Alzheimer disease (AD) pathologies. We wanted to quantify early cerebrovascular health –related magnetic resonance imaging brain measures (structure, perfusion, microstructural integrity) and evaluate their utility as a biomarker for cerebrovascular health.MethodsWe used 2 independent samples (discovery, n  = 390; validation, n = 1,035) of individuals, aged ≥ 60 years, along the...
Source: Annals of Neurology - October 25, 2018 Category: Neurology Authors: Prashanthi Vemuri, Timothy G. Lesnick, Scott A. Przybelski, Jonathan Graff ‐Radford, Robert I. Reid, Val J. Lowe, Samantha M. Zuk, Matthew L. Senjem, Christopher G. Schwarz, Jeffrey L. Gunter, Kejal Kantarci, Mary M. Machulda, Michelle M. Mi Tags: Research Article Source Type: research

Building on NeuroNEXT: “Next Generation” Clinics to Cure Chronic Neurological Disability
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - November 24, 2017 Category: Neurology Authors: Rajiv R. Ratan Tags: Letter to the Editor Source Type: research

Age, vascular health, and Alzheimer disease biomarkers in an elderly sample
ObjectiveTo investigate the associations between age, vascular health, and Alzheimer disease (AD) imaging biomarkers in an elderly sample. MethodsWe identified 430 individuals along the cognitive continuum aged >60 years with amyloid positron emission tomography (PET), tau PET, and magnetic resonance imaging (MRI) scans from the population‐based Mayo Clinic Study of Aging. A subset of 329 individuals had fluorodeoxyglucose (FDG) PET. We ascertained presently existing cardiovascular and metabolic conditions (CMC) from health care records and used the summation of presence/absence of hypertension, hyperlipidemia, cardia...
Source: Annals of Neurology - October 26, 2017 Category: Neurology Authors: Prashanthi Vemuri, Timothy G. Lesnick, Scott A. Przybelski, David S. Knopman, Val J. Lowe, Jonathan Graff ‐Radford, Rosebud O. Roberts, Michelle M. Mielke, Mary M. Machulda, Ronald C. Petersen, Clifford R. Jack Tags: Research Article Source Type: research

Age, Vascular Health, and Alzheimer's disease Biomarkers in an Elderly Sample
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Source: Annals of Neurology - October 10, 2017 Category: Neurology Authors: Prashanthi Vemuri, Timothy G. Lesnick, Scott A. Przybelski, David S. Knopman, Val J. Lowe, Jonathan Graff ‐Radford, Rosebud O. Roberts, Michelle M. Mielke, Mary M. Machulda, Ronald C. Petersen, Clifford R. Jack Tags: Research Article Source Type: research

The Burden of Neurological Disease in the United States: A Summary Report and Call to Action
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Source: Annals of Neurology - December 31, 2016 Category: Neurology Authors: Clifton L. Gooch, Etienne Pracht, Amy R. Borenstein Tags: Invited Editorial Source Type: research

Shared genetic contribution to ischemic stroke and Alzheimer's disease
ObjectiveIncreasing evidence suggests epidemiological and pathological links between Alzheimer's disease (AD) and ischemic stroke (IS). We investigated the evidence that shared genetic factors underpin the two diseases. MethodsUsing genome‐wide association study (GWAS) data from METASTROKE + (15,916 IS cases and 68,826 controls) and the International Genomics of Alzheimer's Project (IGAP; 17,008 AD cases and 37,154 controls), we evaluated known associations with AD and IS. On the subset of data for which we could obtain compatible genotype‐level data (4,610 IS cases, 1,281 AD cases, and 14,320 controls), we estimat...
Source: Annals of Neurology - March 29, 2016 Category: Neurology Authors: Matthew Traylor, Poneh Adib‐Samii, Denise Harold, , Martin Dichgans, Julie Williams, Cathryn M. Lewis, Hugh S. Markus, Tags: Research Article Source Type: research

Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease
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Source: Annals of Neurology - February 1, 2016 Category: Neurology Authors: Matthew Traylor, Poneh Adib‐Samii, Denise Harold, , , Martin Dichgans, Julie Williams, Cathryn M. Lewis, Hugh S. Markus, , Tags: Research Article Source Type: research

