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siRNA-induced TRAF6 knockdown promotes the apoptosis and inhibits the invasion of human lung cancer SPC-A1 cells.
Authors: He Z, Huang C, Lin G, Ye Y Abstract Tumor necrosis factor receptor-associated factor 6 (TRAF6) has been found to be involved in multiple cancers. However, the effect of small interfering RNA (siRNA)‑induced knockdown of TRAF6 on the biological behaviors of cancer cells remains unknown. Thus, the present study aimed to investigate the effect of siRNA-induced knockdown of TRAF6 on the biological behaviors of human lung cancer SPC-A1 cells. The expression of TRAF6 was determined in human lung adenocarcinoma A549, non-small cell lung cancer H1650, human airway epithelial Calu-3 and human lung cancer SPC-A1 ...
Source: Oncology Reports - February 9, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TRIM28 knockdown increases sensitivity to etoposide by upregulating E2F1 in non-small cell lung cancer.
Authors: Liu L, Xiao L, Liang X, Chen L, Cheng L, Zhang L, Wu X, Xu Q, Ma C Abstract Tripartite motif containing 28 (TRIM28) is a universal corepressor for Kruppel‑associated box zinc finger proteins. In our previous study, it was shown that expression of TRIM28 is upregulated in non‑small cell lung cancer (NSCLC) cell lines and tissues. Here, we demonstrated that the stable silencing of TRIM28 expression by a specific siRNA lentivirus vector increased the sensitivity of NSCLC cells to chemotherapeutic agent etoposide. Combination of TRIM28 siRNA and etoposide significantly inhibited the growth and proliferatio...
Source: Oncology Reports - May 13, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of PARP6 or survivin promotes cell apoptosis and inhibits cell invasion of colorectal adenocarcinoma cells.
Authors: Wang H, Li S, Luo X, Song Z, Long X, Zhu X Abstract Colorectal adenocarcinoma is the third most common cancer worldwide. PARP6, a novel member of the poly(ADP-ribose) polymerases (PARPs) and survivin, a member of the family of inhibitor of apoptosis (IAP) proteins are associated with a poor prognosis in various types of cancers. However, limited evidence exists regarding the interaction between PARP6 and survivin in colorectal adenocarcinoma. In the present study, we used the paired samples of 20 patients with colorectal adenocarcinoma to detect the expression of PARP6 and survivin in both tumor and adjac...
Source: Oncology Reports - March 6, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Corrigendum BMI ‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor
Oncol Rep. 2022 Aug;48(2):141. doi: 10.3892/or.2022.8352. Epub 2022 Jun 22.ABSTRACTFollowing the publication of the above paper, an interested reader drew to the authors' attention that, in Fig. 5 on p. 1637, the data panel selected to represent the 'Ishikawa/+BMI‑1 siRNA/Invasion' experiment in Fig. 5A appeared to overlap with the data shown for the 'JEC/+BMI‑1 siRNA/Migration' panel in Fig. 5C, such that they were potentially derived from the same original source. The authors have re‑examined their original data, and realize that the data panel selected for the 'Ishikawa/+BMI‑1 siRNA/Invasion' experiment in Fig. ...
Source: Oncology Reports - June 22, 2022 Category: Cancer & Oncology Authors: Jing Yu Ling Chen Zhenhua Bao Ying Liu Guohong Liu Fengling Li Lianqin Li Source Type: research

Dickkopf‑3 (Dkk3) induces apoptosis in cisplatin‑resistant lung adenocarcinoma cells via the Wnt/β‑catenin pathway.
In conclusion, the re‑activation of Dkk3 enhances the chemosensitivity to cisplatin in cisplatin‑resistant lung adenocarcinoma cell lines, which requires additional studies to realize this potential in clinical use. PMID: 25573172 [PubMed - as supplied by publisher]
Source: Oncology Reports - January 16, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

