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Cancer: Lung Cancer
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Total 241 results found since Jan 2013.
SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes
CONCLUSIONThese results highlight the cascade of vascular and tissue damage associated with SARS-CoV-2 plasma viremia that underlies its ability to predict COVID-19 disease outcomes.FUNDINGMark and Lisa Schwartz; the National Institutes of Health (U19AI082630); the American Lung Association; the Executive Committee on Research at Massachusetts General Hospital; the Chan Zuckerberg Initiative; Arthur, Sandra, and Sarah Irving for the David P. Ryan, MD, Endowed Chair in Cancer Research; an EMBO Long-Term Fellowship (ALTF 486-2018); a Cancer Research Institute/Bristol Myers Squibb Fellowship (CRI2993); the Harvard Catalyst/Ha...
Source: Clinical Lung Cancer - July 1, 2021 Category: Cancer & Oncology Authors: Yijia Li Alexis M Schneider Arnav Mehta Moshe Sade-Feldman Kyle R Kays Matteo Gentili Nicole C Charland Anna Lk Gonye Irena Gushterova Hargun K Khanna Thomas J LaSalle Kendall M Lavin-Parsons Brendan M Lilley Carl L Lodenstein Kasidet Manakongtreecheep Ju Source Type: research
Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK
CONCLUSION: We propose HCK-driven pulmonary and cutaneous vasculitis as a novel autoinflammatory disorder of IEI.PMID:34536415 | DOI:10.1016/j.jaci.2021.07.046
Source: Clinical Lung Cancer - September 18, 2021 Category: Cancer & Oncology Authors: Veronika Kanderova Tamara Svobodova Simon Borna Martina Fejtkova Vendula Martinu Jana Paderova Michael Svaton Jarmila Kralova Eva Fronkova Adam Klocperk Stepanka Pruhova Min Ae Lee-Kirsch Ludmila Hornofova Miroslav Koblizek Petr Novak Olga Zimmermannova Z Source Type: research
Monitoring patients with uncomplicated common variable immunodeficiency: a systematic review
CONCLUSIONS: There is paucity of evidence-based information to guide the routine monitoring of CVID patients without non-infectious complications. Prospective studies are needed to determine the best monitoring practices in this group of patients.PMID:35264237 | DOI:10.1186/s13223-022-00661-7
Source: Clinical Lung Cancer - March 10, 2022 Category: Cancer & Oncology Authors: Erika Yue Lee Stephen Betschel Eyal Grunebaum Source Type: research
Inhaled Marijuana and the Lung
J Allergy Clin Immunol Pract. 2022 May 21:S2213-2198(22)00495-0. doi: 10.1016/j.jaip.2022.05.009. Online ahead of print.ABSTRACTAlthough vaping has recently increased as a mode of inhaling marijuana and has been associated with numerous and sometimes fatal cases of acute severe lung injury, smoking remains the most common method of inhaling marijuana and has been studied more extensively. Smoking marijuana has been shown to produce modest but significant short-term bronchodilation both in healthy subjects and those with asthma. Long-term effects of habitual marijuana smoking include the following: 1) symptoms of chronic br...
Source: Clinical Lung Cancer - May 24, 2022 Category: Cancer & Oncology Authors: Donald P Tashkin Wan-Cheng Tan Source Type: research
Pre-existing comorbidities shape the immune response associated with severe COVID-19
CONCLUSION: The combinatorial systematic analysis of COVID-19 patient immune signatures, comorbidities, and patient outcomes provides the mechanistic immunological underpinnings of comorbidity-driven patient risk and uncovered comorbidity-driven immune signatures.PMID:35716951 | DOI:10.1016/j.jaci.2022.05.019
Source: Clinical Lung Cancer - June 18, 2022 Category: Cancer & Oncology Authors: Stefanie Kreutmair Manuel Kauffmann Susanne Unger Florian Ingelfinger Nicol ás Gonzalo Núñez Chiara Alberti Donatella De Feo Sinduya Krishnarajah Ekaterina Friebel Can Ulutekin Sepideh Babaei Benjamin Gaborit Mirjam Lutz Nicole Puertas Jurado Nisar P M Source Type: research
Clinical Exome Sequencing of 1000 Families with Complex Immune Phenotypes: Towards comprehensive genomic evaluations
CONCLUSION: This program contributes to our understanding of the diagnostic and clinical utility whole exome analysis on a large scale.CLINICAL: Implication: Comprehensive analysis of exome data has diagnostic and clinical utility for patients with suspected inborn errors of immunity.PMID:35753512 | DOI:10.1016/j.jaci.2022.06.009
Source: Clinical Lung Cancer - June 26, 2022 Category: Cancer & Oncology Authors: Morgan N Similuk Jia Yan Rajarshi Ghosh Andrew J Oler Luis M Franco Michael Setzer Michael Kamen Colleen Jodarski Thomas DiMaggio Joie Davis Rachel Gore Leila Jamal Adrienne Borges Nicole Gentile Julie Niemela Chenery Lowe Kathleen Jevtich Yunting Yu Hale Source Type: research
SARS-CoV-2 omicron: Light at the end of the long pandemic tunnel or another false dawn for immunodeficient patients?
