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Ginkgo diterpene lactones inhibit cerebral ischemia/reperfusion induced inflammatory response in astrocytes via TLR4/NF-κB pathway in rats
Conclusions:In summary, GDL attenuate cerebral ischemic injury, inhibits platelet aggregation and astrocytes activation. The anti-inflammatory activity might be associated with the downregulation of TLR4/NF-κB signal pathway. Our present findings provide an innovative insight into the novel treatment of GDL in ischemic stroke therapy.Graphical abstract
Source: Journal of Ethnopharmacology - October 31, 2019 Category: Drugs & Pharmacology Source Type: research

Achyranthes aspera Linn. Alleviates cerebral ischemia-reperfusion-induced neurocognitive, biochemical, morphological and histological alterations in Wistar rats
ConclusionsThese findings suggest that the MeAA possesses potent cerebroprotective action through its antioxidant and anti-inflammatory mechanisms.Graphical abstract
Source: Journal of Ethnopharmacology - September 15, 2018 Category: Drugs & Pharmacology Source Type: research