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UCP2‐related mitochondrial pathway participates in oroxylin A‐induced apoptosis in human colon cancer cells
In conclusion, we have demonstrate that UCP2 play a key role in mitochondrial apoptotic pathway; UCP2's inhibition by oroxylin A triggers the MPTP opening, and promotes the apoptosis in CaCo‐2 cells. J. Cell. Physiol. © 2014 Wiley Periodicals, Inc.
Source: Journal of Cellular Physiology - September 24, 2014 Category: Cytology Authors: Chen Qiao, Libin Wei, Qinsheng Dai, Yuxin Zhou, Qian Yin, Zhiyu Li, Yuanming Xiao, Qinglong Guo, Na Lu Tags: Original Research Article Source Type: research

Sodium Butyrate Induces Apoptosis of Human Colon Cancer Cells by Modulating ERK and Sphingosine Kinase 2.
CONCLUSION: ERK regulates the export of SphK2 and apoptosis of HCT116 cells by modulating PKD. Modulation of these molecules may help increase the sensitivity of colon cancer cells to the physiologic anti-colon cancer agent, NaBT. PMID: 24709100 [PubMed - in process]
Source: Biomedical and Environmental Sciences : BES - March 1, 2014 Category: Biomedical Science Authors: Xiao M, Liu YG, Zou MC, Zou F Tags: Biomed Environ Sci Source Type: research

{beta}1Pix Interacts Directly with {beta}-Catenin Cell Biology
We report the novel observations that β1Pix binds directly to β-catenin, an action requiring both the β1Pix DH and dimerization domains but not β1Pix GEF activity. In human colon cancer cells, activation of β-catenin signaling with LiCl decreased β1Pix/β-catenin association in the cytosol and increased nuclear binding of β-catenin to β1Pix. Nuclear association of β1Pix and β-catenin was independent of Rac1 expression and activation; down- and up-regulating Rac1 expression levels did not alter nuclear β1Pix/β-catenin association. Ectopic β1Pix expression enhanced LiCl-induced β-catenin transcriptional activit...
Source: Journal of Biological Chemistry - November 22, 2013 Category: Chemistry Authors: Chahdi, A., Raufman, J.-P. Tags: Signal Transduction Source Type: research

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