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Cancer: Hepatocellular Carcinoma
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Mechanism of total glucosides from Chishao (Radix Paeoniae Rubra) on proliferation and apoptosis of hepatocellular carcinoma cells via phosphatase and tensin homolog deleted on chromosome ten / phosphatidylinositol 3-kinase / protein kinase B signaling pathway
CONCLUSION: TG-RPR significantly inhibits the proliferation of HepG2 cells in a dose-dependent manner and promotes apoptosis. These results demonstrated TG-RPR has significant inhibitory effect on HepG2 cells. These results identify a critical role of TG-RPR in proliferation and apoptosis of HepG2 cells via modulating PTEN/PI3K/Akt signaling pathway. TG-RPR may offer a promise as a potential pharmaceutical therapy for hepatocellular carcinoma.PMID:34708625 | DOI:10.19852/j.cnki.jtcm.2021.05.003
Source: Journal of Traditional Chinese Medicine - October 28, 2021 Category: Complementary Medicine Authors: Bing-Bing Fan Tian-Jiao Li Xian-Sheng Meng Shuai Wang Yong-Rui Bao Fei Wang Source Type: research
