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Source: Cell Research
Cancer: Prostate Cancer
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Total 327 results found since Jan 2013.
Suppression of tumor cell lactate-generating signaling pathways eradicates murine PTEN/p53-deficient aggressive-variant prostate cancer via macrophage phagocytosis
CONCLUSIONS: Abrogation of lactate-mediated cross-talk between cancer cells and TAM results in durable ADT-independent tumor control in PTEN/p53-deficient AVPC, and warrants further investigation in clinical trials.PMID:37721526 | DOI:10.1158/1078-0432.CCR-23-1441
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Kiranj Chaudagar Hanna M Hieromnimon Anne Kelley Brian Labadie Jordan Shafran Srikrishnan Rameshbabu Catherine Drovetsky Kaela Bynoe Ani Solanki Erica Markiewicz Xiaobing Fan Massimo Loda Akash Patnaik Source Type: research
Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer
CONCLUSION: Our research demonstrates a closely relationship among CD47 and the immunological microenvironment of prostate cancer, and blocking CD47 can promote macrophages to phagocytosis of prostate cancer cells. Therefore, CD47 may provide novel strategies for potential immunotherapy of prostate cancer.PMID:37719086 | PMC:PMC10505079 | DOI:10.1155/2023/2473075
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Qianqian Wang Chunxaing Feng Yuchun Chen Tianming Peng Yong Li Kunlin Wu Xiaoyong Pu Hanzhong Chen Jiumin Liu Source Type: research
F77 antigen is a promising target for adoptive T cell therapy of prostate cancer
This study entails the generation and evaluation of a second-generation CAR against a carbohydrate antigen on malignant prostate cancer cells. Using a single chain fragment variable (scFv) from an F77-specific mouse monoclonal antibody, we created second-generation CARs with CD28 and CD137 (4-1BB) costimulatory signals. F77 expressing lentiviral CAR T cells produce cytokines and kill tumor cells in a F77 expression-dependent manner. These F77-specific CAR T cells eradicate prostate tumors in a human xenograft model employing PC3 cells. These findings validate F77 as a promising immunotherapeutic target for prostate cancer ...
Source: Cell Research - September 17, 2023 Category: Cytology Authors: Payal Grover Selene Nunez-Cruz John Leferovich Tyra Wentz Atrish Bagchi Michael C Milone Mark I Greene Source Type: research
Comorbidity in patients with Lichen sclerosus: a retrospective cohort study
This study confirmed the association between LS and vulvar cancer (OR = 17.4; 95% CI 12.1-25.3), penis cancer (OR = 9.1; 95% CI 4.3-18.9), prostate cancer (OR = 2.0; 95% CI 1.6-2.4) and breast cancer (OR = 1.6; 95% CI 1.4-1.8). LS was also associated with Crohn´s disease (OR = 2.0; 95% CI 1.6-2.6) and diabetes mellitus type 1 (OR = 1.9; 95% CI 1.6-2.1). The present study revealed novel important data regarding the association of LS with cancer and autoimmune diseases, emphasising the importance of sufficient treatment and follow-up of patients with LS. However, future studies are needed to confirm these results and the po...
