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CSF biomarkers suggest a strong role of glial inflammation in the pathogenesis of frontotemporal dementia (P6.104)
Conclusions:FTD features increased YKL-40, sTREM2 and NfL, a profile that distinguishes it from controls and AD. The dynamic relationship between CSF neuroinflammatory and injury biomarkers and disease severity support a strong role for neuroinflammation in the progression of FTD.Study Supported by:NIH 2T32 AG023481, National Institutes of Health, 4-Repeat Tauopathy Neuroimaging Initiative (4RTNI, AG03879); the National Center for Advancing Translational Science (NCATS) and National Institute of Neurological Disorders and Stroke (NINDS), Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL, NS09208...
Source: Neurology - April 17, 2017 Category: Neurology Authors: -Martinez, J. R., Calvet, M. S., Karydas, A., Kleinberger, G., Kramer, J., Rosen, H., Rabinovici, G., Miller, B., Fagan, A., Haass, C., Boxer, A. Tags: Aging and Dementia Poster Discussion Session: Novel Approaches in Neurodegenerative Diseases: Genetics, Biomarkers, and Therapies Source Type: research

Aerobic exercise and vascular cognitive impairment: A randomized controlled trial
Conclusions: This study provides preliminary evidence for the efficacy of 6 months of thrice-weekly progressive aerobic training in community-dwelling adults with mild SIVCI, relative to usual care plus education. ClinicalTrials.gov identifier: NCT01027858. Classification of evidence: This study provides Class II evidence that for adults with mild SIVCI, an aerobic exercise program for 6 months results in a small, significant improvement in ADAS-Cog performance.
Source: Neurology - November 13, 2016 Category: Neurology Authors: Liu-Ambrose, T., Best, J. R., Davis, J. C., Eng, J. J., Lee, P. E., Jacova, C., Boyd, L. A., Brasher, P. M., Munkacsy, M., Cheung, W., Hsiung, G.-Y. R. Tags: All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), Vascular dementia, Class I ARTICLE Source Type: research

Brain functional changes after a somatosensory discrimination training in healthy young subjects (S28.004)
Conclusions: These findings suggest that a somatosensory discrimination training of the right hand can facilitate the recruitment of the contralateral primary sensory cortex during tactile stimulation and object manipulation tasks. Furthermore, it determines the use of different brain activation strategies during hand movement. This study suggests that a passive somatosensory discrimination training could be useful for lesion-specific rehabilitation following, e.g., stroke.Disclosure: Dr. sarasso has nothing to disclose. Dr. Agosta has received personal compensation for activities with Biogen Idec and Serono Symposia Inter...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Sarasso, E., Agosta, F., Adamo, P., Temporiti, F., Falini, A., Gatti, R., Filippi, M. Tags: Neuro-rehabilitation Source Type: research

Recommendations of the Alzheimer's Disease-Related Dementias Conference
The National Alzheimer's Project Act, signed into law in 2011, mandates a National Plan to Address Alzheimer's Disease that is updated annually. In the Plan, the term Alzheimer disease includes not only Alzheimer disease (AD) proper, but also several specified related dementias, namely, frontotemporal, Lewy body, vascular, and mixed dementia. In response to a specific action item in the 2012 National Plan, the National Institute of Neurological Disorders and Stroke, in collaboration with the National Institute on Aging, convened panels of experts and conducted a 2-day public conference to develop research priorities and ti...
Source: Neurology - August 25, 2014 Category: Neurology Authors: Montine, T. J., Koroshetz, W. J., Babcock, D., Dickson, D. W., Galpern, W. R., Glymour, M. M., Greenberg, S. M., Hutton, M. L., Knopman, D. S., Kuzmichev, A. N., Manly, J. J., Marder, K. S., Miller, B. L., Phelps, C. H., Seeley, W. W., Sieber, B.-A., Silv Tags: All Cognitive Disorders/Dementia, Alzheimer's disease, Frontotemporal dementia, Parkinson's disease with dementia, Vascular dementia VIEWS & amp;amp; REVIEWS Source Type: research