Mediterranean diet, stroke, cognitive impairment, and depression: A meta‐analysis
ObjectiveThis meta‐analysis aims to quantitatively synthesize all studies that examine the association between adherence to a Mediterranean diet and risk of stroke, depression, cognitive impairment, and Parkinson disease. MethodsPotentially eligible publications were those providing effect estimates of relative risk (RR) for the association between Mediterranean diet and the aforementioned outcomes. Studies were sought in PubMed up to October 31, 2012. Maximally adjusted effect estimates were extracted; separate analyses were performed for high and moderate adherence. ResultsTwenty‐two eligible studies were included (1...
Source: Annals of Neurology - September 16, 2013 Category: Neurology Authors: Theodora Psaltopoulou, Theodoros N. Sergentanis, Demosthenes B. Panagiotakos, Ioannis N. Sergentanis, Rena Kosti, Nikolaos Scarmeas Tags: Original Article Source Type: research

Mediterranean diet and stroke, cognitive impairment, depression: A meta‐analysis
Abstract OBJECTIVE: This meta‐analysis aims to quantitatively synthesize all studies that examine the association between adherence to a Mediterranean diet and risk of stroke, depression, cognitive impairment and Parkinson's disease. METHODS: Potentially eligible publications were those providing effect estimates of relative risk (RR) for the association between Mediterranean diet and the aforementioned outcomes. Studies were sought in PubMed up to October 31, 2012. Maximally adjusted effect estimates were extracted; separate analyses were performed for high and moderate adherence. RESULTS: 22 eligible studies were inclu...
Source: Annals of Neurology - May 1, 2013 Category: Neurology Authors: Theodora Psaltopoulou, Theodoros N. Sergentanis, Demosthenes B. Panagiotakos, Ioannis N. Sergentanis, Rena Kosti, Nikolaos Scarmeas Tags: Research Article Source Type: research

G protein–coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation‐induced sensitization to excitotoxic neurodegeneration
ObjectiveThe concept of inflammation‐induced sensitization is emerging in the field of perinatal brain injury, stroke, Alzheimer disease, and multiple sclerosis. However, mechanisms underpinning this process remain unidentified. MethodsWe combined in vivo systemic lipopolysaccharide‐induced or interleukin (IL)−1β–induced sensitization of neonatal and adult rodent cortical neurons to excitotoxic neurodegeneration with in vitro IL‐1β sensitization of human and rodent neurons to excitotoxic neurodegeneration. Within these inflammation‐induced sensitization models, we assessed metabotropic glutamate receptors (mG...
Source: Annals of Neurology - March 14, 2013 Category: Neurology Authors: Vincent Degos, Stéphane Peineau, Cora Nijboer, Angela M. Kaindl, Stéphanie Sigaut, Géraldine Favrais, Frank Plaisant, Natacha Teissier, Elodie Gouadon, Alain Lombet, Elie Saliba, Graham L. Collingridge, Mervyn Maze, Ferdinando Nicoletti, Cobi Heijnen, Tags: Research Article Source Type: research

GRK2 and group I mGluR mediate inflammation‐induced sensitization to excitotoxic neurodegeneration
Abstract Objectives:The concept of inflammation‐induced sensitization is emerging in the field of perinatal brain injury, stroke, Alzheimer disease and multiple sclerosis. However, mechanisms underpinning this process remain unidentified. Methods:We combined in vivo systemic lipopolysaccharide (LPS) or Interleukin‐1β (IL‐1β) induced sensitization of neonatal and adult rodent cortical neurons to excitotoxic neurodegeneration with in vitroIL‐1β sensitization of human and rodent neurons to excitotoxic neurodegeneration. Within these inflammation‐induced sensitization models we assessed metabotropic glutamatergic ...
Source: Annals of Neurology - February 11, 2013 Category: Neurology Authors: Vincent Degos, Stéphane Peineau, Cora Nijboer, Angela M. Kaindl, Stéphanie Sigaut, Géraldine Favrais, Frank Plaisant, Natacha Teissier, Elodie Gouadon, Alain Lombet, Elie Saliba, Graham L. Collingridge, Mervyn Maze, Ferdinando Nicoletti, Cobi Heijnen, Tags: Research Article Source Type: research