• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT
In conclusion, our research provided direct evidence that apigenin inhibited tumour growth and metastasis both in vitro and in vivo. Apigenin up-regulated TAGLN and hence down-regulated MMP-9 expression through decreasing phosphorylation of Akt at Ser473 and in particular Thr308 to prevent cell proliferation and migration.
Source: The Journal of Nutritional Biochemistry - June 17, 2013 Category: Biochemistry Authors: Li Chunhua, Lin Donglan, Fu Xiuqiong, Zhang Lihua, Fan Qin, Liu Yawei, Zhao Liang, Wen Ge, Jing Linlin, Zeng Ping, Li Kun, Sun Xuegang Tags: Research Articles Source Type: research

The protein ERp57 contributes to EGF receptor signaling and internalization in MDA‐MB‐468 breast cancer cells
Abstract The disulfide isomerase ERp57 is a soluble protein mainly located in the endoplasmic reticulum, where it acts in the quality control of newly synthesized glycoproteins, in association with calreticulin and calnexin. It has been also detected in other cell compartments, such as the cytosol, the plasma membrane and the nucleus. In these locations it is implicated in various processes, participating in the rapid response to calcitriol, modulating the activity of STAT3 and being requested for the pre‐apoptotic exposure of calreticulin on the plasma membrane. In the present work, the involvement of ERp57 in the activ...
Source: Journal of Cellular Biochemistry - May 20, 2013 Category: Biochemistry Authors: Gaucci Elisa, Altieri Fabio, Carlo Turano, Chichiarelli Silvia Tags: Article Source Type: research

Pages: 1  2  3