Source: Cell Research - September 12, 2023 Category: Cytology Authors: Sandra Jerkovic Gulin Filippa Lundin Oliver Seifert Source Type: research
LMNTD2-AS1 regulates immune cell infiltration and promotes prostate cancer progression by targeting FUS to regulate NRF2 signal pathway
This study aimed to identify lncRNAs associated with overall survival (OS) and progression-free interval (PFI) in prostate cancer (PCa) patients and to elucidate the driving mechanisms and functions of these lncRNAs. We utilized the TCGA database to screen for lncRNAs linked with OS and PFI. KM survival analysis, ROC curve analysis, and Cox survival analysis were employed to assess the prognostic significance of lncRNAs in PCa patients. We conducted a loss-of-function assay to explore the role of lncRNAs in PCa. Correlation analysis was performed to study the relationship between lncRNAs and immune cell infiltration. Lasso...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Haoming Wu Ning Liu Aifeng He Haiyang Li Hui Liu Jinke Qian Weipu Mao Guangbo Fu Source Type: research
Androgen deprivation therapy caused a drastic proliferation of B-cell lymphoma with IgG4-related disease in patients with prostate cancer: a case report
CONCLUSION: This case is the first report of clinical significance regarding the crucial role of estrogen and estrogen receptor β in malignant lymphoma in a patient with IgG4-related disease. Our report aims to raise awareness of the need to carefully select treatment options for prostate cancer patients with IgG4-related disease or lymphoma.PMID:37688628 | DOI:10.1007/s00432-023-05292-y
Source: Cell Research - September 9, 2023 Category: Cytology Authors: Hajime Sasagawa Kazuyuki Numakura Mizuki Mori Mizuki Kobayashi Soki Kashima Ryohei Yamamoto Taketoshi Nara Mitsuru Saito Shintaro Narita Hiroshi Nanjo Tomonori Habuchi Source Type: research
m6A-mediated biogenesis of circDDIT4 inhibits prostate cancer progression by sequestrating ELAVL1/HuR
Mol Cancer Res. 2023 Aug 30. doi: 10.1158/1541-7786.MCR-22-0271. Online ahead of print.ABSTRACTThe pathological significance of the circular RNA DDIT4 (CircDDIT4), which is formed by back-splicing at the 3'-untranslated region (UTR) with a 5' splice acceptor site in exon 2 of linear DDIT4 mRNA, has yet to be determined. Our study found that circDDIT4 is downregulated in prostate cancer (PCa) and functions as a tumor suppressor during PCa progression. By competitively binding to ELAV-like RNA binding protein 1 (ELAVL1/HuR) through its 3'-UTR, circDDIT4 acts as a protein sponge to decrease the expression of PCa-overexpressed...
Source: Cell Research - August 30, 2023 Category: Cytology Authors: Zhe Kong Yali Lu Yue Yang Kun Chang Yan Lin Yan Huang Chenji Wang Lu Zhang Wei Xu Shimin Zhao Yao Li Source Type: research
Knockdown LIMP2 inhibits colorectal cancer cells migration, invasion, and metastasis
Exp Cell Res. 2023 Aug 26:113757. doi: 10.1016/j.yexcr.2023.113757. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a common malignancy worldwide nowadays and liver metastasis is the primary cause of death in patients with CRC. Although lysosomal integral membrane protein 2 (LIMP2) has been reported to play important roles in gastric cancer and prostate cancer, its role in CRC remains unclear. The aim of this study was to investigate the function of LIMP2 in CRC invasion and migration, along with the potential underlying molecular mechanisms. We found that LIMP2 levels were higher in CRC tissues compared to adjace...
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Yu Tian Liumei Liang Junxiong Chen Jiaqi Liu Yixi Su Mengchen Shi Weiqian Li Jingdan Zhang Yanchun Feng Lingyuan He Huanliang Liu Xiangling Yang Source Type: research
SFyNCS detects oncogenic fusions involving non-coding sequences in cancer
Nucleic Acids Res. 2023 Aug 28:gkad705. doi: 10.1093/nar/gkad705. Online ahead of print.ABSTRACTFusion genes are well-known cancer drivers. However, most known oncogenic fusions are protein-coding, and very few involve non-coding sequences due to lack of suitable detection tools. We develop SFyNCS to detect fusions of both protein-coding genes and non-coding sequences from transcriptomic sequencing data. The main advantage of this study is that we use somatic structural variations detected from genomic data to validate fusions detected from transcriptomic data. This allows us to comprehensively evaluate various fusion dete...
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Xiaoming Zhong Jingyun Luan Anqi Yu Anna Lee-Hassett Yuxuan Miao Lixing Yang Source Type: research
HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers
Nucleic Acids Res. 2023 Aug 28:gkad700. doi: 10.1093/nar/gkad700. Online ahead of print.ABSTRACTIncorporation of histone variant H3.3 comprises active territories of chromatin. Exploring the function of H3.3 in prostate cancer (PC), we found that knockout (KO) of H3.3 chaperone HIRA suppresses PC growth in vitro and in xenograft settings, deregulates androgen-induced gene expression and alters androgen receptor (AR) binding within enhancers of target genes. H3.3 affects transcription in multiple ways, including activation of p300 by phosphorylated H3.3 at Ser-31 (H3.3S31Ph), which results in H3K27 acetylation (H3K27Ac) at ...