J Allergy Clin Immunol Pract. 2022 Jun 22:S2213-2198(22)00597-9. doi: 10.1016/j.jaip.2022.06.011. Online ahead of print.ABSTRACTCOVID-19 has had a disastrous impact on the world. Apart from at least 6 million deaths, countless COVID-19 survivors are suffering long-term physical and psychiatric morbidity. Hundreds of millions have been plunged into poverty caused by economic misery, particularly in developing nations. Early in the pandemic, it became apparent certain groups of individuals such as the elderly and those with comorbidities were at increased risk of severe disease. In addition, patients with some forms of immun...
Source: Clinical Lung Cancer - June 25, 2022 Category: Cancer & Oncology Authors: Rohan Ameratunga Euphemia Leung See-Tarn Woon Lydia Chan Richard Steele Klaus Lehnert Hilary Longhurst Source Type: research
COMMENTARY: Adjuvant vs Neoadjuvant for Resectable NSCLC? COMMENTARY: Adjuvant vs Neoadjuvant for Resectable NSCLC?
Which is better? Concurrent neoadjuvant chemotherapy and immunotherapy or concurrent adjuvant chemotherapy with immunotherapy for non –small cell lung cancer (NSCLC)?Medscape Medical News
Source: Medscape Allergy Headlines - July 15, 2022 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
Efficacy, safety, and tolerability of lebrikizumab in adolescent patients with uncontrolled asthma (ACOUSTICS)
CONCLUSION: Lebrikizumab 125 mg reduced asthma exacerbation rates in adolescents with uncontrolled asthma. However, the study was prematurely terminated (sponsor's decision) potentially limiting interpretation of results.CLINICAL TRIAL REGISTRATION: NCT01875003 (www.ClinicalTrials.gov).PMID:35846226 | PMC:PMC9281483 | DOI:10.1002/clt2.12176
Source: Clinical Lung Cancer - July 18, 2022 Category: Cancer & Oncology Authors: Stanley J Szefler Graham Roberts Adalberto S Rubin Stefan Zielen Piotr Kuna Oral Alpan Judith Anzures-Cabrera Qiang Chen C écile T J Holweg Janusz Kaminski Wendy S Putnam John G Matthews Nikhil Kamath Source Type: research
Allergic sensitisation impairs lung resident memory CD8 T cell response and virus clearance
CONCLUSION: The allergen sensitised lung microenvironment interferes with the formation of anti-viral resident memory CD8 T cells in lungs and virus clearance. Defective anti-viral memory response might contribute to increased susceptibility of asthma patients to viral exacerbations.PMID:35917932 | DOI:10.1016/j.jaci.2022.07.004
Source: Clinical Lung Cancer - August 2, 2022 Category: Cancer & Oncology Authors: Komal Agrawal Li Ching Ong Susan Monkley Kristofer Th örn Elisabeth Israelsson Engin Baturcam Cassie Rist Karin Sch ön Sophia Blake Bj örn Magnusson James Cartwright Suman Mitra Abilash Ravi Nazanin Zounemat-Kermani Jayendra Kumar Krishnaswamy Nils Y L Source Type: research