NFATc1 regulates cell proliferation, migration, and invasion of ovarian cancer SKOV3 cells in vitro and in vivo.
Authors: Li L, Duan Z, Yu J, Dang HX Abstract NFATc1 (nuclear factor of activated T‑cells c1) is associated with malignancy in several cancer models. However, the expression and function of NFATc1 in ovarian cancer remain elusive. In the present study, we investigated the role of NFATc1 in human epithelial ovarian cancer (EOC) using human ovarian adenocarcinoma SKOV3 cells and patient characteristics. NFATc1 expression was silenced by siRNA in the SKOV3 ovarian cancer cell line and in human ovarian cancer nude mouse xenografts. Real‑time PCR, western blotting, immunohistochemical staining, MTT, flow cytometry, ...
Source: Oncology Reports - July 1, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of c ‑Myc activates Fas-mediated apoptosis and sensitizes A549 cells to radiation.
In this study, we established radiation-resistant A549 cell model (A549/R), and investigated the roles of c‑Myc and Fas in radiation-induced cytotoxicity of A549 cells. Apoptosis detection showed that there were fewer apoptotic cells in A549/R cells treated with radiation than in A549 cells. Western blotting results demonstrated the inverse expression pattern of c‑Myc and Fas in A549 and A549/R cells. Suppression of c‑Myc expression by small interfering RNA (siRNA) displayed enhancement of Fas-mediated apoptosis in A549/R cells, accompanying a significant decrease of Bid, Bcl‑2, pro‑caspase‑8, -9 and -3 and inc...
Source: Oncology Reports - August 31, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Low expression of PRKCDBP promoted cisplatin resistance in lung adenocarcinoma by DNMT1 and TNF ‑α.
In conclusion, low expression of PRKCDBP promoted cisplatin resistance in LAD by DNMT1 and TNF‑α. PMID: 32945503 [PubMed - as supplied by publisher]
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Paxillin is positively correlated with the clinicopathological factors of colorectal cancer, and knockdown of Paxillin improves sensitivity to cetuximab in colorectal cancer cells.
Authors: Du C, Wang X, Zhang J, Liu X, Zhu J, Liu Y Abstract Paxillin (PXN) encodes a 68-kDa focal adhesion-associated protein and plays an important role in signal transduction, regulation of cell morphology, migration, proliferation and apoptosis. The aim of the present study was to evaluate the relationship between PXN and clinicopathological factors in colorectal cancer, the role of PXN in cetuximab resistance, and whether knockdown of PXN expression could improve the sensitivity to cetuximab in colorectal cancer cells. In the present study, immunohistochemical staining in 148 colorectal carcinoma and 126 nor...
Source: Oncology Reports - November 7, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of importin-9 protects MCF-7 cells against apoptosis induced by the combination of garlic-derived alliin and paclitaxel.
Authors: Izdebska M, Grzanka D, Gagat M, Hałas-Wiśniewska M, Grzanka A Abstract Numerous studies on the biological mechanism of breast cancer have identified a number of potential therapeutic molecular targets. In this context, one type of potential candidates appears to be agents that target the actin cytoskeleton of cancer cells or regulate actin cytoskeleton dynamics. The aim of the present study was to study the impact of altered actin transport between the cytoplasm and nucleus by the downregulation of importin-9 (IPO9) in breast adenocarcinoma MCF-7 cells exposed to an apoptosis-inducing combination of garl...
Source: Oncology Reports - March 6, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TGF- β1-induced cell migration in pancreatic carcinoma cells is RAC1 and NOX4-dependent and requires RAC1 and NOX4-dependent activation of p38 MAPK.
TGF-β1-induced cell migration in pancreatic carcinoma cells is RAC1 and NOX4-dependent and requires RAC1 and NOX4-dependent activation of p38 MAPK. Oncol Rep. 2017 Oct 12;: Authors: Witte D, Bartscht T, Kaufmann R, Pries R, Settmacher U, Lehnert H, Ungefroren H Abstract Transforming growth factor (TGF)-β promotes epithelial-mesenchymal transition and cell invasion of cancer cells in part through the small GTPase RAC1. Since RAC1 can signal through reactive oxygen species (ROS), we probed the role of the ROS-producing NADPH oxidase (NOX) and p38 mitogen-activated protein kinase (MAPK) in mediating TG...
Source: Oncology Reports - October 20, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

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