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A review on the role of MEG8 lncRNA in human disorders
Cancer Cell Int. 2022 Sep 16;22(1):285. doi: 10.1186/s12935-022-02705-9.ABSTRACTMaternally expressed 8 (MEG8) is a long non-coding RNA which is expressed in the nucleus. It is highly expressed in adrenal, placenta and brain. Recent studies have shown contribution of MEG8 in different disorders ranging from neoplastic ones to diabetic nephropathy, atherosclerosis, ischemic stroke, trophoblast dysfunction and abortion, Henoch-Schonlein purpura and osteoarthritis. It has an oncogenic role in the development of lung, pancreatic and liver cancer. In the current review, we summarize the role of this lncRNA in mentioned disorders...
Source: Atherosclerosis - September 16, 2022 Category: Cardiology Authors: Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Bashdar Mahmud Hussen Mohammad Taheri Seyedpouzhia Shojaei Source Type: research

Recurrent Strokes as the First Presentation of Occult Pancreatic Cancer; Trousseau Syndrome: A Case Report
We present a case of a 64-year-old female with recurrent ischemic stroke of unknown cause and involving different arterial territories, who was discovered to have metastatic pancreatic cancer. The initial workup with brain imaging revealed multiple acute/subacute ischemic strokes and a negative cardiac assessment. Accordingly, she underwent a whole-body positron emission tomography-computed tomography which revealed a hypermetabolic mass lesion in the pancreaticoduodenal area. Our case indicates that cancer-associated stroke should be seriously evaluated. It demonstrates the critical nature of contemplating hidden cancer i...
Source: Atherosclerosis - January 27, 2022 Category: Cardiology Authors: Firas Al Nidawi Mohamed Wael Mohamed Fatima Taha Daher Alarab Amr Elsayed M Hussein Source Type: research