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Cancer: Neuroblastoma
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Total 288 results found since Jan 2013.
Stabilizing effect of tyrosine trimers on pDNA and siRNA polyplexes.
Abstract
Nine sequence-defined, polycationic oligomers were synthesized containing motifs of three consecutive tyrosines (Y3) as stabilizing components for pDNA and siRNA polyplex assembly. For pDNA, a combination of terminal oligotyrosines and cysteines was necessary and sufficient for stable polyplex formation. Stable siRNA binding required a combination of terminal cysteines and oligotyrosines, as well as a central hydrophobic modification (oligotyrosines or fatty acids). The phenolic group within the aromatic amino acids of Y3 containing oligomers further increased the endosomal buffer capacity. As a result, t...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Troiber C, Edinger D, Kos P, Schreiner L, Kläger R, Herrmann A, Wagner E Tags: Biomaterials Source Type: research
Effect on Cell Cycle Progression by N-Myc Knockdown in SK-N-BE(2) Neuroblastoma Cell Line and ...
ConclusionssiRNA therapy targeted to MYCN may not be effective when administered in combination with STI-571 treatment in cases of neuroblastoma. Therefore, chemotherapeutic drugs that target S or G2-M phase may prove ineffective when applied to cells arrested in the G0/1 phase as the result of MYCN knockdown and STI-571 treatment.
Source: Cancer Research and Treatment - March 30, 2008 Category: Cancer & Oncology Tags: Original Article Source Type: research
