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Astrocytic Chitinase ‐3‐like Protein 1 in Neurological Diseases: Potential Roles and Future Perspectives
AbstractChitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its ability to regulate multiple biological processes, such as the inflammatory response and gene transcriptional signaling activation. Abnormal CHI3L1 expression has been associated with multiple neurological disorders and serves as a biomarker for the early detection of several neurodegenerative diseases. Aberrant CHI3L1 expression is also reportedly associated with brain tumor migration and metastasis, as well as contributions to immune escape, playing important roles in brain tumor progression. CHI3L1 is synthesized and secreted mai...
Source: Journal of Neurochemistry - April 7, 2023 Category: Neuroscience Authors: Fei Li, An Liu, Minggao Zhao, Lanxin Luo Tags: REVIEW Source Type: research

Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation
AbstractBrain adenosine concentrations can reach micromolar concentrations in stressful situations such as stroke, neurodegenerative diseases or hypoxic regions of brain tumours. Adenosine can act by receptor ‐independent mechanism by reversing the reaction catalysed by S‐adenosylhomocysteine (SAH) hydrolase, leading to SAH accumulation and inhibition of S‐adenosylmethionine (SAM)‐dependent methyltransferases. Astrocytes are essential in maintaining brain homeostasis but their pathological activa tion and uncontrolled proliferation plays a role in neurodegeneration and glioma. Adenosine can affect cell proliferatio...
Source: Journal of Neurochemistry - December 6, 2019 Category: Neuroscience Authors: Helena Marcelino, Vanda C. Nogueira, Cec ília R.A. Santos, Patrícia Quelhas, Tiago M.A. Carvalho, João Fonseca‐Gomes, Joana Tomás, Maria J. Diógenes, Ana M. Sebastião, José F. Cascalheira Tags: ORIGINAL ARTICLE Source Type: research