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Source: Hypertension
Condition: Alzheimer's
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Total 1 results found since Jan 2013.
Abstract P120: Down Regulation of Add3 in Astrocytes Induces Pro-inflammatory and Fibrotic Factors and May Contribute to Alzheimer’S-related Dementias Session Title: Onsite Poster Competition I With Reception
We genetically mapped a mutation in Add3 in FHH rats that decreases Add3 expression in various tissues, including brain and cerebral vessels, and further decreases with age in comparison with FHH.1BN congenic rats in which Chr. 1 from BN rats containing 15 genes, including Add3, was transferred onto FHH genetic background. More recently, we demonstrated that Add3 dysfunction contributes to cerebral vascular impairments in FHH rats, and they exhibit BBB leakage and neurodegeneration after the development of hypertension. In addition, Aβ protein expression in the brain in FHH rats is increased as early as 8 weeks of age. Re...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Paige N Mims, Sheshank Shekhar, Shaoxun Wang, Olivia Travis, Fan Fan Tags: Poster Abstract Presentations Source Type: research
