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Molecules, Vol. 28, Pages 4381: Natural Bacterial and Fungal Peptides as a Promising Treatment to Defeat Lung Cancer Cells
This article is a literature review of research on compounds of natural origin that can potentially be used as part of NSCLC therapies.
Source: Molecules - May 27, 2023 Category: Chemistry Authors: Kamila Rybczy ńska-Tkaczyk Anna Grenda Anna Jakubczyk Pawe ł Krawczyk Tags: Review Source Type: research

Molecules, Vol. 27, Pages 8901: Quinoxalinones as a Novel Inhibitor Scaffold for EGFR (L858R/T790M/C797S) Tyrosine Kinase: Molecular Docking, Biological Evaluations, and Computational Insights
grotmongkol Combating acquired drug resistance of EGFR tyrosine kinase (TK) is a great challenge and an urgent necessity in the management of non-small cell lung cancers. The advanced EGFR (L858R/T790M/C797S) triple mutation has been recently reported, and there have been no specific drugs approved for this strain. Therefore, our research aimed to search for effective agents that could impede the function of EGFR (L858R/T790M/C797S) TK by the integration of in silico and in vitro approaches. Our in-house quinoxalinone-containing compounds were screened through molecular docking and their biological activity was then ve...
Source: Molecules - December 14, 2022 Category: Chemistry Authors: Utid Suriya Panupong Mahalapbutr Watchara Wimonson Sirilata Yotphan Kiattawee Choowongkomon Thanyada Rungrotmongkol Tags: Article Source Type: research

Molecules, Vol. 27, Pages 894: Evaluation of Anticancer and Antibacterial Activity of Four 4-Thiazolidinone-Based Derivatives
zychowski Heterocycles are commonly known for their unique features, e.g., antibacterial or anticancer properties. Although many synthetic heterocycles, such as 4-thiazolidinone (4-TZD), have been synthesized, their potential applications have not yet been fully investigated. However, many researchers have reported relevant results that can be a basis for the search for new potential drugs. Therefore, the aim of this study was to evaluate the cytotoxic, cytostatic, and antibacterial effects of certain 4-thiazolidinone-based derivatives, Les-3166, Les-5935, Les-6009, and Les-6166, on human fibroblasts (BJ), neuroblastom...
Source: Molecules - January 28, 2022 Category: Chemistry Authors: Bartosz Sk óra Anna Lewi ńska Anna Kryshchyshyn-Dylevych Danylo Kaminskyy Roman Lesyk Konrad A. Szychowski Tags: Article Source Type: research

Molecules, Vol. 25, Pages 2278: Therapeutic Emergence of Rhein as a Potential Anticancer Drug: A Review of Its Molecular Targets and Anticancer Properties
umar B Kunnumakkara According to the World Health Organization (WHO), cancer is the second-highest cause of mortality in the world, and it kills nearly 9.6 million people annually. Besides the fatality of the disease, poor prognosis, cost of conventional therapies, and associated side-effects add more burden to patients, post-diagnosis. Therefore, the search for alternatives for the treatment of cancer that are safe, multi-targeted, effective, and cost-effective has compelled us to go back to ancient systems of medicine. Natural herbs and plant formulations are laden with a variety of phytochemicals. One such compound ...
Source: Molecules - May 11, 2020 Category: Chemistry Authors: Sahu Henamayee Kishore Banik Bethsebie Lalduhsaki Sailo Bano Shabnam Choudhary Harsha Satti Srilakshmi Naidu VGM Seung Ho Baek Kwang Seok Ahn Ajaikumar B Kunnumakkara Tags: Review Source Type: research

Molecules, Vol. 25, Pages 816: Colicin N Mediates Apoptosis and Suppresses Integrin-Modulated Survival in Human Lung Cancer Cells
chai Chaotham The inherent limitations, including serious side-effects and drug resistance, of current chemotherapies necessitate the search for alternative treatments especially for lung cancer. Herein, the anticancer activity of colicin N, bacteria-produced antibiotic peptide, was investigated in various human lung cancer cells. After 24 h of treatment, colicin N at 5–15 µM selectively caused cytotoxicity detected by MTT assay in human lung cancer H460, H292 and H23 cells with no noticeable cell death in human dermal papilla DPCs cells. Flow cytometry analysis of annexin V-FITC/propidium i...
Source: Molecules - February 12, 2020 Category: Chemistry Authors: Wanatchaporn Arunmanee Gea Abigail U. Ecoy Hnin Ei Ei Khine Methawee Duangkaew Eakachai Prompetchara Pithi Chanvorachote Chatchai Chaotham Tags: Article Source Type: research

Molecules, Vol. 22, Pages 132: Hair Growth Promoting and Anticancer Effects of p21-activated kinase 1 (PAK1) Inhibitors Isolated from Different Parts of Alpinia zerumbet
In this study, we evaluated the anti-alopecia and anticancer effects of PAK1 inhibitors isolated from Alpinia zerumbet (alpinia) in cell culture. The bioactive compounds isolated from alpinia were found to markedly promote hair cell growth. Kaempferol-3-O- β-d-glucuronide (KOG) and labdadiene, two of the isolated compounds, increased the proliferation of human follicle dermal papilla cells by approximately 117%–180% and 132%–226%, respectively, at 10–100 μM. MTD (2,5-bis(1E,3E,5E)-6-methoxyhexa-1,3,5-trien-1-yl)-2,5-dihydrofuran) and TMOQ ((E) -2,2,3,3-tetramethyl-8-methylene-7-(oct-6-en-1-yl)octahydro-1H-quinolizi...
Source: Molecules - January 13, 2017 Category: Chemistry Authors: Nozomi Taira Binh Nguyen Shinkichi Tawata Tags: Article Source Type: research