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Viacheslav M Morozov Alberto Riva Sadia Sarwar Wan-Ju Kim Jianping Li Lei Zhou Jonathan D Licht Yehia Daaka Alexander M Ishov Source Type: research
Generating a murine PTEN null cell line to discover the key role of p110 β-PAK1 in Castration-Resistant Prostate Cancer invasion
This study also shows that PAK1 is a potential target for CRPC treatment. Implications: This study uses a newly generated PTEN null prostate cancer cell line to define a critical functional role of p110β-PAK1 in CRPC migration/invasion. This study also shows that the p110β-PAK1 axis can potentially be a therapeutic target in CRPC metastasis.PMID:37606694 | DOI:10.1158/1541-7786.MCR-22-0808
Source: Cell Research - August 22, 2023 Category: Cytology Authors: Haizhen Wang Yu Zhou Chen Chu Jialing Xiao Shanshan Zheng Manav Korpal Joshua M Korn Tiffany Penaloza Richard Drake Wenjian Gan Xueliang Gao Source Type: research
Role of the DEAD-box RNA helicase DDX5 (p68) in cancer DNA repair, immune suppression, cancer metabolic control, virus infection promotion, and human microbiome (microbiota) negative influence
J Exp Clin Cancer Res. 2023 Aug 19;42(1):213. doi: 10.1186/s13046-023-02787-x.ABSTRACTThere is increasing evidence indicating the significant role of DDX5 (also called p68), acting as a master regulator and a potential biomarker and target, in tumorigenesis, proliferation, metastasis and treatment resistance for cancer therapy. However, DDX5 has also been reported to act as an oncosuppressor. These seemingly contradictory observations can be reconciled by DDX5's role in DNA repair. This is because cancer cell apoptosis and malignant transformation can represent the two possible outcomes of a single process regulated by DDX...
Source: Cell Research - August 18, 2023 Category: Cytology Authors: Fengzhi Li Xiang Ling Sayan Chakraborty Christos Fountzilas Jianmin Wang Anmbreen Jamroze Xiaozhuo Liu Pawel Kalinski Dean G Tang Source Type: research
LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network
CONCLUSION: Our study uncovered a novel molecular mechanism of lncRNA SNHG4 in driving prostate cancer progression and enzalutamide resistance, revealing the critical roles and therapeutic potential of RREB1, SNHG4, RRM2 and let-7 miRNAs in anticancer therapy.PMID:37596700 | DOI:10.1186/s13046-023-02774-2
Source: Cell Research - August 18, 2023 Category: Cytology Authors: Qingzhuo Dong Hui Qiu Chiyuan Piao Zhengxiu Li Xiaolu Cui Source Type: research
SPOP mutations target STING1 signaling in prostate cancer and create therapeutic vulnerabilities to PARP inhibitor-induced growth suppression
CONCLUSIONS: We provide evidence that SPOP is critical in regulating immunosuppressive versus anti-tumor activity downstream of DNA damage-induced STING activation in prostate cancer. PARPi treatment of SPOPmut CRPC alters this NC-STING signaling toward canonical, anti-tumor cGAS-STING-IFN-β signaling, highlighting a novel biomarker-informed treatment strategy for prostate cancer.PMID:37581614 | DOI:10.1158/1078-0432.CCR-23-1439
Source: Cell Research - August 15, 2023 Category: Cytology Authors: Chuandong Geng Man-Chao Zhang Ganiraju C Manyam Jody V Vykoukal Johannes F Fahrmann Shan Peng Cheng Wu Sanghee Park Shakuntala Kondraganti Daoqi Wang Brian D Robinson Massimo Loda Christopher E Barbieri Timothy A Yap Paul G Corn Samir Hanash Bradley M Bro Source Type: research
Spotlight on the Expanding Role of miR-647 in Human Cancers
Adv Biomed Res. 2023 Jun 30;12:170. doi: 10.4103/abr.abr_369_22. eCollection 2023.ABSTRACTMicroRNAs are a large group of small, non-coding ssRNAs (miRNAs) that have an epigenetically pivotal role in gene expression and other biological processes in cells and can be regarded as capable biomarkers for the early detection and management of cancer. The aim of the present review article is to summarize the evidence for recognizing the molecular mechanism, target genes, and clinical significance of miR-647 in different cancers. Multiple studies have demonstrated that aberrant expression of miR-647 could be found in a variety of ...
Source: Cell Research - August 11, 2023 Category: Cytology Authors: Mohammadmahdi Jalili Setayesh Tavakoli Kamran Kargar Milad Rafat Fatemeh R Rad Source Type: research
