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Total 76 results found since Jan 2013.
Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies
Bioorg Med Chem Lett. 2023 Sep 3:129465. doi: 10.1016/j.bmcl.2023.129465. Online ahead of print.ABSTRACTMitoxantrone (MX) is a robust chemotherapeutic with well-characterized applications in treating certain leukemias and advanced breast and prostate cancers. The canonical mechanism of action associated with MX is its ability to intercalate DNA and inhibit topoisomerase II, giving it the designation of a topoisomerase II poison. Years after FDA approval, investigations have unveiled novel protein-binding partners, such as methyl-CpG-binding domain protein (MBD2), PIM1 serine/threonine kinase, RAD52, and others that may con...
Source: Bioorganic and Medicinal Chemistry Letters - September 5, 2023 Category: Chemistry Authors: Savanna Wallin Sarbjit Singh Gloria E O Borgstahl Amarnath Natarajan Source Type: research
< em > Technical Note: < /em > Newly Reformulated Total and Free PSA Immunoassay on Cobas e411 Analyzer Is Virtually Free from Biotin Interference
CONCLUSION: We concluded that newly reformulated total and free PSA immunoassays are virtually free from biotin interference.PMID:35777806
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Authors: Anindita Ghosh Alejandra Russell Amitava Dasgupta Source Type: research
